Insulin use in the BB and risks new version
by SIBERIANTIGER
Times have copied the text into your post here with pictures because I am suffering constantly having to update the download link.
Enjoy reading the guide!
Insulin
Use in bodybuilding and risks
Revised version from 16.05.2009
Table of Contents:
---- Introduction ----
---- Disclaimer ----
First Introduction to the subject
1.1 Insulin - A little history on the introduction
1.2 Production
1.2.1 Industrial production past and present
1.2.2 Endogenous production
Second Relevant knowledge in the field of bodybuilding
2.1 Advantages
2.1.1 Improved cellular hydration
2.1.2 Increased cell volume
2.1.3 Larger glycogen
2.1.4 anti-catabolic effect
2.1.5 Anabolic effect
2.2 Disadvantages
2.2.1 Blood glucose lowering effect
2.2.2 Water Storage
2.2.3 Inhibition of fat loss, promote the fat body
2.2.4 lipohypertrophy
2.3 Different Insulins
2.3.1 Mixing insulins
2.3.2 Long-term insulin
2.3.3 depot insulins
2.3.4 Altinsuline
2.3.5 Ultra Short-acting insulins
2.4 All around the injection
2.4.1 Injection Materials
2.4.2 injection sites
2.4.3 Injection
2.5 Hazards
2.5.1 Hazard Prevention and Troubleshooting
2.5.2 What do others have to wenns is sometimes too late
Third Specific knowledge relating to nutrition, timing and planning
1.3 Nutrition - meaning
3.1.1 Carbohydrates
3.1.2 Proteins
3.1.3 Fats
3.2 Planning the meals before and after injection
3.2.1 KH-care, Phase I
3.2.2 KH-supply, phase II
3.2.3 EW-care, Phase I
3.2.4 EW-supply, phase II
3.2.5 Fats
3.2.6 Compliance with the optimal number of calories-
3.3 Supplements
4.3 Dosage, on / off patterns, duration of use
3.4.1 Dosage
3.4.2 On / Off schemas / duration of use
---- Conclusion ----
---- Introduction ----
I write this to clarify.
There are many myths, falsehoods and ignorance, and such a backlog in
Area "insulin use for BB" that I decided to finally shed some light
to bring into the darkness. This article is intended to be suitable not only for absolute beginners, and
The more advanced will be informed and perhaps even in this sector
something to learn.
For questions, please do not hesitate to worse if it can be prevented
can.
This article may like to be passed, but if it please the unamended
Original!
The read only as a preface, a lot of fun now.
---- Disclaimer ----
To the misuse of insulin serious, harmful and
life-threatening side effects can occur! Information may not be as a medical
Ratings are used and are not intended for the guidance of a drug abuse
suitable! Before an exogenous supply of insulin, they seek the advice of their doctor and get
be an agreement!
The author assumes no liability for damages Based on this information
! arise
First Introduction to the subject
1.1 Insulin - A little history on the introduction
From time immemorial (to 1922) was the disease diabetes mellitus as an incurable and cruel
considered and inevitably fatal disease.
Evidence can be found also in the ancient scriptures of India as on Egyptian
Hyrogliphen. One of the most striking descriptions of the ancient world comes from the 2nd
century AD the Greek physician Aretaeus the Cappadozier:
"Diabetes is a wonderful affection, not as common in men, a melting
Flesh and limbs in the urine [...] Life is short, disgusting and painful, the
Unquenchable thirst, death is inevitable. "
In order not to penetrate deeply into the topic of diabetes should be noted that in the short
Disease, diabetes mellitus, the beta cells in the pancreatic islet cells in the
Pancreas no or very little insulin can produce and
consequently, the blood sugar level rises [hereinafter for brevity: BZS] for a
KH-rich meal, far beyond what is healthy over the long run to what a highly
catabolic and is not life-threatening condition last.
The efforts from the medical point of view in this area have been popularized in 1922 by
a Canadian research team at the Physiological Institute of the University of Toronto. 1921 was
Canadian surgeon Frederick Grant Banting to Prof. JJR MacLeod, head of the
Physiological Institute, asking approached to give him the opportunity to
Blood glucose lowering using a pancreatic extract in diabetic patients
. explore Although MacLeod initially not very enthusiastic about this idea, he turned
Banting a small space available and just gave him the doctorate
Physiologist Charles Herbert Best as Assistant to the side. A short time later succeeded in
two researchers to establish a hydrochloric acid alcohol extract of the pancreas, with whom she
could treat an experimentally induced diabetes in dogs successfully.
As late as 1922 she made a self-experiment with a product they
Pancreatic extract. In 1922 the first man, a 13-year-old boy successfully treated.
His name was Leonard Thompson, he was 27 years old and died of a
Bronchopneumonia. With the help of an improved extract from the 1922 James Collip
was developed, was the second patient, Elizabeth Hughes, then 11 years old,
treated. They later married, got three children and died at the age of 73 years
Heart failure. 1923 Banting and Macleod received the Nobel Prize for Medicine was awarded to
they voluntarily shared with the Best and Collip.
To supplement a small table on the main events in the history of
Insulin and the treatment options:
1923 start of the insulin production in Europe: regular insulin sour beef
1946 NPH (neutral protamine Hagedorn) insulin: first long-acting insulin gewebsneutrales
1953 zinc-insulin with different long-acting
1982 First acting human insulin
1985 First Pen: Novo-Pen from NovoNordisk
1995 The first insulin syringe: NovoLet
1999 First Insulinreleaser for the treatment of type 2 diabetes: repaglinide
2000 First insulin analog: insulin aspart
Thus, the breakthrough was made and the future treatment of diabetes was
virtually nothing in the way initially from the cumbersome extraction of insulin
Pancreas of animals, later on by genetic engineering.
Read more in the next chapter.
1.2 Production
1.2.1 Industrial production past and present
After this breakthrough discovery, which saved many lives, began
you to gain insulin.
It started with this said pancreatic extracts from pigs and cattle.
However, since this had many disadvantages (possible disease transmission, other
Impurities, long procedure to gain only a limited amount of [a
Porcine pancreas delivers 300 IU]) is increased in the 70s on the biosynthetic
Production by using the bacterium Escherichia coli.
[For a better understanding of further explanation here is a small graphic
added:]
The goal was the molecule (consisting of 51 amino acids by sulfur bridges
there are connected) to synthesize.
The A chain consists of 21 amino acids, the B-chain from 30th
In microorganisms, (originally the aforementioned Escherichia coli) is a ring
closed stretch of DNA, called plasmid used, which forces them, one for
they create completely useless protein.
The original method for the biotechnological production of insulin was about
to produce two separate strains of the A chain and B chain and then the chemically
to each other.
But this kind of production is risky and is more difficult than today
method used. She has the disadvantage in that the bacterium that it produces
Product in the cell body reserves. The bacteria have to more or less toxic by
Substances dissolved and the resulting mixture of proteins and glycoproteins
be carefully cleaned up.
Therefore, the drug companies have decided not to Escherichia coli
to produce, but with brewer's yeast or baker's yeast. Yeasts have the advantage of their
Deliver product into the culture medium. The first stage of production is no longer so, the
Lysis of the microorganisms, but their removal by filtration. Can from the supernatant of the
Insulin by known chromatographic (HPLC) methods are relatively isolated simply
be.
In addition it should be said here that the fungus an artificial plasmid is used, which
these forces to produce a proinsulin related to the "precursor". The A-and B-chain
are already linked by disulfide bridges and are still hanging with four amino acids
together, which are later cleaved enzymatically. The complex connection of Aand
B-chain is abolished
by SIBERIANTIGER
Times have copied the text into your post here with pictures because I am suffering constantly having to update the download link.
Enjoy reading the guide!
Insulin
Use in bodybuilding and risks
Revised version from 16.05.2009
Table of Contents:
---- Introduction ----
---- Disclaimer ----
First Introduction to the subject
1.1 Insulin - A little history on the introduction
1.2 Production
1.2.1 Industrial production past and present
1.2.2 Endogenous production
Second Relevant knowledge in the field of bodybuilding
2.1 Advantages
2.1.1 Improved cellular hydration
2.1.2 Increased cell volume
2.1.3 Larger glycogen
2.1.4 anti-catabolic effect
2.1.5 Anabolic effect
2.2 Disadvantages
2.2.1 Blood glucose lowering effect
2.2.2 Water Storage
2.2.3 Inhibition of fat loss, promote the fat body
2.2.4 lipohypertrophy
2.3 Different Insulins
2.3.1 Mixing insulins
2.3.2 Long-term insulin
2.3.3 depot insulins
2.3.4 Altinsuline
2.3.5 Ultra Short-acting insulins
2.4 All around the injection
2.4.1 Injection Materials
2.4.2 injection sites
2.4.3 Injection
2.5 Hazards
2.5.1 Hazard Prevention and Troubleshooting
2.5.2 What do others have to wenns is sometimes too late
Third Specific knowledge relating to nutrition, timing and planning
1.3 Nutrition - meaning
3.1.1 Carbohydrates
3.1.2 Proteins
3.1.3 Fats
3.2 Planning the meals before and after injection
3.2.1 KH-care, Phase I
3.2.2 KH-supply, phase II
3.2.3 EW-care, Phase I
3.2.4 EW-supply, phase II
3.2.5 Fats
3.2.6 Compliance with the optimal number of calories-
3.3 Supplements
4.3 Dosage, on / off patterns, duration of use
3.4.1 Dosage
3.4.2 On / Off schemas / duration of use
---- Conclusion ----
---- Introduction ----
I write this to clarify.
There are many myths, falsehoods and ignorance, and such a backlog in
Area "insulin use for BB" that I decided to finally shed some light
to bring into the darkness. This article is intended to be suitable not only for absolute beginners, and
The more advanced will be informed and perhaps even in this sector
something to learn.
For questions, please do not hesitate to worse if it can be prevented
can.
This article may like to be passed, but if it please the unamended
Original!
The read only as a preface, a lot of fun now.
---- Disclaimer ----
To the misuse of insulin serious, harmful and
life-threatening side effects can occur! Information may not be as a medical
Ratings are used and are not intended for the guidance of a drug abuse
suitable! Before an exogenous supply of insulin, they seek the advice of their doctor and get
be an agreement!
The author assumes no liability for damages Based on this information
! arise
First Introduction to the subject
1.1 Insulin - A little history on the introduction
From time immemorial (to 1922) was the disease diabetes mellitus as an incurable and cruel
considered and inevitably fatal disease.
Evidence can be found also in the ancient scriptures of India as on Egyptian
Hyrogliphen. One of the most striking descriptions of the ancient world comes from the 2nd
century AD the Greek physician Aretaeus the Cappadozier:
"Diabetes is a wonderful affection, not as common in men, a melting
Flesh and limbs in the urine [...] Life is short, disgusting and painful, the
Unquenchable thirst, death is inevitable. "
In order not to penetrate deeply into the topic of diabetes should be noted that in the short
Disease, diabetes mellitus, the beta cells in the pancreatic islet cells in the
Pancreas no or very little insulin can produce and
consequently, the blood sugar level rises [hereinafter for brevity: BZS] for a
KH-rich meal, far beyond what is healthy over the long run to what a highly
catabolic and is not life-threatening condition last.
The efforts from the medical point of view in this area have been popularized in 1922 by
a Canadian research team at the Physiological Institute of the University of Toronto. 1921 was
Canadian surgeon Frederick Grant Banting to Prof. JJR MacLeod, head of the
Physiological Institute, asking approached to give him the opportunity to
Blood glucose lowering using a pancreatic extract in diabetic patients
. explore Although MacLeod initially not very enthusiastic about this idea, he turned
Banting a small space available and just gave him the doctorate
Physiologist Charles Herbert Best as Assistant to the side. A short time later succeeded in
two researchers to establish a hydrochloric acid alcohol extract of the pancreas, with whom she
could treat an experimentally induced diabetes in dogs successfully.
As late as 1922 she made a self-experiment with a product they
Pancreatic extract. In 1922 the first man, a 13-year-old boy successfully treated.
His name was Leonard Thompson, he was 27 years old and died of a
Bronchopneumonia. With the help of an improved extract from the 1922 James Collip
was developed, was the second patient, Elizabeth Hughes, then 11 years old,
treated. They later married, got three children and died at the age of 73 years
Heart failure. 1923 Banting and Macleod received the Nobel Prize for Medicine was awarded to
they voluntarily shared with the Best and Collip.
To supplement a small table on the main events in the history of
Insulin and the treatment options:
1923 start of the insulin production in Europe: regular insulin sour beef
1946 NPH (neutral protamine Hagedorn) insulin: first long-acting insulin gewebsneutrales
1953 zinc-insulin with different long-acting
1982 First acting human insulin
1985 First Pen: Novo-Pen from NovoNordisk
1995 The first insulin syringe: NovoLet
1999 First Insulinreleaser for the treatment of type 2 diabetes: repaglinide
2000 First insulin analog: insulin aspart
Thus, the breakthrough was made and the future treatment of diabetes was
virtually nothing in the way initially from the cumbersome extraction of insulin
Pancreas of animals, later on by genetic engineering.
Read more in the next chapter.
1.2 Production
1.2.1 Industrial production past and present
After this breakthrough discovery, which saved many lives, began
you to gain insulin.
It started with this said pancreatic extracts from pigs and cattle.
However, since this had many disadvantages (possible disease transmission, other
Impurities, long procedure to gain only a limited amount of [a
Porcine pancreas delivers 300 IU]) is increased in the 70s on the biosynthetic
Production by using the bacterium Escherichia coli.
[For a better understanding of further explanation here is a small graphic
added:]
The goal was the molecule (consisting of 51 amino acids by sulfur bridges
there are connected) to synthesize.
The A chain consists of 21 amino acids, the B-chain from 30th
In microorganisms, (originally the aforementioned Escherichia coli) is a ring
closed stretch of DNA, called plasmid used, which forces them, one for
they create completely useless protein.
The original method for the biotechnological production of insulin was about
to produce two separate strains of the A chain and B chain and then the chemically
to each other.
But this kind of production is risky and is more difficult than today
method used. She has the disadvantage in that the bacterium that it produces
Product in the cell body reserves. The bacteria have to more or less toxic by
Substances dissolved and the resulting mixture of proteins and glycoproteins
be carefully cleaned up.
Therefore, the drug companies have decided not to Escherichia coli
to produce, but with brewer's yeast or baker's yeast. Yeasts have the advantage of their
Deliver product into the culture medium. The first stage of production is no longer so, the
Lysis of the microorganisms, but their removal by filtration. Can from the supernatant of the
Insulin by known chromatographic (HPLC) methods are relatively isolated simply
be.
In addition it should be said here that the fungus an artificial plasmid is used, which
these forces to produce a proinsulin related to the "precursor". The A-and B-chain
are already linked by disulfide bridges and are still hanging with four amino acids
together, which are later cleaved enzymatically. The complex connection of Aand
B-chain is abolished
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