Peptides

At the start of the year 2014 this news dominated the broadcasting about the Wintergames in Sotsji Russia.

Full Size MGF – New Doping Substance from Russia

I posted about MGF earlier here: //www.juicedmuscle.com/jmblog/content/mgf-mechano-growth-factor

The most credible German TV station (ARD, 02.02.2014) revealed with an undercover journalist that some well-known Russian biology professor/scientist (they do not mention his name) is selling a new doping substance called "Full Size MGF".

The undercover journalists got 1 milligram of the drug “Full Size MGF”,  to test it.

For 100,000 euro the rogue scientist , working at the Russian Academy of Sciences in Moscow , could provide an amount (100 mg ) that athletes could  use for the Winter Olympics in Sochi . The ideal time to take the product would be 2 or 3 days before a contest

They gave the "Full Size MGF" to the IOC/WADA Anti-Doping Laboratory in Cologne. According to the IOC/WADA laboratory, "Full Size MGF" acts like IGF-1, but much stronger and they also stated that they have never heard of it before and that they of course don't have any test for it. . David Howman,

 Director General of the World Anti- Doping Agency , WADA , was therefore shocked when he saw the WDR report . "It would be naive to believe that they are all athletes who will participate in Sochi are pure. " The IOC doping testing plant in 2453 in Sochi , the highest ever number of doping tests at the Games .
The most interesting part is, that this Russian biology professor/scientist is apparently selling MGF since 2010! That means the IOC/WADA might be 3-4 years late!

Is this new??

Of course NOT, in  April 2013 this headline appeared on the news and the web:

Doping probe rocks Australian sport !

I wrote a lot about the Chinese Growth Hormone which is very popular among bodybuilders, athletes, anti-aging adepts etc.

Underneath this article you can find the links to the articles where I explain, how the different Chinese companies are to be recognized. Jintropin was extremely popular some time ago and the boxes on the left where being sold in mass. When a product brings such high sales and profits, there are always people that counterfeit this product or try to sell fakes. The box on the left is a counterfeit (marked with an F), the box on the right is a real Jintropin box..  A counterfeit is a product that looks like the real product and also contains the same active ingredient. In this case somatropin or rhGrowth Hormone. A fake is mostly a product that looks like the original product but has no active ingredient or another active ingredient. The counterfeited products are mostly under dosed as you will notice later in this article.

 kfsdjhgdshjhhhaawwweeaaa aaaa Since the times of the first, ancient Olympics, since the dawn of sports people have been cheating. That was then and that is now. Anti-doping organizations and sports associations are constantly chasing dopers who resort to more radical means every time. The lengths to which these “athletes” go to get an advantage is sometimes shocking. They are literally putting their lives in danger by experimenting with non-clinically tested drugs.

This blog post is meant to give an insight in the newest doping products that are out there on the market and to show how hard it is to actually detect these. And how scientific progress is often misused by cheaters. The sources I used are all scientific and can be send upon request.

In 2008, Cell published an article which was looked on with interest by the world of sports. Professor Ron Evans of La Jolla, California was doing research to find a cure for the increasing epidemic of obesity and diabetes. He found a substance that would trick the cells in thinking they exercised a lot while in fact they had been mostly idle. The mice ran faste, had better endurance and burnt fat.

When the mice were actually following a training regime the results almost doubled. The media dubbed it the “coach-potato drug”, the miracle cure to obesity and diabetes for people who were unable to exercise.

GW 1516 is often used in a "synergistic" combo with Aicar. Is it worth anything for bodybuilders. What do the analyses of black market analyses say. These chemicals are yet very hot and many "research chemicals" rave about it on forums (often as the sponsor). But is a fat or does it contribute to our chemical toolbox?

GW-1516 (also known as GW-501,516,GW501516 or GSK-516) is a PPAR 948; modulator compound being investigated for drug use by GlaxoSmithKline.[1][2] It activates the same pathways activated through exercise, including PPAR 948; and AMP-activated protein kinase. It is being investigated as a potential treatment for obesity, diabetes, dyslipidemia and cardiovascular disease. [3] [4] GW-501516 has a synergistic effect when combined with AICAR: the combination has been shown to significantly increase exercise endurance in animal studies more than either compound alone. [5][6]

GW-50156 regulates fat burning through a number of widespread mechanisms [7]; it increases glucose uptake in skeletal muscle tissue and increases muscle gene expression, especially genes involved in preferential lipid utilization.,[8][9] [10] This shift changes the body's metabolism to favor burning fat for energy instead of carbohydrates or muscle protein, potentially allowing clinical application for obese patients to lose fat effectively without experiencing muscle catabolism or the effects and satiety issues associated with low blood sugar. [11] GW-501516 also increases muscle mass, which improved glucose tolerance and reduced fat mass accumulation even in mice fed a very high fat diet, suggesting that GW-501516 may have a protective effect against obesity [12]

Peptide Guide :

1 - You are on this site because you have heard of and want to become more familiar with Growth Hormone Releasing Peptide (GHRP) and/or Growth Hormone Releasing Hormone (GHRH). These 2 materials administered can give you an increased quality of life in ways of anti-aging, muscular hypertrophy, fat loss, injury repair, higher bone density, and better sleep.

2 - GHRP can be used on its own to increase our natural Growth Hormone (GH) pulse release from the Pituitary Gland in the brain. GHRP dosed in conjunction with GHRH will amplify our growth hormone release significantly to gain maximal benefit.

3 - There are various types of GHRH's. The only GHRH to consider is tetra-substituted CJC-1295 / CJC-1295(without DAC) / modGRF(1-29). They are all the same thing but with a different name. They come in vials ranging in material weights measured in milligrams (mg) consisting of a solid freeze-dried (lyophilized) substance.

4 - There are various types of GHRP's. GHRP-6, GHRP-2, Hexarelin, and Imaporelin. The differences between them are potency and side effects. GHRP-6 is very potent and makes you quite hungry. GHRP-2 is potent and can slightly affect your sleep somewhat. Hexarelin is very potent but you can desensitize from higher dosages. Imaporelin is potent with the minimalist side effects of all 4 GHRP's.

5 - Peptides are dosed via a regular 1mL needle syringe typical to what a diabetic would use. It is administered Subcutaneously (SubQ) (just under the skin into the fat tissue), most usually around the abdomen region.

6 - The required amount (saturation dose) is 1mcg (microgram) per Kg (Kilogram) of bodyweight. The typical usage and for ease of measuring is 100mcg of modGRF(1-29) and/or 100mcg of your choice of GHRP. Lower dosages will simply result in less GH release due to a slightly weaker GH pulse and reduce any side effects you may have. A higher dose will have minimal benefit and is more a waste of money than anything else. But, in saying that, the more frequently dosed in any given day would result in more frequent pulses.

Thymosin beta 4 ( akaTB500)

Bodybuilders once started to use Boldenone and Trenbolone which was meant for cattle to beef up. Als many vitamin preparations where used from France. Now a new and exiting veterinary peptide emerged. Now available  with an acetate estrification for use in humans.  It seems to help after hairloss too. It was first used in horses but now the first bodybuilders start to use it.  Now I hear more and more that top athletes try this new peptide.

TB-500 or Thymosin Beta 4, as it is called, is a exploration peptide that is tested primarily for its abilities to increase strength, endurance and restoration in subjects. It is often used in horses in the course of clinical trials and is sold for study purposes only. It is known to have many of the same effects of growth hormone in animals equating to results in humans that would be related to an increase in testosterone Inspite of. It has been shown to inhibit tumor growth making TB-500 a amazing product for research studies and with further testing, something that may become widely accepted in the minds of many.

MGF (Mechano Growth Factor).

Just after the second world war a hopeful world produced a large new generation. Most of them did well. They have worked their whole life and are willing to pay for pharmaceutical aids that will prolong and ease their “golden years”. They want to grow old, but they want to grow old gracefully, maintaining their youthful skills. They don’t want to spent their last years in a wheelchair or in a nursing bed with a bedpan. They want to remain mobile and have a healthy sexlife. The success of Phizers Viagra proves that. 

Authorities all over the world are facing huge healthcare costs due to an aging babyboom. The steady loss of bone mass (osteoporosis) and of lean muscle mass (sarcopenia) that accompanies aging puts an increasing strain on our health care systems. It afflicts millions of aging people all over the world. Age-related loss of muscle mass, strength and frailty caused by declining levels of  essential hormones in the body such as sex hormones and growth hormone stops them from carrying out everyday tasks and increases the riskof falling and breaking bones that are brittle because of osteoporosis. This is not only a major socio-economic as well as a major medical and financial problem, it is also important to improve the overall well-being of all these elderly. All this led to increased funds and need for scientific research towards prevention of age related diseases.  We already knew that the  exogenous administration of rhGH and sex-hormones such as Testosterone (HRT) could improve overall well-being in elderly.

 

The average person thinks of the damage of aging as an inevitable process of wear and tear.   However, if wear and tear were the primary cause of aging in humans, a 60 year-old should have only twice the signs of aging as a 30 year-old.

Why do most 30-year-olds show few effects of aging, while the effects of aging are so obvious in a 60 year-old person?   If wear and tear were the major cause of aging, a 90-year-old person would only have 3 times as much aging damage as a 30-year-old.

At the age of 30, people have spent most of their lives with fairly high levels of human growth hormone (HGH).   HGH is responsible for growth during childhood -- and for the repair and regeneration of human tissue throughout our lives.   By the time we reach the age of 30, our HGH levels are only about 20 percent of their peak levels during childhood, and after the age of 30, they continue to decline at about 12 to 15 percent per decade, and often much more.   By the time most of us are 30 years old, our bodies no longer produce enough HGH to repair all of the damage that is occurring in our bodies.   As our HGH levels continue to decline, the damage that we call aging continues to accelerate.

The decline in HGH is not the only cause of the manifestations of aging.   Even if our HGH levels remained at the level of a 25 year-old, we would continue to experience the effects of aging, but those effects would be greatly reduced until we reached a very advanced age.   HGH does not affect the root cause of aging, as measured by maximum lifespan, but it can certainly affect many of the manifestations of aging.

By increasing the levels of HGH in our bodies, we can slow, or even reverse, many of the manifestations of aging.   It must be done carefully, though, and under medical supervision.   Ideally, this HGH replacement should begin at about the age of 30 years, but HGH replacement can be beneficial at any age above 30.   In fact, for older people, HGH therapy can reverse the manifestations of aging by 5 to 15 years or more.   There is no other single therapy currently available that can have the impact on the aging body that HGH can have.

A USERS GUIDE:

Growth Hormone is a single chain polypeptide hormone produced by the pituitary gland. It’s a combination of 191 amino acids set in an exact order to make its formation. Years ago it was made from the corpus of dead people. Of course as of recently; it is developed in a lab. GH is involved in MANY different hormonal processes that include reducing insulin sensitivity, fat burning, reproduction, regulating basal body temperature, hair and nail growth, protecting the immune system, bone growth/formation and the main reason bodybuilders use it for which is muscle growth. The most common effect reported from using GH is an increase in a sense of overall well being. People seem to feel a lot younger when taking it on a daily basis. HGH secretes most during high intensity exercise, sleep. During the first few hours of sleep, Growth Hormone Releasing Hormone peaks while Somastatin levels drop. Growth Hormone Releasing Hormone is responsible for releasing HGH and IGF-1 levels. When GHRH and IGF-1 levels are too high, the body creates the negative feedback loop which stops the release of both hormones. High levels of Somastatin cause a dramatic increase in IGF-1 levels which stops the release of HGH. Somastatin is usually obtained from low blood glucose levels. Ghrelin binds to the receptors on somatotrophs and dramatically stimulates the secretion of Human Growth Hormone. The Ghrelin signal is combines with the growth hormone releasing hormone and somatostatin to control the timing and level of growth hormone secretion. Human Growth hormone also stimulates triglyceride hydrolysis in adipose tissue, which usually produces notable fat loss during usage of HGH. HGH also increases glucose output in the liver, and stimulates insulin resistance by blocking the activity of this hormone in those specific targeted cells. HGH increases absorption of protein and other macro/micro nutrients, it also speeds up the metabolism fast enough to start burning fat. HGH builds muscle and burns fat at the same time; it will GREATLY enhance the results you are seeking, and can be used on and off cycle.

A woman asked our help in the forum:

//juicedmuscle.com/showthread.php?4768-Bad-Peptide-Reaction-on-Stomach

"I need your help....has anyone ever experienced the following reaction or know anyone that has??
Three months ago I pinned HGH frag #177-191 all around my bellybutton and within a week, the fat/tissue was swollen and almost hard to the touch. I never experienced a fever, redness, burning or itching so the doc said "no infection". Recently someone suggested that I try a therapeutic ultrasound machine along with the graston technique. I am seeing a chiropractor and he is treating me with these techniques every other day...in hopes to break up the tissue so my body will naturally absorb it.

I have seen the following doctors - general surgeon, doctor, plastic surgeon, chiropractor and dermatologist so far without any true answers. I have tried Keflex, and am about to start my 2nd round of Prednisone. The Prednisone has softned the hard tissue but the dougnut shape is still there. If anyone knows what this is and how it can be treated please let me know. I really am desperate to get this issue fixed ASAP w/out plastic surgery."

This thread covered many aspects of  topical treatment thats why I thought I could help you guys and gals by posting it on the blog where it stays better available then in in the discussionforum.