Carbs and hgh timing

[Bigs251 Senior Member Find all posts View Profile Close Bigs251]

I've been reading online and can't get a straight answer. Is it best to take hgh with no carbs in your stomach and then eat them 30mins to an hour later? Or should you take your hgh shot and then consume a meal with carbs?

[ODB Senior Member Find all posts View Profile Close ODB]

no need to worry about empty stomach with exo GH;

GH is active straight away. GH-receptor expression will be increased immediately and the insulin is not high enough and chronic enough to effect GH-receptor translocation (i.e. movement to the cell surface). Insulin does however aid the synthesis of GH-Receptors.

GH will instigate synthesis of IGF-1 but this is not a one off. IGF-1 should already be elevated from continued GH use. Its like keeping an inflated balloon in the air by pushing it up every time if falls down to shoulder level. Each GH dose is like swating IGF-1 back up. As long as you dose GH regularly IGF-1 won't (like the balloon) hit the floor. So IMHO forum-logic concerning GH timing & IGF-1 creation is flawed.

Food won't interfere with GH's actions of binding to a receptor and mediating growth events such as IGF-1 synthesis in the liver & synthesis in muscle. But even if for some reason it were by the time you get the meal made and ingested the GH will have already binded to the receptors and initiated the first wave of events.

Growth Hormone has positive effects on protein metabolism. For a full explanation please see: Protein Metabolism - How various hormones create anabolism

Ideally you want to have protein in your system so the amino acids can contribute toward anabolism as the substrate and Growth Hormone (GH) can assist. GH in short increases Branch Chain Amino Acid (BCAA) transport and other aminos and reduces the oxidation of amino acids such as Leucine at the same time increasing whole body protein synthesis. So you want GH to be active in your system when protein is present because GH can do positive things with protein. If there are no amino acids (from ingested protein) to transport into muscle then GH can not contribute toward anabolism in that regard.

The GH pulse created by administration of GHRH/GHRP (Growth Hormone Releasing Hormone/Peptides) begins to rise within 5 minutes and peaks at the 30 to 35 minute marks before slowly decreasing. You want the protein to be available to your body during the peak of the GH pulse and when GH is most active.

So you must begin to eat protein at least well in advance of the GH pulse peak.

Protein for the most part does not interfere w/ GH release. Carbohydrates blunt GHRH's action but have only a smaller partial effect on GHRP's action. Fats have the strongest blunting effect on both GHRH and GHRP's action.

External GHRH and GHRPs bind to their respective receptors within 10 to 15 minutes. What GHRH & GHRP that hasn't will at least be present in the pituitary awaiting newly available receptors. So after 15 minutes it is not very likely that circulating carbohydrates and fats will have a significant effect.

Ideally IF GH pulsation was the only goal you would wait 30 minutes to eat. But it isn't. Anabolism is the goal and since that requires protein and the presence of GH you must choose a happy medium. Fifteen minutes is plenty of time to wait.

Summary

- Eat protein whenever you want early on and wait 25 minutes to eat fats and carbs. OR

- Compromise a little and eat a mixed meal of mostly protein and carbs w/ very little fat 15 minutes after GHRH/GHRP administration. Wait the full 30 minutes to take in any genuine fats.

if u wish to research more;

Insulin Regulation of Human Hepatic Growth Hormone Receptors: Divergent Effects on Biosynthesis and Surface Translocation, Kin-Chuen Leung, Nathan Doyle, Mercedes Ballesteros, Michael J. Waters, And Ken K. Y. Ho, The Journal of Clinical Endocrinology & Metabolism 2000 Vol. 85 No. 12 4712-4720

[Bigs251 Senior Member Find all posts View Profile Close Bigs251]

Ah nice article! Thank you!

[cherylmm7 Junior Member Find all posts View Profile Close cherylmm7]

Great article, super informative. Thanks

[AndyBB Junior Member Find all posts View Profile Close AndyBB]

thank you for article