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GW 1516 is often used in a "synergistic" combo with Aicar. Is it worth anything for bodybuilders. What do the analyses of black market analyses say. These chemicals are yet very hot and many "research chemicals" rave about it on forums (often as the sponsor). But is a fat or does it contribute to our chemical toolbox?

GW-1516 (also known as GW-501,516,GW501516 or GSK-516) is a PPAR 948; modulator compound being investigated for drug use by GlaxoSmithKline.[1][2] It activates the same pathways activated through exercise, including PPAR 948; and AMP-activated protein kinase. It is being investigated as a potential treatment for obesity, diabetes, dyslipidemia and cardiovascular disease. [3] [4] GW-501516 has a synergistic effect when combined with AICAR: the combination has been shown to significantly increase exercise endurance in animal studies more than either compound alone. [5][6]

GW-50156 regulates fat burning through a number of widespread mechanisms [7]; it increases glucose uptake in skeletal muscle tissue and increases muscle gene expression, especially genes involved in preferential lipid utilization.,[8][9] [10] This shift changes the body's metabolism to favor burning fat for energy instead of carbohydrates or muscle protein, potentially allowing clinical application for obese patients to lose fat effectively without experiencing muscle catabolism or the effects and satiety issues associated with low blood sugar. [11] GW-501516 also increases muscle mass, which improved glucose tolerance and reduced fat mass accumulation even in mice fed a very high fat diet, suggesting that GW-501516 may have a protective effect against obesity [12]

The idea of steroids having direct fat burning properties is a commonly held belief among steroid users. This is why bodybuilders use steroids also during dieting, so they can maintain more muscle and lose more fat. How does anabolic steroids help burn fat, is it direct or indirect and what type of fat. I’ll help try to answer these questions.

Steroid fat loss studies

Unfortunately, most of the studies on fat loss and steroids is done on cattle. It’s a pretty scientific way of looking at it since it’s a controlled environment and they don’t do anything unique that might alter results.

In a study published in J Anim Sci. 2007 Feb;85(2):430-40 they measured carcasses of steers and cattle after they had been implanted with Synovex-Plus (SP), which is testosterone. This study shows that anabolic implants do not appear to have direct effects on intra-muscular lipid deposition. In other words implanting did not change the bodyfat percentage of visceral fat, the fat inside or around the muscles.

Another study J Anim Sci. 1999 May;77(5):1100-4 used implanted steroids trenbolone acetate plus estradiol benzoate ot progesterone at various times and dosages over 2 months. They found no significant differences on intramuscular lipid content.

Notice in those studies that they are talking about intramuscular fat. Its been theorized by many that steroids do a bad job of stopping intramuscular or “visceral fat”. However, they do seem to help promote fat loss overall. This is done by losing fat subcutaneously, which is the fat under the skin, which you can visually see.

A study published in J Anim Sci. 1996 Aug;74(8):1770-6. compared control cattle to three other groups; those implanted with trenbalone acetate, implanted with testosterone propionate +20 mg of estradiol benzoate, or both implants. This study found that groups all gained weight and lost fat(were leaner cows). Interesting enough they found the cows that had been implanted with 200 mg trenbolone acetate only, were the leanest.

Clenbuterol.. Hard Core Bodybuilding done safe

Clenbuterol is a very potent compound it works in micrograms (1/1000^th of a gram). Therefore it’s very hard to dose it correctly. Many Underground Labs have inconsistent dosing. The label claims 20 mcg per tablet, but some tablets contain almost nothing while others are too high dosed. Some Chinese compounders ‘ solved” that problem by overdosing their tabs resulting in unwanted visits at the emergency room in the hospital. Production of tablets and API (raw powder) of Clenbuterol is no longer allowed in China since  September 2012.

In the last few years Clenbuterol (clenbuterol hydrochloride) has replaced Ephedrine HCL (hydrochloride)  as the drug of choice when it comes to fat loss and contest preparation in general. Clenbuterol is used throughout the world as a bronchodilator for asthma patients. In terms of fat loss, ‘Clen' (as it's frequently called) is what's known as a "repartitioning agent" - an agent that increases your ratio of lean muscle mass to fat mass.
 

Peptide Guide :

1 - You are on this site because you have heard of and want to become more familiar with Growth Hormone Releasing Peptide (GHRP) and/or Growth Hormone Releasing Hormone (GHRH). These 2 materials administered can give you an increased quality of life in ways of anti-aging, muscular hypertrophy, fat loss, injury repair, higher bone density, and better sleep.

2 - GHRP can be used on its own to increase our natural Growth Hormone (GH) pulse release from the Pituitary Gland in the brain. GHRP dosed in conjunction with GHRH will amplify our growth hormone release significantly to gain maximal benefit.

3 - There are various types of GHRH's. The only GHRH to consider is tetra-substituted CJC-1295 / CJC-1295(without DAC) / modGRF(1-29). They are all the same thing but with a different name. They come in vials ranging in material weights measured in milligrams (mg) consisting of a solid freeze-dried (lyophilized) substance.

4 - There are various types of GHRP's. GHRP-6, GHRP-2, Hexarelin, and Imaporelin. The differences between them are potency and side effects. GHRP-6 is very potent and makes you quite hungry. GHRP-2 is potent and can slightly affect your sleep somewhat. Hexarelin is very potent but you can desensitize from higher dosages. Imaporelin is potent with the minimalist side effects of all 4 GHRP's.

5 - Peptides are dosed via a regular 1mL needle syringe typical to what a diabetic would use. It is administered Subcutaneously (SubQ) (just under the skin into the fat tissue), most usually around the abdomen region.

6 - The required amount (saturation dose) is 1mcg (microgram) per Kg (Kilogram) of bodyweight. The typical usage and for ease of measuring is 100mcg of modGRF(1-29) and/or 100mcg of your choice of GHRP. Lower dosages will simply result in less GH release due to a slightly weaker GH pulse and reduce any side effects you may have. A higher dose will have minimal benefit and is more a waste of money than anything else. But, in saying that, the more frequently dosed in any given day would result in more frequent pulses.

Have you had your flavonoids today?

While not a question normally asked at a social gathering, flavonoids have become quite a hot topic in the media and in scientific journals.

Flavonoids help protect plants by shielding them from environmental toxins and helping repair damage. When we consume plant-based foods rich in flavonoids, it appears that we also benefit from this “antioxidant” power. Antioxidants are believed to help the body's cells resist damage caused by free radicals that are formed by normal bodily processes such as breathing and from environmental contaminants like cigarette smoke. When the body lacks adequate levels of antioxidants, damage from free radicals occurs and leads to increases in LDL (“bad)-cholesterol oxidation (oxidized LDL-cholesterol hurts the arteries) and plaque formation on the walls of the arteries.

Flavanols are the main type of flavonoid found in cocoa and chocolate. In addition to having antioxidant qualities, research indicates that flavanols have other positive influences on vascular health, such as lowering blood pressure and improving blood flow to the brain and heart, making blood platelets less sticky and able to clot, and lowering cholesterol.