SARMS versus Pro-Hormones and Pro Steroids

Submitted by patrickius on Wed, 2011-06-29 21:59

Which One Wins As The Best Alternative To Steroids?

When Pro-Hormones first hit the scene, anticipation was high. But it didn’t take long before it became obvious that these compounds were pretty weak in replicating the muscle building effects of real steroids. And to make matters worse, they carried most of the same negative side effects of steroids. That was not a winning combination. Over the years there were (supposed) improvements, one pretty much as bad as the next, until a new invention hit the market – the designer steroid. These didn’t act as precursors to anabolic and androgenic receptors, instead, they were actual steroids that have been manipulated in a way that they were able to get in under the wire of being classified as a controlled substance. They actually worked pretty well. And they were the best legal alternative to anabolic steroids to date. But times have changed.

Technically, Pro-hormones and pro-steroids are no longer allowed to be sold but it wouldn’t take much of a search to track some down. Many commercial health food stores still carry a copious line of pro-hormones and their collective imitators – all using various titles to manage staying commercially available. Unfortunately, these products have one major drawback. Not only are they as liver toxic as 17AA oral steroids, they’ve been shown to be kidney toxic as well. These risks should not be understated. Liver and kidney problems often go undetected until sever damage has been inflicted. Still, to many who did not want to go the route of dealing with the black market for steroids, they’re willing to take the risk since were the only choice. Until now.

The latest addition to non-steroidal muscle builders is SARMS but unlike Pro hormones or Pro steroids, they aren’t an imitation of steroids -- they’re an improvement. And they aren’t being promoted by amateur chemists and supplement companies. Some of the top scientists and pharmaceutical companies are working on getting this to the market. But it’s available NOW. (For research purposes).

SARMS (Selective Androgen Receptor Modulators ) are a unique class of androgen receptor molecules. The intent is to have the same effects as steroids but are much more “selective” in their action – similar to testosterone but without the negative side effects, most notably prostate enlargement and possible carcinoma. Another benefit is that no injection is required. It comes in a non-toxic oral form that has a half-life of between 2.6 and 5.3 hours(1). The goal is to allow the customized response of entering muscle tissue that are the target of the therapy which in return will respond as they would to testosterone. Other tissues where undesirable side effects (such as the prostate) are produced will not be affected(2). To add to the benefits a new class of sarms called "sarms S-4" has shown to have little to no effect on the hpta unlike pro hormones or designer steroids. This means no post cycle therapy is needed after a cycle of S-4 and potensaily life long complications are avoided(3). S-4 has also shown little to no ability to convert to estrogen so gyno "a common problem with pro hormones" is also avoided(4).

To many researchers, scientist, pharmacologists and just about anyone familiar with anabolic enhancement, this is obviously a huge leap in the area of anabolic/androgenic enhancement. Whereas pro-hormones were sort-of like steroids, in that they create a facsimile some of the effects, SARMS delivers steroid-like results in a big way. Comparing SARMS to pro-hormones is like comparing a 47” HD flat screen Television to a 12” black and white TV with tubes. There’s just no way one isn’t light years better than the other.(5) And everyone who has tried both would agree.

 

Pro-Hormones and Pro-Steroids are all based on a flawed principle – attempted to act similarly to steroids, yet avoid classification by altering some of the molecular structure. That’s the problem. Once you alter a molecule chain, it changes everything. And although some of the effects may remain, it’s essentially a fraudulent version of what you’re attempting to replicate. Pro hormones are actually discarded forms of steroids. The pharmaceutical companies deemed them so inferior they abandoned the technology. It was this same technology that was resurrected for no other reason other than to get a drug on the market that could be sold as a supplement. SARMS is the opposite. It isn’t an imitation. It’s the next stage(6). Because Pro Hormones and designer steroids are made to be "like steroids" or are in fact a steroid analog they pose the problem of making WADA tested athletes test positive for steroids when tested. Sarms S-4 however does no such thing and to this date there is no way to test for Sarms S-4 ether in a athletes blood or urine So a athlete can safely take S-4 without fear of testing hot for a wada banned substance.

SARMS.were developed for the same reasons as steroids – to prevent muscle wasting through increased nitrogen retention. The main difference is that instead of using the old technology on which all steroid are based, it incorporated state of the art discoveries. The results were astonishing – so much so that research has begun in the medical community in Europe and the results have been extremely positive. Those more adventurous individuals have already begun incorporating SARMS for muscle building purposes and Hormone Replacement. And it looks as if SARMS is here to stay.

SARMS produces what many consider “high quality” muscle. The gains are very solid, unlike the results from many pro-hormones that are mostly water weight. SARMS also has the added benefit of not being capable of aromatizing to estrogen(7).

It’s arguable that SARMS is actually superior to pharmaceutical grade steroids. 50-100 mg a day will yield a similar result to 25- 50mg of an oral steroid like turinabol, but without the toxicity. Be that as it may, it’s evident that a cycle of SARMS far superior to any pro-hormone or pro-steroid.

So there’s really no contest here. SARMS blows away any Pro-hormone or OTC Pro-steroid on the market. One cycle is all it‘ll take to convince you.

References.

  1. resorption in rats. AAPS Pharm Sci. 2003;5 Abstract R6167.
    9.Marhefka CA, Gao W, Chung K, Kim J, He Y, Yin D, Bohl C, Dalton JT, Miller DD. Design, synthesis, and biological characterization of metabolically stable selective androgen receptor modulators. Journal of Medicinal Chemistry. 2003
  2. Yin D, Gao W, Kearbey JD, Xu H, Chung K, He Y, Marhefka CA, Veverka KA, Miller DD, Dalton JT. Pharmacodynamics of selective androgen receptor modulators. Journal of Pharmacology and Experimental Therapeutics. 2003;304:1334–1340. [PubMed
  3. Endocrinology. 2005 Nov;146(11):4887-97. Epub 2005 Aug 11.
    Selective androgen receptor modulator treatment improves muscle strength and body composition and prevents bone loss in orchidectomized rats.
    Gao W, Reiser PJ, Coss CC, Phelps MA, Kearbey JD, Miller DD, Dalton JT.
    Division of Pharmaceutics, College of Pharmacy and Department of Oral Biology, The Ohio State University, 500 West 12th Avenue, L. M. Parks Hall, Room 242, Columbus, Ohio 43210, USA
  4. Pharmacokinetics of S-3-(4-acetylamino-phenoxy)-2-hydroxy-2-methyl-N-(4-nitro-3-trifluoromethyl-phenyl)-propionamide in rats, a non-steroidal selective androgen receptor modulator
    J. D. KEARBEY,† D. WU,† W. GAO,† D. D. MILLER,‡ and J. T. DALTON†*
    †Division of Pharmaceutics, College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA.
    ‡Department of Pharmaceutics, Graduate Health Sciences Center, College of Pharmacy, University of Tennessee, Memphis, TN 38163, USA
  5. Selective androgen receptor modulator treatment improves muscle strength and body composition and prevents bone loss in orchidectomized rats.
    Gao W, Reiser PJ, Coss CC, Phelps MA, Kearbey JD, Miller DD, Dalton JT.
    Division of Pharmaceutics, College of Pharmacy and Department of Oral Biology, The Ohio State University, 500 West 12th Avenue, L. M. Parks Hall, Room 242, Columbus, Ohio 43210, USA
  6. In vivo metabolism and final disposition of a novel nonsteroidal androgen in rats and dogs.
    Perera MA, Yin D, Wu D, Chan KK, Miller DD, Dalton J.
    Division of Pharmaceutics, College of Pharmacy, The Ohio State University, 500 West 12th Ave., Columbus, OH 43210, USA
  7. Pharmacokinetics of S-3-(4-acetylamino-phenoxy)-2-hydroxy-2-methyl-N-(4-nitro-3-trifluoromethyl-phenyl)-propionamide in rats, a non-steroidal selective androgen receptor modulator
    J. D. KEARBEY,† D. WU,† W. GAO,† D. D. MILLER,‡ and J. T. DALTON†*
    †Division of Pharmaceutics, College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA.
    ‡Department of Pharmaceutics, Graduate Health Sciences Center, College of Pharmacy, University of Tennessee, Memphis, TN 38163, USA.