Aicar

 kfsdjhgdshjhhhaawwweeaaa aaaa Since the times of the first, ancient Olympics, since the dawn of sports people have been cheating. That was then and that is now. Anti-doping organizations and sports associations are constantly chasing dopers who resort to more radical means every time. The lengths to which these “athletes” go to get an advantage is sometimes shocking. They are literally putting their lives in danger by experimenting with non-clinically tested drugs.

This blog post is meant to give an insight in the newest doping products that are out there on the market and to show how hard it is to actually detect these. And how scientific progress is often misused by cheaters. The sources I used are all scientific and can be send upon request.

In 2008, Cell published an article which was looked on with interest by the world of sports. Professor Ron Evans of La Jolla, California was doing research to find a cure for the increasing epidemic of obesity and diabetes. He found a substance that would trick the cells in thinking they exercised a lot while in fact they had been mostly idle. The mice ran faste, had better endurance and burnt fat.

When the mice were actually following a training regime the results almost doubled. The media dubbed it the “coach-potato drug”, the miracle cure to obesity and diabetes for people who were unable to exercise.

GW 1516 is often used in a "synergistic" combo with Aicar. Is it worth anything for bodybuilders. What do the analyses of black market analyses say. These chemicals are yet very hot and many "research chemicals" rave about it on forums (often as the sponsor). But is a fat or does it contribute to our chemical toolbox?

GW-1516 (also known as GW-501,516,GW501516 or GSK-516) is a PPAR 948; modulator compound being investigated for drug use by GlaxoSmithKline.[1][2] It activates the same pathways activated through exercise, including PPAR 948; and AMP-activated protein kinase. It is being investigated as a potential treatment for obesity, diabetes, dyslipidemia and cardiovascular disease. [3] [4] GW-501516 has a synergistic effect when combined with AICAR: the combination has been shown to significantly increase exercise endurance in animal studies more than either compound alone. [5][6]

GW-50156 regulates fat burning through a number of widespread mechanisms [7]; it increases glucose uptake in skeletal muscle tissue and increases muscle gene expression, especially genes involved in preferential lipid utilization.,[8][9] [10] This shift changes the body's metabolism to favor burning fat for energy instead of carbohydrates or muscle protein, potentially allowing clinical application for obese patients to lose fat effectively without experiencing muscle catabolism or the effects and satiety issues associated with low blood sugar. [11] GW-501516 also increases muscle mass, which improved glucose tolerance and reduced fat mass accumulation even in mice fed a very high fat diet, suggesting that GW-501516 may have a protective effect against obesity [12]