Most of the anabolic steroid not only dock to the androgen receptor, but also to the receptors for estradiol and progesterone. Knowledge about that is also relevant to steroids users, because the progestogenic and estrogenic effect of steroids tells us something about their possible side effects. In 2009 some Dutch researchers published a survey which might benefit health conscious steroids users.
The more you know about anabolic steroids, they more complex they seem to be. If you start to study the chemistry of anabolic steroids you start to understand how various modifications are meant to prevent the conversion of steroids into estradiol-like and DHT-like hormones, while at the same time allowing for an increased anabolic effect. But if you understand that, you'll discover that it all works just a bit more complicated.
Take nandrolone. Nandrolone differs from testosterone because nandrolone lacks a 19-methyl group. Thereby the aromatase enzyme converts nandrolone harder than testosterone into estradiol. At the same time that the omission of 19-methyl group ensures that the anabolic effect of nandrolone is stronger than that of testosterone.
The absence of the 19-methyl group allows nandrolone to attach to the androgen receptor about two times better than testosterone. Because, by the omission of the 19-methyl group of nandrolone it can no longer convert in the androgen testosterone metabolite DHT, at the same time nandrolone has less androgenic side effects than testosterone. Testosterone converts easily into DHT, DHT is hardly anabolic but strongly androgenic, and DHT can attach to the androgen receptor 3 times better than testosterone.
In the eighties, however, users found that nandrolone still has side effects caused by female hormones. At somewhat higher doses, men can develop breasts (gyno) from nandrolone,. This is probably because nandrolone can attach itself to the estradiol receptor. By the absence of the 19-methyl group Nandrolone is also a bit of an estrogen.
It also became clear that nandrolone in somewhat higher doses suppressed the body's endogenous production of testosterone to a greater extent than synthetic testosterone. That is because nandrolone by the absence of the 19-methyl group is also suitable for the progesterone receptor. The combined androgen-estrogen-progestational effect of nandrolone, causes the steroid in the hypothalamus to press to all the buttons that reduce the body's own testosterone production. By the same mechanism nandrolone users can become temporarily impotent, and nandrolone was in animal studies more harmful for the heart and blood vessels than testosterone.
The story becomes even more complex. In the 21st century it became clear that steroid receptors in cells - and hence in muscle cells – worked together. The signal that the androgen receptor, after forming a complex with an anabolic steroid, that tells the muscle to become bigger, becomes stronger if the cell at the same time receives stimuli via the estradiol and progesterone receptor. That idea was the starting point of the thesis of Barry Blankvoort. [Development of an endogenous androgen receptor-mediated luciferase expression assay for interactive androgenic action, Wageningen 2003] If you've read it you look differently to cycles and stacks, and take all those messages about endocrine disruptors in our food a lot more serious. Ergo: the same mechanism by which nandrolone exerts so many side effects, also makes nandrolone such effective muscle builder.
Another new supplement hyped by the supplement industry. Everybody that saw the documentary “Bigger - Stronger – Faster” knows that this industry sells dreams. But most guys fall for the nice adds, the science backed “evidence” and the pictures of athletes pumped up by anabolic steroids (…and a lot of other “illegal means” ) that REALLY work wonders on your appearance, telling you this supplement is responsible for their gains.
Years ago when the counterfeit and fake steroids started to ruin the industry. We made the buyers aware of that fact and we started to teach the members via the messageboards to check the available information on the product and the boxes and leaflets.
Most of the anabolic steroid not only dock to the androgen receptor, but also to the receptors for estradiol and progesterone. Knowledge about that is also relevant to steroids users, because the progestogenic and estrogenic effect of steroids tells us something about their possible side effects. In 2009 some Dutch researchers published a survey which might benefit health conscious steroids users.
When we wrote the Underground Book Thailand had closed his borders for Steroids and Male enhancement pills, mostly counterfeited Viagra. Pfizer makes millions of profit, producing a sildenafil containing tablet costs only cents and they sold it for a hundred fold. Thailand also sold cheap generic tablets and many people where able to buy outside their regional healthsystem. We all know how strong the pharmaceutical lobby is. The uSA protects his taxpayers and the pressure on Thailand became so high that it gave in.
When testosterone levels are normal, and a man is experiencing signs of andropause, the hormonal culprit is usually estrogen (and chemicals that mimic the actions of estrogen), the female hormone. Both men and women have specific amounts of estrogen in their bodies. Young men may have a ratio of testosterone to estrogen of 50:1. The ratio drops to 20:1 or even as low as 8:1 with normal aging.
I get many questions about infections or even abcesses. Mostly people blame the Underground Lab, posting the product was not sterile etc. In reality its better first to check on Google if you can find more cases of infection. Because a batch is in most cases much bigger than 1 vial. Most UG labs manufactur a kilo of API (raw powder). A batch of 250 mg/ml wil therefore be around 400 pcs.
This is supposedly one of the first steroids in circulation in bodybuilding circles. Its what Arthur Jones had Bill Pearl on in 1956, and it gave him a gain of 30 pounds to win the Universe that year. Not coincidentally 1956 was the release of Nilevar by Searle in the US. The same company that would later bring us Anavar (oxandrolone) which was a lot milder on the system and notably less toxic. Nilevar is rarely used these days.