Myostatin

The research towards the myostatin inhibitor ACE-031 was terminated - but it does work

The pharma companies Acceleron Pharma and Shire have put the myostatin inhibiter ACE-031 on ice. That have indicated. [Acceleronpharma.com May 2, 2013] And that's pretty weird. Them in a joint press release a few days ago

A few weeks earlier, Muscle & Nerve published a study showing that ACE-031 is a compound which a chemical bodybuilder would gladly add to his toolbox.

The injectable ACE-031  is a synthetic activin receptor type IIB. Muscle cells have that receptor too. It is intended for proteins as myostatin, GDF11 and activin A and B. If myostatin docks itself to the activin receptor type IIB, then the growth of muscle fibers reduces. Under the 'right' circumstances myostatin even breaks down muscle.

If you inject ACE-031, then that does not happen. The synthetical activin receptor type IIB captures the muscle inhibitory proteins away, and disable them.

 

Wendy the whippet  …

So I’ve been thinking a bit lately about individual genetic profiles, determinism, and sporting prowess; the specific genetic hand we’re dealt, and how best to play that hand within the limitations of the real world.  First off, how about a little visual representation of what a mutation to a single gene (actually, the non-presence of the GDF-8 gene) can cause in an otherwise similar breed of dog.  GDF-8, by the way, is responsible for signaling the production of myostatin, which, in turn, is responsible for limiting the amount of muscle production in an animal.  Myostatin works the same way in humans as it does in these whippets.  GDF-8, while being yet another stroke of evolutionary genius (muscle mass past a certain point is an unnecessary metabolic drag, i.e., survival limiting), is an area of obvious interest within the physical culture community.

No PhotoShop here, folks; just a dramatic demonstration of the effects genes can have upon muscling and athletic prowess.  And this is a representation of what affects a single gene mutation can signal.  What I find interesting is that if Wendy were a human, we’d just assume that she was much more dedicated in following her (fill in the blank) workout regimen; being that she’s a dog, though, we’re ok with the fact that she’s come by her appearance the old fashioned way — i.e., via inheritance.  By the way, here’s an interesting video from Wendy, the defacto spokes-pooch of bully whippets.  A normal whippet in every way, except in skeletal musculature.  I find it very sad that appearantly these animals are normally euthanized at birth (I’m assuming because they are not charactoristic of the AKC whippet?).

Beautiful buttock sheep and the legacy of Solid Gold 

Comparing human and sheep genomic sequences reveals six imprinted genes at the callipyge locus 

  The mutation appeared to be a miracle. Sheep breeders in Oklahoma had been selecting for increased muscle in their flock, and in 1983 a lamb was born that developed an overly muscular rump. The breeders named the ram Solid Gold and saved him from slaughter. He went on to sire offspring with the pronounced hindquarters, some of which also passed on the mutation. These sheep became known as callipyge, the name callipyge comes from the Greek for 'beautiful buttocks'. All born since are his descendants.They're Arnold Schwarzenegger-shaped, and their meat's tougher than hell.

Scientists Hot on Gene Doping Trail

 therapy and gene-targeting therapeutics were mostly a matter of medical prediction. Since then, they’ve moved to the edge of medical reality. Most advances are still limited to lab animals, but that hasn’t stoppedAfter warning for years that athletes would try to dope their genes, scientists are finding ways to catch them. The tests are still being refined in animals, but will likely be run years from now on samples taken at the upcoming Winter Olympics and stored.