Oral – liquid and injectable d-bol ( Dianabol, methandrostenolone, methandiënone).

Oral – liquid and injectable d-bol ( Dianabol, methandrostenolone, methandiënone).

Everyone has a favorite, a favorite moviestar, a favorite song etc, we bodybuilders also have favorite exercises, musclegroups. But we also have favorite steroids. Me, I like Dianabol (methandrostenolone/methandiënenone). Its an old saying:  “if you can’t grow on d-bol and test, you can’t grow on anaything”. Even if Arnold swore on the combo Deca/D-bol, I prefer the combo Test/Dbol. Everyone reacts different on the diverse cycles and means, its induvidual, just like taste.

I posted the cited article on Methandrostenolone here:  //juicedmuscle.com/jmblog/content/dianabolr-history-use-and-dosages .

There I also posted this exerpt from the first patent application for 1-dehydrotestosterones which resulted in studies with these new compounds. The scientists from CIBA described a way to manufacture 1 ml ampoules of oil based methandrostenolone for injections. It is pretty obvious that the CIBA scientists studied the results of this new injectable.

Lets take a side step to clarify what I wanna tell you.

Boldenone was  created while chemists where attempting to create a long acting injectable Dianabol (Methandrostenolone). A simple way to think of Boldenone, chemically at least, is that it is  Dianabol without the 17-alpha-methyl group (that´s what makes Dianabol able to be ingested orally without being destroyed by the first pass trough the liver).  Its shows how even the smallest modification of the chemical structure can completely change a steroids properties.  Boldenone is a 1-dehydro derivative of testosterone. Boldenone with an undecyclenate ester has been sold as a veterinary preparation under the brand name Equipoise. Everybody that knows about these compounds knows that Bodenone undecylenate is completely different from Dianabol, which on its turn is completely different from injectable Dianabol.

Surfing the net I found many threads on oral and injectable 17alpha mythylated steroids. I was struck by some lack of knowledge. Members asking for help and information. Others providing the right info are being put down as ingnorant, rookies or just plain stupid. It seems that the biggest mouth is always right. Therefore some information on this subject

Dan Duchaine in his first Underground Steroid book raved about Reforvit-B and later convinced “International Pharmaceuticals” to launch their products on the US market. The first product from IP that came on the US black market was ……. IP injectable Dianabol.

Reforvit-B  25 mg/ml, 10 ml / and 50 ml vials (made by Loeffler in Mexico) are a veterinary compound used to treat animals. Methandrostenolone is a steroid used as veterinary medicine on stockbreeding to promote animal growth and for overall animal health. It”s methandrostenolone and vitamin B, hence the name. It contains:

Methandrostenalona.....................25.0 mg

Riboflavina 5-fosfato...................... 1.0 mg

Piridoxina clorhidrato..................... 2.5 mg

Nicotinamida.................................10.0 mg

Vitamina B-12...............................25.0 mcg

(Nicotinamide is also known as vitamin b-3. It is  a slow release version of Niacin.)

Reforvit-B is not solved in oil but in Propylene glycol, with some procaine added to lessen the pain. Because it was solved in propylene glycol Reforvit-B was very painful to inject, to avoid the pain people tried to swallow it, but it tasted terrible. On the boards members informed each other to inject the Reforvit into vitamin capsules from the health food store with a needle. Of course there where also Reforvit tablets available from Loeffler

Dan Duchaine was not the only one enthusiastic about injectable Dianabol, Dave Palumbo stated in an article:

"Most of you who regularly read my column already know: I hate oral steroids. They're liver toxic, they kill your appetite and they dont last very long in the body. Liquid Dianabol, however, is a very different beast. When Dianabol is injected intramuscularly, the apetite-supressing effects disappear, the liver toxicity drops and the muscle-building effects are maximized. Simply explained, when you consume the correct amount of food and your liver efficiently processes that food, you create the ideal anabolic environment. Stick with dosages of 25-50 mg EOD."

More veterinary compounds

In the early days bodybuilders started to stack their human grade testosterones with veterinary steroids. This where the Reforvit-B (methandrostenolone) and Equipoise (Boldenone) as discribed here, and Winstrol-V (stanozolol) and Trenbolone made from animal pellets. There where many drawbacks such as the low dose, the lack of sterility and the pain. The Winstrol was very thick compared to the ultra fine powder from today. The Methandrostenolone in Reforvit was solved in Propylene Glycol which was very painful to inject there fore the combination also contained some procaine. The Equipoise was very low dosed and required massive injection. The Winstrol-V had to be injected with a thick needle and was therefore mostly used orally, which influenced the bioavailability. The Trenbolone was extracted from the pellets with help of acetone and after that had to be filtered, it was mostly not pure and sterile, and that’s an understatement. Who doesn’t remember the “super-solvent” and “kits” to make your own juice.

At first bodybuilders had to find out which solvents, co-solvents and preservatives had to be used and in which concentration. I’ve had many infections, scartissue and red lumps. Once more and more underground laboratories stepped into this flourishing market, also chemists where hired to overcome the problems.

Manufacturing

As I said before all chemicals in the complete injectable will influence its pharmacokinetics, scientific research proves it could even stretch the half life of the active ingredients. Most of these researches where performed to restore sex hormone levels in elderly people. Its called hormone replacement therapy (HRT). I'll adress it later in a future article

Just recently I jeard from a chemists how to solve oral alkylated compounds using a system called cold wetting. I had never heard of it and decided to try to solve methandrostenolone and Testosterone base API (raw powder) just like the above, but then with less agressive solvents and co-solvents. It really did work great, both the Test Base as well as the Methandrostenolone. The testosterone partly cristalised after a few days, but the Methandrostenolone stayed clear at 200 mg/ml just as the 50/50 Methandrostenolone/Testosterone base. I will experiment some more with Oxymetholone, Stanozolol and combinations. I will also try them om some human guinae pigs to record the gains "in vivo".

Liver toxity

Many 'experts" state that even when 17-alpha-alkylated steroids are administrated sub-q or intra muscular they still have livertoxcity and have to go through a first or second pass through the liver. I'll adress it in an article.

Drugs can be given as soluble tablets, as an elixir, as rectal suppositories, subcutaneously (SC), intravenously (IV), and intramuscularly (IM). Although there are various methods of taking drugs, injection is favoured by most users, it also bypasses first-pass metabolism in the liver, resulting in a higher bioavailability for many drugs than oral ingestion would (so users get a stronger effect from the same amount of the drug).

Morphine has a strong "first pass effect" when given orally. Thus, the oral to parenteral potency ratio is given as 6:1 for a single dose. With chronic administration, this first pass effect lessens, and the oral to parenteral potency ratio is 3:1. It is metabolized in the liver and excreted with active metabolites by the kidneys.

Basic Pharmacology

//www.nurse-prescriber.co.uk/education/modules/pharmacology/pharmacy3.htm

A profile from the net:

Dianabol is the most popular oral steroid used by athletes for gaining overall mass. The chemical name for Dianabol is Methandienone or also known as Methandrostenolone.

Methandienone is a derivative of testosterone, testosterone which has an androgenic/anabolic ratio of 100 : 100. The hormone has been modified so that the masculinizing androgenic properties are reduced and the tissue building anabolic properties are increased giving it a androgenic/anabolic ratio of 40 - 60/90 - 210.

Methandienone weakly binds to the androgen receptor (AR), the effects it produces are dramatic increases in the protein synthesis, glycogenolysis and muscle strength.The dianabol user will also experience an increased aggression which will be beneficial in a heavy gym workout. Users can expect to gain at least 2 – 4 pounds per week for a period of 6 - 8 weeks with dianabol, a total weight gain of 12 – 32lbs.

Dianabol is administered orally in a daily dosage in the range of 15 – 50mg. The most effective dose of Dianabol is 50mg/day. It has been discovered through trial and error that taking a lower dose than this will produce less results, and subsequently taking more than this will produce no further results other than negative side effects.

To maintain a balanced concentration of Dianabol in the blood it is best to split the dosage between 5 - 20mg, first taken from awakening, and yet again every four hours. So for example if you were taking 50mg/day, you would take 20mg on awakening, then twice 10mg, and then finally 10mg later to complete your daily intake. The reason for doing this is because Dianabol has a half life of between 3 to 5 hours. For maximum utilization of Dianabol it is best taken on an empty stomach, studies have shown that taking an oral anabolic steroid with food may decrease its bioavailability.

Dianabol is aromatized by the body, and is a moderately estrogenic steroid. Users sensitive to high levels of estrogen may notice puffiness or swelling under the nipple which is accompanied by pain or soreness. These are the symptoms of Gynecomastia the medical term for the development of female breast tissues in the male body. To fight this side effect it is necessary to add the addition of an estrogen antagonist such as Nolvadex or Clomid, or an aromatase inhibitor such as Arimidex. The aromatase inhibitor Arimidex is the most effective option but also the most costly.

A higher level of estrogen can also result in increased water rentention in the Dianabol user. The androgen can increase the amount of water and sodium stored in body tissues and can bring about a very bloated appearance in the body, which in turn will reduce the visibility of muscle definition. A high level of water retention can lead to high blood pressure and kidney damage. If water retention becomes a problem when using Dianabol the use of an anti-estrogen such as Nolvadex and/or Proviron may help to minimize it. Again an aromatase inhibitor such as Arimidex can also be used. Water retention is also beneficial when stored in muscles, joints, and connective tissues as it will help improve the individuals overall strength. The excess water retention can also help to prevent injury on heavier lifting.

Dianabol users may experience more oily skin due to the sebaceous glands which secrete oils in the skin being stimulated by the anadrogen. Increasing these hormone levels in the skin will produced increased oil output which will, often result in acne on the face, back and shoulders. One medicine which is commonly used to fight against acne is Accutane, which works on the sebaceous glands causing them to reduce the level of oil secreted.

Methandienone has been chemically altered enabling it to be administered orally allowing the highest potency of the drug to flow into the bloodstream. The hormone is therefore called c17 alpha alkylated compound which means a hydrogen atom at the steroid's 17th alpha position has been replaced with a carbon atom (a process called alkylation), this would make the hormone harder to break down in the liver. C17 alpha alkylated compounds can be hepatotoxic, which means with prolonged use or high exposure may result in liver damage. Therefore it is best to limit your Dianabol cycles to a period of between 6 to 8 weeks to avoid escalating liver strain. When running Dianabol is recommended to stack it with a herbal liver supplement such as Milk Thistle which can be picked up locally.

Dianabol has effects on the Cardiovascular system on serum cholesterol. This includes a tendency to reduce HDL (good) cholesterol values and increase LDL (bad) cholesterol values, which can increase the risk of cardiovascular disease.

Dianabol will suppress endogenous testosterone production. When the body receives an androgen from an outside source this will result in a surplus of the hormone and the body will therefore stop to produce its own testosterone. If the hypothalamus detects a high level of sex steroids it will shut of the release of GnRH (Gonadotropin Releasing Hormone). This will result in the pituitary to stop releasing LH (luteinizing hormone) and FSH (follicle stimulating hormone) the two hormones that stimulate the leydig's cells in the testes to produce testosterone. Without the stimulation of LH and FSH, the testes will be in a state of production limbo, and may shrink from inactivity. After a Dianabol cycle testosterone levels should begin to return to normal within 1- 4 months without the use of testosterone stimulating drugs. HCG can be used during a Dianabol cycle to maintain testicular activity and size.