Metribolone (methyltrienolone)

Metribolone is an oral steroid which is a derivative of the hormone trenbolone which has been C17 alpha alkylated so make it possible to be taken orally. This modification has created a steroid that is considerably stronger than the drug it is derived from. This drug was first developed in the 1960s and was used clinically in the 60s and 70s mainly for the treatment of advanced cases of breast cancer. Here, its exceedingly strong anabolic/androgenic action helps the drug counter the local effects of endogenous estrogens, lending it some efficacy for slowing or even regressing tumor growth. Such application didn’t last long however, as more realistic evaluations of the drug’s toxicity soon led to the end of its use in human medicine. By the 1970s, metribolone was becoming an accepted standard in non human research studies, especially those pertaining to the study of the androgen receptor activity. For this purpose the drug is very well suited. Its sheer potency and resistance to serum-binding proteins makes it an excellent in vitro receptor-binding standard to compare other agents to. These days, metribolone’s official use remains only for research purposes. However, some interest has gained in the black market and the drug is being seen in circulation now on the international scene.

Metribolone is one of the strongest anabolic steroids to ever be developed. Its potency has been measured at 120-300 times greater than that of methyltestosterone, with greater dissociation between anabolic and androgenic effects. Milligram for milligram, methyltrienolone is a more active steroid than any agent sold on the commercial market, requiring doses as little as .5 to 1 milligram per day to notice a strong anabolic effect. Its potency is only matched by its toxicity which has limited its modern medical use to that of a research agent only. The effects of this drug would be similar to those seen from the powerful hormone trenbolone. Users can expect a gain in solid muscle mass and dramatically increased strength. Because this substance doesn’t convert to estrogen, it would be of use to bodybuilders nearing contest. Although it isn’t converted to estrogen, it is important to note that metribolone does bind to the progesterone receptor which can lead to progesterone related side effects. These side effects can be similar to those seen from estrogen buildup and include things such as water and fat retention and even gyno, which is development of female like breast tissue under the nipples. This drug is also very androgenic and it’s not uncommon for the user to experience androgen related side effects. These side effects can include things such as oily skin, acne, and increased body and facial hair. In women excess androgen can cause masculizing side effects such as deepening of the voice, growth of facial hair, and clitoral enlargement. This drug is a C17aa and is one of the most toxic steroids there has ever been. Users are strongly urged to consider this and take the necessary precautions such as using a reasonable dose and limiting cycle length and also running an agent such as Liv-52 to help protect the liver from strain. The drug will also be very harsh on the user’s natural testosterone making a post cycle therapy protocol very necessary at the end of use. Users often choose to use substances such as clomid and HCG to restore natural testosterone function to normal after using anabolic steroids.

Male users typically use a dosage of .5-1mg per day of this drug. It is recommended that cycles be kept shorter than 4 weeks due to the high level of toxicity the substance displays. Women should not use this drug as it is far to androgenic.