Somatrem is a synthetically manufactured form of human growth hormone. It is actually a variant of endogenous human growth hormone protein, containing the same sequence of 191 amino acids, but with the addition of an extra amino acid, methionine. For this reason somatrem is commonly described as methionyl human growth hormone. As an human growth hormone medication, somatrem supports the growth of bone, skeletal muscle, connective tissues, and internal organs. It also plays a role in protein, carbohydrate, lipid, and mineral metabolism. In a medical setting, somatrem is used to treat childen with growth failure caused by endogenous growth hormone deficiency. When administered as a long term treatment before linear growth is stopped due to closed growth plates, the drug may impart a significant positive effect on linear growth. Somatrem is considered to be therapeutically equivalent to growth hormone or pituitary origin. As an human growth hormone drug, somatrem is valued by bodybuilders and athletes for its ability to promote fat loss and muscle and connective tissue growth. Somatrem was approved for sale by the FDA in the United States in 1985. It was the first synthetic growth hormone medication available worldwide, produced via a manufacturing process called Inclusion Body Technology. The technology involves inserting the DNA encoding for the human growth hormone protein into Escherichia coli bacteria, which assemble and synthesize the pure protein. Prior to the advent of synthetic growth hormone, HGH was made into a medication only by extracting the natural protein from human cadavers. Biological or cadaver HGH, as it was called, was banned in the U.S in 1985 due to the high prevalence of a rare neurological disease known as CJD in patients. Somatrem was approved for sale that same year, giving the company that produced it a short monopoly on the growth hormone market. Somatrem is most commonly supplied in multi dosed vials containing a while lyophilized powder that requires reconstitution with sterile or bacteriostatic water before use.