A case of toxicity from DMAA party pills in New Zealand

This is  an incident but since we post a lot about DMAA I thought to let you know

‘Party pills’ are synthetic stimulants that emerged in New Zealand in the early 2000s. Most were 1-benzylpiperazine (BZP)-based and were widely consumed. Evidence accumulated of risk and toxicity and BZP was subsequently scheduled.1,3

Dimethylamylamine (DMAA) is one of the next generation of ‘BZP-free’ party pills.

This report describes a case of a serious complication associated with the recreational use of DMAA.

Case report

A 21-year-old man was out with friends and purchased a quantity of legal party pills identified as ’99.9%-pure DMAA’. He took the recommended dose of 2 tablets at approximately 11:30 pm along with a capsule identified as 150 mg of caffeine. He had already ingested 1 can of beer.

Within 30 minutes he developed a severe global headache and called for a friend to take him home. He subsequently became confused, incontinent of urine and vomited for 2–3 hours before falling asleep. The next morning he was drowsy and had slurred speech. He did not improve during the day so at 6 pm he was taken to the local hospital emergency department (ED).

Figure 1. DMAA capsules and packaging (brand name obscured)

On arrival in the ED he was confused and had slurred speech. He was disorientated in time but not person or place. He could not give a coherent history. He had a right facial droop and right-sided weakness. There was no sympathomimetic toxicity evident, however 19 hours had elapsed since ingestion. His heart rate was 65 bpm and blood pressure was 126/66 mmHg.

The many faces of Trenbolone

You can find many articles on the internet about Trenbolone and mostly the writers will tell you that all Trenbolones are equel (they have the same parent compound, right?). The only difference is their half-life due to their estrification and therefore also the active compound will differ due to the molecular weight of the estrification.

Confusing, maybe but during this article I’ll try to explain clearly for all to understand.

Its not only the esterifications that are responsible for the strength effect of these copounds, but also the carriers, the solvents, co-solvents and the concentration. Where one of these Trenbolones like the Trenbolone Enanthate is effective in milligrams per millilitre, an other like Metribolone is allready active in microgrammes. Accourding to VIDA, Oral-Trenbolone (Metribolone or Methyltrienolone) has an androgenic/anabolic ratio of 6,000-7,000 /12,000-30,000 as compared to Trenbolone Acetate/Enanthate 500/ 500.

I plan to update this article on a weekly basis for a long time since I have an enormous amount of data on this subject. If aanyone wants to contribute..I'd appreciate it. You can comment here or in the forumthread on blog section

Former University of North Dakota Football Players Linked to Anabolic Steroids

Law enforcement officers have recently been busting college athletes who use steroids even when the steroid testing program administered by the National Collegiate Athletic Association (NCAA) has failed to detect the use of such drugs. Police in Grand Forks County recently uncovered anabolic steroids at the home of three players for the 2011 University of North Dakota football team.

Frontloading

There is a lot of scrutiny regarding proper anabolic-androgenic steroid cycle structure for maximal muscle gains with minimal risks. Front loading is one practice gaining attention in the bodybuilding community. This process immediately elevates blood androgen levels. Front loading omits the customary delay of obtaining peak and stable blood levels by increasing the cycle’s front-end use.

Athletes stumble onto AAS use while scavenging for further ways to promote a progressive strength training routine – especially bodybuilders and powerlifters. Strength athletes often search for ways to develop productive steroid cycling protocols by combining the clinical research that is available with personal experience; as well as gathering insight from others. Formal clinical trials analyzing anabolic steroids in sports and exercise are rare. The medical community perceives little application for large performance-enhancing amounts of AAS to treat disease – even though many athletes would argue poor performance is an adverse health condition. Mostly through trial and error, numerous informal studies and private research examines various steroid cycling methods and how they can present a positive impact on performance and body composition. This information is generally shared through social networks, to include using online messaging software.

Pharmacokinetics and Pharmacodynamics of Steroid Esters in Oil Vehicle:

Effects of Ester, Injection Site, and Injection Volume

Variations in side-chain ester chemistry are important in the pharmacokinetics of androgen esters in oil vehicle. In humans, the very short propionate (three-carbon aliphatic) ester of testosterone has distinctly shorter duration of action than esters with longer (seven- or eight-carbon) side-chains. More subtle changes in side-chain ester structure have proven ineffective in altering human clinical pharmacokinetics, because substitution of a linear aliphatic side-chain of seven carbons (enanthate) with either a saturated, cyclized, seven-carbon aliphatic chain (cyclohexanecarboxylate) or a linear, aliphatic, eight-carbon chain (cypionate) resulted in virtually unchanged kinetics. (2, 4-6, 12, 15)