The research towards the myostatin inhibitor ACE-031 was terminated - but it does work

The pharma companies Acceleron Pharma and Shire have put the myostatin inhibiter ACE-031 on ice. That have indicated. [ May 2, 2013] And that's pretty weird. Them in a joint press release a few days ago

A few weeks earlier, Muscle & Nerve published a study showing that ACE-031 is a compound which a chemical bodybuilder would gladly add to his toolbox.

The injectable ACE-031  is a synthetic activin receptor type IIB. Muscle cells have that receptor too. It is intended for proteins as myostatin, GDF11 and activin A and B. If myostatin docks itself to the activin receptor type IIB, then the growth of muscle fibers reduces. Under the 'right' circumstances myostatin even breaks down muscle.

If you inject ACE-031, then that does not happen. The synthetical activin receptor type IIB captures the muscle inhibitory proteins away, and disable them.


Thymosin beta 4 ( akaTB500)

Bodybuilders once started to use Boldenone and Trenbolone which was meant for cattle to beef up. Als many vitamin preparations where used from France. Now a new and exiting veterinary peptide emerged. Now available  with an acetate estrification for use in humans.  It seems to help after hairloss too. It was first used in horses but now the first bodybuilders start to use it.  Now I hear more and more that top athletes try this new peptide.

TB-500 or Thymosin Beta 4, as it is called, is a exploration peptide that is tested primarily for its abilities to increase strength, endurance and restoration in subjects. It is often used in horses in the course of clinical trials and is sold for study purposes only. It is known to have many of the same effects of growth hormone in animals equating to results in humans that would be related to an increase in testosterone Inspite of. It has been shown to inhibit tumor growth making TB-500 a amazing product for research studies and with further testing, something that may become widely accepted in the minds of many.

Methasterone is an oral anabolic steroid that was never marketed through legitimate channels for medicinal purposes. It was brought to market, instead, in a clandestine fashion as a "designer steroid.”

The synthesis of methasterone is first mentioned in the literature in 1956 in connection with research conducted by Syntex Corporation in order to discover a compound with anti-tumor properties.[1] This initial mention is elaborated upon in a 1959 research journal article, where its method of synthesis is discussed in greater detail, its tumor inhibiting properties are verified, and it is noted as being a “potent orally active anabolic agent exhibiting only weak androgenic activity.”[2] The results of subsequent assays to determine methasterone’s anabolic and androgenic activity were published in Vida’s Androgens and Anabolic Agents, a dated but still standard reference, where it was noted that methasterone possessed the oral bioavailability of methyl-testosterone while being 400% as anabolic and 20% as androgenic, yielding a Q-ratio (also known as an anabolic to androgenic ratio) of 20, which is considered very high.[3]


Testosterone Suspension is one of the most explored names on the Internet. The reason – this testosterone mixture is the best efficiency improving drug for professional sportsmen preparing themselves for a sport meet. Moreover, the anabolic steriod is an affordable, efficient, and safe efficiency increaser that can be easily purchased online, with or without a healthcare prescription.

Considered to be the first anabolic androgenic steroid developed and used for building solid muscle tissue, Testosterone Suspension has been one of the most successful given for the last many decades. Sportsmen, especially muscle builders and sportsmen trust this testosterone compound for its unrivaled efficiency.

A woman asked our help in the forum:


"I need your help....has anyone ever experienced the following reaction or know anyone that has??
Three months ago I pinned HGH frag #177-191 all around my bellybutton and within a week, the fat/tissue was swollen and almost hard to the touch. I never experienced a fever, redness, burning or itching so the doc said "no infection". Recently someone suggested that I try a therapeutic ultrasound machine along with the graston technique. I am seeing a chiropractor and he is treating me with these techniques every other hopes to break up the tissue so my body will naturally absorb it.

I have seen the following doctors - general surgeon, doctor, plastic surgeon, chiropractor and dermatologist so far without any true answers. I have tried Keflex, and am about to start my 2nd round of Prednisone. The Prednisone has softned the hard tissue but the dougnut shape is still there. If anyone knows what this is and how it can be treated please let me know. I really am desperate to get this issue fixed ASAP w/out plastic surgery."

This thread covered many aspects of  topical treatment thats why I thought I could help you guys and gals by posting it on the blog where it stays better available then in in the discussionforum.


What is the difference between bacteriostatic water and sterile water?

 Bacteriostatic Water for Injection, USP is a sterile, nonpyrogenic preparation of water for injection containing 0.9% (9 mg/mL) of benzyl alcohol added as a bacteriostatic preservative, ie. Bacteriostatic water is sterile water which contains a bacteriostatic preservative

 Sterile Water for Injection, USP is a sterile, nonpyrogenic preparation of water for injection, which contains no bacteriostat, antimicrobial agent or added buffer. (Nonpyrogenic - will not cause fever)

 Sterile water and Bacteriostatic Water are made in special laboratories and are often used as a diluent for injections.

Bacteriostatic Water with isotonic NaCl solution for Injection  (the 1ml solvent that comes with HCG amps fromOrganon Pregnyl)

Oral – liquid and injectable d-bol ( Dianabol, methandrostenolone, methandiënone).

Everyone has a favorite, a favorite moviestar, a favorite song etc, we bodybuilders also have favorite exercises, musclegroups. But we also have favorite steroids. Me, I like Dianabol (methandrostenolone/methandiënenone). Its an old saying:  “if you can’t grow on d-bol and test, you can’t grow on anaything”. Even if Arnold swore on the combo Deca/D-bol, I prefer the combo Test/Dbol. Everyone reacts different on the diverse cycles and means, its induvidual, just like taste.

I posted the cited article on Methandrostenolone here:  // .

There I also posted this exerpt from the first patent application for 1-dehydrotestosterones which resulted in studies with these new compounds. The scientists from CIBA described a way to manufacture 1 ml ampoules of oil based methandrostenolone for injections. It is pretty obvious that the CIBA scientists studied the results of this new injectable.

Lets take a side step to clarify what I wanna tell you.

Boldenone was  created while chemists where attempting to create a long acting injectable Dianabol (Methandrostenolone). A simple way to think of Boldenone, chemically at least, is that it is  Dianabol without the 17-alpha-methyl group (that´s what makes Dianabol able to be ingested orally without being destroyed by the first pass trough the liver).  Its shows how even the smallest modification of the chemical structure can completely change a steroids properties.  Boldenone is a 1-dehydro derivative of testosterone. Boldenone with an undecyclenate ester has been sold as a veterinary preparation under the brand name Equipoise. Everybody that knows about these compounds knows that Bodenone undecylenate is completely different from Dianabol, which on its turn is completely different from injectable Dianabol.

 HELIOS injectable liposuction.

Helios was originally developed by an idea from the legendary body-building guru Dan Duchaine.   Hard Core Labs (HCL) is selling this extremely potent solution on the bodybuilding market. The ingredients (Clenbuterol and Yohimbine HCL) are forbidden in almost every country, as well as administration via injection. This is only allowed by a doctor or medical trained nurse. But this form of administration is also the best way for spot reduction.

The art of spot reduction.

When you begin a diet, you may notice that you lose fat very unevenly on your body. The areas you don't wish to concentrate your fat loss seem to be most responsive to the restriction of calories. On the other hand, the areas you desire to shed fat seem to be unaffected by the diet. In women, the breasts may be shrinking, while the lower body remains as fat as it was. In men, even if the waist is getting smaller, the abs are not getting any more visible. Why put your body through a tough and often unhealthy diet if unwanted inches of fat remain? What we want is a specifically targeted fat loss, but we are told that spot reduction is impossible! Is this true?