Veterinary steroids and implants

Not too long ago many bodybuilders relied on certain veterinary steroids only, because substances such as Equipoise (boldone undecylenate) , Trenbolone acetate and injectable Winstrol (stanozolol) were only available as veterinary compounds. The only downside of using these veterinary means was the low dosage. Equipoise at 50 mg/ml, Trenbolone Acetate at 30 mg/ml etc. The same was also true for the Australian vet steroids.

Implants

The hormone implants, keenly marketed by the pharmaceutical giants, boost growth rates in steers and heifers by up to 30 per cent. Put simply, a $4 cartridge, implanted behind the ear and lasting about three months, typically returns at least 10 times that value in extra meat, less fodder and saved time. Cattle is chronically exposed (68 ± 20 days) to a steroid hormone implant containing 200 mg trenbolone acetate and 20 mg estradiol (Revalor-H). This seems very little for such a big animal, but still it has been proven to be enough.

Synovex is a steroid implant preparation, which is available only as a veterinary item for use in cattle (livestock). The implant comes in the form of small pellets, which are pushed into the ear of an animal with a large implant gun. Here they slowly dissolve and provide an extended release of steroid, lasting for many weeks. The hormone content of Synovex is mixed, with each pellet containing 25mg testosterone propionate and 2.5mg Estradiol Benzoate. The number of pellets in each cartridge will also vary depending on the intended target. Implants denoted "H" for heifer carry the most; in the case of U.S. Synovex-H it is 80 pellets (10 doses consisting each of 8 pellets). We will see a slightly lower pellet count in the "S" implants (steer) and "C" (calf) cartridges. 

The combination of estrogen with testosterone (in a 10:1 ratio) has proven to provide an added anabolic/weight gaining effect in feed animals. Athletes have long been aware that strong androgens like testosterone, which aromatize into estrogen quite readily, are the strongest anabolics. It is also observed that anti-estrogen drugs like Nolvadex can decrease the muscle and strength gains received from androgen therapy. It has been therefore theorized that the added estrogen level is in some way responsible for increasing the anabolic effect of androgens. Perhaps this is accomplished by somehow increasing the number of available receptor sites or receptor sensitivity.

With this understanding one might think the estrogen combination in Synovex would prove to be a powerful mix for athletes. But those who have experimented with it have been generally disappointed with the results, as the estrogen in this product is very likely to produce many unwanted side effects. This includes severe gynecomastia, noticeable body fat accumulation and water retention. In many cases the water retained will lead to an unsightly bloated look (extreme loss of definition). Synovex is clearly a good cattle item, but not the ideal steroid for humans. I really think athletes have only become attracted to this product out of sheer desperation for legitimate anabolics. Here in the United States, cattle implants like this are not controlled substances despite their steroid content. Synovex is often easy to purchase directly from Agricultural or Veterinary supply stores, as no paperwork is required.

Any athlete who uses an implant containing estradiol will rapidly find themselves shopping for comfortable bras (gynecomastia). No amount of anti-estrogen can block the effects of the large amount of female hormone contained within these implants. The usage of an anti-aromatase would also be useless as the estrogen is already there. The only way to effectively use these implants is to remove the estradiol component prior to administration.

An athlete will typically grind up these pellets, and either rub them on the skin mixed with DMSO and water for transdermal delivery, or mix up his own injection. One should remember that the practice of preparing this for injection would obviously not be very sterile and could be potentially dangerous. Others feel that simply snorting the Synovex powdered is a sufficient delivery method. Some have additionally worked out methods of removing the estrogen from the pellets, to make the drug much more comfortable to use.

It is also possible to buy complete kits. Using one of these kits are a must before using either Synovex or Implus-H. These kits will not remove 100% of the estrogen contained within the implant so concomitant use of an estrogen blocker is required. While all this is possible, I think such procedures are generally much more trouble than they are worth. They involve the use of highly flammable materials, and take a number of different steps to complete. All of the estrogen will likely not be removed after all is done, and I cannot see the end product as being the most sanitary thing to administer. In addition to the U.S. version made by Syntex, Synovex is also available in other countries.

Underground Labs (UGL’s)

Other hot items were the Australian steroids that contained Methandriol Dipropionate. Though many “guru’s” doubted, or simply denied their potency bodybuilders loved them. Why? Because they simply work. Most “guru’s” form their opinion theoretical, in reality they never took these roids or worked with athletes that really took them.

Beyond I’ll post what Bill Roberts had to say about these combinations. Other negative opinions can be easily found via search engines. Dan Duchaine loved MD and hypothesized about “receptor-cleaning” properties. And not everyone liked DanD and his opinions.

“The king is dead..long live the new king”

When it became harder and harder to purchase these items from Australia and later Mexico, UGL’s filled the gap.

I advised Hard Core Labs (HCL) to run an injectable Methandriol Dipropionate (MD) and mixed compounds with MD, such as Overdrive and Nuclear Blast. I didn’t advised it just on “real life” results, but there has been done some intensive research towards MD, just read my article here:

//juicedmuscle.com/jmblog/content/methandriol-dipropionate-0

As with most veterinary AAS the disadvantage with RWR mixed compounds is their low dosage.

The active Ingredients in DRIVE are 25mg/ml Boldenone Undecyclenate and 30mg/ml Methandriol Dipropionate. Hard Core Labs makes OverDrive with 50 mg/ml Methandriol Dipropionate and 150 mg/ml Boldenone Undecyclenate

Profile:

Methandriol Dipropionate (MD) is a form with a longer action, presented in an oily solution for injections and pills. The steroid has a significant anabolic and androgen action and it is known as a good way of force and musculature increase.

As well as the testosterone, Methandriol befriends a good force and musculature increase and it doesn’t accumulate water more than the Deca-Durabolin. Although, the best performances are obtained by using it in association with any other steroid, because it had been observed that the Methandriol Dipropionate steroid has the capacity to intensify the action of other concoctions.

That’s why injectable Methandriol Dipropionate is recommended to be used only in combination with other “chemical” substances from different steroids.

Injectable Methandriol Dipropionate can be found only in Australian vet steroids : Drive, Spectriol, Geldabol, Tribolin 75, Protabol, Filibol and others so its procurement is a complicated problem.

The athletes who use those drugs have a good force and musculature increase and a reduced water accumulation. The injectable form is less aromatized and less toxic. The most frequent dose used  is 100 mg for 2-3 days.

Bill Roberts: “Methandriol dipropionate, used in some Australian veterinary products, is to be avoided by male bodybuilders. It is highly estrogenic, and has no redeeming properties. Methandriol is a poor anabolic and the mythical “receptor-cleaning” properties that have been claimed for it are pure fantasy.”

“An anti-aromatase would not correct the estrogenic problems of methandriol dipropionate, since it is directly estrogenic, not requiring conversion by aromatase. An anti-estrogen such as Clomid would probably help, but since methandriol is a poor anabolic anyway, there is no point to a methandriol/Clomid stack.”

When considered as a single tissue, skeletal muscle makes up 50% of the mass of most mammals and contributes 25% to basal energy expenditure. Consequently, in addition to locomotor performance, muscle growth rate has a major influence on the metabolic efficiency of the whole animal. This is of particular interest to those industries whose primary focus is on the efficient production of muscle, such as the beef industry. Sex steroids are widely used in some parts of the beef industry to increase yield and efficiency of growth .

There are multiple lines of evidence linking the sex steroids, testosterone AND estrogen, to increased muscle mass in mammals. For example, human sexual dimorphism in muscle mass emerges during late puberty, coincident with a surge of endogenous testosterone in males. Similarly, hypogonadal men who produce lower levels of endogenous testosterone have reduced muscle mass compared with their eugonadal counterparts. Exogenous administration of both testosterone and estrogen influences muscle phenotype in humans. Supraphysiologic doses of androgens have been core components of doping programs in elite power sports for decades. Testosterone has been shown to induce muscle hypertrophy and lead to increases in voluntary strength. Estrogen has been shown to stimulate muscle repair and regenerative processes, although the extent and direction of the muscle response does seem contingent on species and circumstance. Bones

Because final muscle fiber number is set prior to birth in most mammals, postnatal muscle growth normally occurs by hypertrophy of existing fibers. In order for these existing fibers to expand, they require additional nuclear material. In many instances of adult muscle growth and regeneration, the additional nuclear material is supplied by a population of normally quiescent satellite cells that lie outside the myofibers. Notable exceptions to this observation include the myostatin blockade, which is initially independent of satellite cell activation. Nevertheless, proliferation of satellite cells is activated by sex steroid treatment and is thought to contribute to steroid induced muscle growth.

In broad terms, the mechanism by which sex steroids mediate their growth promotant effect is thought to be both direct, i.e., by binding to the androgen and estrogen receptors expressed by muscle itself, and also indirect, by inducing other circulating growth promoting substances that then secondarily stimulate muscle growth. Evidence for direct action includes the fact that exogenous steroids elicit an allometric pattern of muscle growth in line with androgen and estrogen receptor density, with the more dramatic phenotype in muscles with higher sex steroid receptor densities. Evidence for indirect action comes from the observed induction of other known anabolic agents following steroid treatment. For example, treatment of soleus, a predominantly slow twitch muscle, from aged castrated rat, with 5α-dihydrotestosterone induces IGF1 and the IGF1 splice variant mechano-growth factor within 24 h, leading to a molecular switch to a more type II muscle phenotype. Similarly, treatment of young castrated cattle with estradiol-17β increases the levels of growth hormone (GH) and IGF1 in plasma.

Despite this range of evidence, the exact molecular mechanism(s) through which sex steroids exert their growth promotant effect has not been fully delineated. The use of different mammalian models, different time frames, different muscles, in vitro as well as in vivo circumstances, different combinations of treatments, and different downstream assays has undoubtedly confounded interpretation. Here, we aim to fill in some of this molecular detail by examining the combined impact of the slow release, synthetic highly androgenic trenbolone acetate and the estrogenic estradiol on an epaxial skeletal muscle in cattle.

Stimulation of both estrogen and androgen receptors maintains skeletal muscle mass in gonadectomized male mice but mainly via different pathways. Svensson et all 2010:

“Testosterone is a major regulator of muscle mass. Little is known whether this is due to a direct stimulation of the androgen receptor (AR) or mediated by aromatization of testosterone to estradiol (E(2)), the ligand for the estrogen receptors (ERs), in peripheral tissues. In this study, we differentiated between the effects mediated by AR and ER by treating gonadectomized male mice for 5 weeks with E(2) or the non-aromatizable androgen dihydrotestosterone (DHT). Both E(2) and DHT increased muscle weight and lean mass, although the effect was less marked after E(2) treatment.”

I post this piece of research to remind you about the fact that not all Estrogen is bad, you need some for heaqlthy bones, healthy blood lipid values and what I mean to make clear with this blogpost.. it is ANABOLIC, it doesn’t just causes sides like female pattern fat accumulation, fluid retention (bloat), bitch tits (gynecomastia) etc etc. So don’t block it completely!!

Australian veterinary steroids:

Androbol
Manufacturer: Ranvet Pty Ltd
Composition: Each mL contains nandrolone decanoate 25mg, methandriol diproprionate 35mg, testosterone enathate 20mg
Presentation: 10mL vial

AVP-Supertest
Manufacturer: Advance Veterinary Products Pty Ltd
Composition: Testosterone Propionate 50mg/mL in arachis oil
Presentation: 10mL vial

Boldebal-h
Manufacturer: Illium Veterinary Products
Composition: Boldenone undecylenate 50mg/mL
Presentation: 10mL vial

Boldenone 50
Manufacturer: Jurox Pty Ltd
Composition: Boldenone undecylenate 50mg/mL
Presentation: 10mL vial

Depobol
Manufacturer: Jurox Pty Ltd
Composition: Boldenone undecenoate 50mg/mL in arachis oil; benzyl alcohol 5% as preservative
Presentation: 10mL vial

Drive
Manufacturer: RWR Veterinary Products Pty Ltd
Composition: Boldenone undecylenate 25mg/mL, methandriol diproprionate 30mg; oil base
Presentation: 10mL vial

Dynabol 50
Manufacturer: Jurox Pty Ltd
Composition: Nandrolone cypionate 50mg/mL in arachis oil; benzyl alcohol 0.05 mL/mL as preservative
Actions: Anabolic/ androgenic ratio of 9.3 to 1. Enhances haematopoietic function. Increases red blood cell counts and haemoglobin levels over a 27 day period by 12% and 9% respectively.
Presentation: 10mL vial

Filybol
Manufacturer: Ranvet Pty Ltd
Composition: Nandrolone Decanoate 30mg/mL, methandriol diproprionate 40mg
Presentation: 10mL vial, 20mL vial

Filydoc
Manufacturer: Ranvet Pty Ltd
Composition: Each mL contains deoxycortone enathate 20mg, methandriol diproprionate 40mg, nandrolone decanoate 30mg in oily solution; benzyl alcohol 50mg/mL as preservative
Presentation: 5mL vial, 10mL vial

Geldalbol
Manufacturer: Jurox Pty Ltd
Composition: Nandrolone cypionate 25mg/mL, methandriol diproprionate 35mg/ml, testosterone enathate 20mg/ml; benzyl alcohol 5% v/v as preservative
Presentation: 10mL vial

Laubal-H
Manufacturer: Illium Veterinary Products
Composition: Nandrolone laurate 50mg/mL.
Presentation: 10mL vial

Laurabolin
Manufacturer: Intervet (Australia) Pty Ltd
Composition: 19-Norandrostenolone laurate in oily solution
Presentation: 25mg/ml 10ml vial, 50mg/ml 10ml vial

Metabolin
Manufacturer: Jurox Pty Ltd
Composition: Nandrolone cypionate 35mg/ml, methandriol dipropionate 40mg/ml in arachis oil; benzyl alcohol 5% as preservative
Presentation: 10ml vial

Nandoral
Manufacturer: Intervet (Australia) Pty Ltd
Composition: Ethyloestrenol 0.5mg
Actions: Anabolic steroid specifically designed for oral use to complement Nandrolin and Laurabolin ; a potent anabolic. Virtually no androgenic activity whilst the steroid's anabolic activity is retained. Metabolically, Nandoral encourages nitrogen and calcium retention and has strong anticatabolic effects.
Presentation: Tablets; 100's, 500's, 50mg/per tab

Nandrabolin
Manufacturer: Jurox Pty Ltd
Composition: Nandrolone cypionate 30mg/ml, methandriol dipropionate 45mg/ml
Presentation: 10ml vial

Nandrolin
Manufacturer: Intervet (Australia) Pty Ltd
Composition: Nandrolone phenylpropionate in oily solution
Actions: A testosterone derivate with very marked anabolic and anticatabolic action whilst, in the recommended therapeutic dosage, it has negligible androgenic or progetogenic activity. It has a positive effect on nitrogen, calcium and phosphorus metabolism. Levels of sodium, potatssium and alkali reserve, as well as water content in tissues are promoted and maintained.
Presentation: 20mg/ml: 10ml vial; 50mg/ml: 25ml vial

Nitrotain
Manufacturer: Biochemical Veterinary Research Pty Ltd
Composition: Ethyloestrenol 15mg/4g
Actions: Aanabolic steroid with extremely high anabolic to androgenic index (relative to testosterone = 1, ethyloestrenol index is 19, stanozolol 3.8, nandrolone 4). Orally active steroid which enhances protein synthesis and diminshes urinary nitrogen excretion. Anti-catabolic effects, stimulation of appetite and haematopoiesis, and a positive effect on calcium, phosphorus and potassium metabolism occur when nutrition is adequate. Androgenic effects or gonadrotropic supression are unlikely at recommended dosages.
Dosage: 1 syringe graduation = 4 g. For Gonadal replacement, anticatabolic, appetite and haematopoietic indications: 4g/450kg horse daily. For repair indications: 8g/450kg horse daily.
Presentation: Paste (syringe): 60g

Norabolin 50
Manufacturer: Jurox Pty Ltd
Composition: Nandrolone laurate 50mg/mL
Actions: Long acting anabolic steroid with low androgenic effect
Presentation: 10mL vial

Novatrol
Manufacturer: RWR Veterinary Products Pty Ltd
Composition: Each mL contains oestradiol dipropionate 1.3mg, 19-nortestosterone undecylenate (nandrolone undecenoate) 60mg, hydroxyprogesterone hexanoate 60mg
Actions: Depot anabolic steroid. Promotes maximum synthetis of amino acids, mineral and tissue proteins.
Presentation: 10mL vial

Probolin
Manufacturer: Jurox Pty Ltd
Composition: Nandrolone laurate 50mg/ml in arachis oil; benzyl alcohol 5% as preservative
Presentation: 10mL vial

Protabol
Manufacturer: Jurox Pty Ltd
Composition: Methandriol dipropionate 75mg/ml; oil base
Presentation: 10mL vial

Reepair
Manufacturer: Jurox Pty Ltd
Composition: Each mL contains propionyloestradriol 2mg, nandrolone undecylenate 30mg, hydroxyprogesterone hexanoate 80mg
Actions: Bone and tissue repair
Presentation: 10mL vial

Sovapoise Boldenone Anabolic
Manufacturer: Solvay Biosciences Pty Ltd
Composition: Boldenone undecenoate 50mg/ml
Actions: Long acting anabolic injection
Presentation: 50mg/ml: 50ml vial

Spectriol
Manufacturer: RWR Veterinary Products Pty Ltd
Composition: Each mL contains methandriol diproprionate 20mg, nandrolone phenylpropionate 15mg, testosterone enathate 10mg, testosterone hexahydrobenzoate 10mg, testosterone propionate 5mg testosterone cypionate 5mg, oily base
Actions: Combination of 6 steroid esters, which have slightly different rates of release from the injection site and varying anabolic/androgenic ratios.
Presentation: 10ml vial

Stanabolic
Manufacturer: Illium Veterinary Products
Composition: Stanozolol 50mg/ml
Presentation: 20ml vial

Stanazol
Manufacturer: RWR Veterinary Products Pty Ltd
Composition: Stanozolol 50mg/ml
Presentation: 20ml vial

Stanosus 50
Manufacturer: Jurox Pty Ltd
Composition: Stanozolol 50mg/ml in microfined aqueous suspension
Presentation: 20ml vial

Superbolin
Manufacturer: Advance Veterinary Products Pty Ltd
Composition: Methandriol diproprionate 75mg/ml in arachis oil
Presentation: 20 ml vial

The Australian Racing Board (ARB) introduced new rules banning the use of anabolic steroids from November 1, 2013 and enforceable from May 1, 2014.