Peptides - HGH+GHRP6, etc

[ODB Senior Member Find all posts View Profile Close ODB]

(This thread is a continuation of an interesting discussion that started in Stumpy's thread GHRP6.)

Open for discussing + Broscience + speculation on Peptides and Peptides used with HGH.

Thanks Sam. I'm thinking of taking ghrp-6 with cjc-1295 w/o DAC 3x100mcg a day. And want too take 8iu's of Hygetropin. But not sure yet how to spread it on the day.

I have been reading alot about peptides + GH lately + their seems to be good data/feedback from using a pulsing method w/GH = taking GH thru out the day in various doses with days off. for example taking GH EOD. - although the multiple inj per day is not as significant, depending on dosing as taking breaks.
It seems every 16hrs of synthetic GH use benefits from 24 hours off. (long medical study/article - animal - about Ghrelling,Insulin,IGF, etc)
Their also seems to be a synergistic connection between GHRP6 +GH -according to what I read your 1st inj of GH tricks the body + works, then the second inj is less effective unless u take inj of GHRP6 10-15mins B4, or take GHRP6 on off days.

GHRP6 also seems to have a saturation point of about 100mcg (every 3 - 4 hrs)actually goes by weight but good rule of thumb.

[ODB Senior Member Find all posts View Profile Close ODB]

One definition of CJC-1295;

So what is CJC-1295 and what does it have to do with myostatin you ask... CJC-1295 is a long acting synthetic version of Growth Hormone Releasing Hormone (GHRH). 30mcg/kg to 60mcg/kg doses can increase gh levels up to 10X normal for 6 days or more with plasma IGF-1 concentrations by 3X for 9-11 days. The estimated 1/2 life is 5.8-8.1 days. After multiple doses the mean IGF-1 levels remain above base level for up to 28 days. Results show that 30mcg/kg CJC-1295 is equal to 5iu's of gh without the normal negative side effects from taking gh.

So how does CJC-1295 and Myostatin relate. Growth hormone directly regulates myostatin. As growth hormone rises, myostatin lowers, which unleashes your potential for muscle growth. As myostatin lowers glucocorticoids effect on fat storage and muscle breakdown lowers. CJC-1295 raises gh levels which will lower myostatin which in turn will lower the effects of glucocorticoids fat storage and muscle breakdown.

[ODB Senior Member Find all posts View Profile Close ODB]

more reading - WTF;

Complete step-by-step guide for a peptide beginner

This is my first post and hope that it can benefit others that are in the exact same situation as me. This forum is brilliant and has a diverse range of very smart people who contribute to help one another. Thank you Dat for starting up, what I believe, to be the best, most informative, and scientifically backed researched forum on the topic of peptides and other substances.

After countless days and endless hours of reading through the threads, I have decided to create a thorough thread that will incorporate all the information required in basic form to get a peptide virgin user up and going from the start. This should alleviate the pain of searching the thousands of threads and posts for information. This is primarily for people wanting to add a bit of lean mass, reduce fat mass, and improve quality of life.

Please correct me if I am wrong anywhere along the lines of my following methods as I too, am still a very new user and still in the beginner's learning phase. I want to outline the basics without getting involved in CPWO methods, insulin, L-carnitine, MTII, synthetic growth hormones, anabolic steroids, and all the other supplemental substances to aid in one's achievements. I want to keep this non scientific and basic without it becoming too daunting for new people to understand.

From the start:
1 - You are on this site because you have heard of and want to become more familiar with Growth Hormone Releasing Peptide (GHRP) and/or Growth Hormone Releasing Hormone (GHRH). These 2 materials administered can give you an increased quality of life in ways of anti-aging, muscular hypertrophy, fat loss, injury repair, higher bone density, and better sleep.
2 - GHRP can be used on its own to increase our natural Growth Hormone (GH) pulse release from the Pituitary Gland in the brain. GHRP dosed in conjunction with GHRH will amplify our growth hormone release significantly to gain maximal benefit.
3 - There are various types of GHRH's. The only GHRH to consider is tetra-substituted CJC-1295 / CJC-1295(without DAC) / modGRF(1-29). They are all the same thing but with a different name. They come in vials ranging in material weights measured in milligrams (mg) consisting of a solid freeze-dried (lyophilized) substance.
4 - There are various types of GHRP's. GHRP-6, GHRP-2, Hexarelin, and Imaporelin. The differences between them are potency and side effects. GHRP-6 is very potent and makes you quite hungry. GHRP-2 is potent and can slightly affect your sleep somewhat. Hexarelin is very potent but you can desensitize from higher dosages. Imaporelin is potent with the minimalist side effects of all 4 GHRP's.
5 - Peptides are dosed via a regular 1mL needle syringe typical to what a diabetic would use. It is administered Subcutaneously (SubQ) (just under the skin into the fat tissue), most usually around the abdomen region.
6 - The required amount (saturation dose) is 1mcg (microgram) per Kg (Kilogram) of bodyweight. The typical usage and for ease of measuring is 100mcg of modGRF(1-29) and/or 100mcg of your choice of GHRP. Lower dosages will simply result in less GH release due to a slightly weaker GH pulse and reduce any side effects you may have. A higher dose will have minimal benefit and is more a waste of money than anything else. But, in saying that, the more frequently dosed in any given day would result in more frequent pulses.
7 - Mixing (reconstitution) the lyophilized product in their vials with Bacteriostatic Water (BW) can take some getting used to. The idea is not to add too much dilution. Typical rule of thumb is to add 0.5mL of BW to 1mg of Peptide. So a 2mg vial should reconstitute with 1mL BW. 5mg with 2.5mL, 10mg with 5mL, etc. Squirt the BW along the inside wall of the vial in a smooth controlled manner being cautious not to agitate the mixture too much. It will dissolve itself and become clear. You can roll the vial gently between your fingers or hands but don't shake it to dissolve. The reconstitute is ok to be drawn once fully dissolved.
8 - On a 1mL needle, there are either 50 tick marks from 0-100, skipping every odd number OR 100 international units (IU). A 100mcg dose is half way between the 2nd and 3rd tick mark, OR 5 IU's (if you followed the above reconstitution). There are no half tick marks. It is OK to draw modGRF and GHRP into the one needle for a single shot. It is NOT OK to mix peptides in the same vial or syringe for storage.
9 - Reconstituted peptide should be stored in the refrigerator to prevent degradation. Left at room temperature, peptide will degrade within days but kept in the fridge will last months. You can pre-load syringes and store in freezer if you want but it is more of a hassle than being worth the effort.
10 - Doses can be taken throughout the day but at no less than 3 hour intervals between doses. 1 dose a day is typical for light injury repair, anti-aging effects, deeper sleep, and better quality of life. The most beneficial would be to dose immediately prior to going to bed for your daily sleep period. Sleep is the time when our pituitary is most active. 2 or 3 doses per day will give the added benefit of lean tissue build, and fat loss, considering your diet consists of good quality foods.
11 - Doses should be taken on empty stomach to benefit the most. This is usually 3 hours or more.
12 - Do not consume food for between 15-30 minutes after your dosage. Best time is around 20-25 minute mark. GH pulses should peak within about 10 minutes after dosage. Fats and Carbohydrates affect the pulse dramatically. Protein has no effect on pulse and you can have a pure protein source in your stomach at anytime if you so choose to.
13 - Dosage timing can be beneficial to your goals. For muscle growth, the 2nd most beneficial time to dose is post workout (PWO). Best time is pre-bed because sleep is when we recover and our cells repair and grow. Within 30 minutes should be fine but sooner the better. Remember to have your meal 20-25 minutes after dose.
14 - For fat loss, your supplemental dose is 1 hour pre-cardio exercise after a long fasting without food. Best time is after waking up and before breakfast. During cardio exercise, maintain a moderate intensity for between 30-60 minutes. 45 minutes is a good session. You do not want to go too hard or too long. A moderate pace will utilize Free Fatty Acids (FFA) at the highest rate for energy. Refrain from eating for approximately 2 hours after your exercise because this is the time the body is still burning fat as fuel. You must eat throughout the day to reduce the chance of muscle catabolism (breakdown).
15 - These Peptides can be used on a daily basis for the rest of your life without any harm. Enjoy!!!

[ODB Senior Member Find all posts View Profile Close ODB]

this is prob why GHRP 6 makes U lethargic ; Structurally GHRP-6 is composed of the amino acids L-Histidine, D-Tryptophan, L- Alanine, L- Tryptophan, D- Phenylalanine and L- Lysine

[Liquid Senior Member Find all posts View Profile Close Liquid]

GHRP 2 or 6 is great with MOD GRF 100mcg 3x daily. Add in some GH with AAS and you are set.

[Dutch Tank Junior Member Find all posts View Profile Close Dutch Tank]

GHRP 2 or 6 is great with MOD GRF 100mcg 3x daily. Add in some GH with AAS and you are set.

Yeah but how to do the injections? Say GHRP+CJC 3 times a day. But when too inject the GH?

[BigTex Junior Member Find all posts View Profile Close BigTex]

Yeah but how to do the injections? Say GHRP+CJC 3 times a day. But when too inject the GH?

SubQ injections......at 3/d go 1) 2 minutes before breakfast or just after you wake up. 2) as soo as you can after you train, 3) 30 minutes before bed time. All should be on an empty stomach ad try to get some protein in about 15 minutes after the injection. GH, at about the same time as your PM peptide dose.

[~BG~ Senior Member Find all posts View Profile Close ~BG~]

SubQ injections......at 3/d go 1) 2 minutes before breakfast or just after you wake up. 2) as soo as you can after you train, 3) 30 minutes before bed time. All should be on an empty stomach ad try to get some protein in about 15 minutes after the injection. GH, at about the same time as your PM peptide dose.

I agree except for the sub-q injections. It proven that obsorption is much slower sub-q the IM. IM injects are a must when it comes to timing your peptides.

[BigTex Junior Member Find all posts View Profile Close BigTex]

I agree except for the sub-q injections. It proven that obsorption is much slower sub-q the IM. IM injects are a must when it comes to timing your peptides.

After 4+ years using peptides I have never had a problem with absorption. I feel the effects of these within minutes of the injection. Plus, when you are to inject 2-3 times a day, I honestly think you are going to get very tired of IM injections that many times a day. If not, then more power to you!

[xamo Senior Member Find all posts View Profile Close xamo]

what terms

[ODB Senior Member Find all posts View Profile Close ODB]

Yeah but how to do the injections? Say GHRP+CJC 3 times a day. But when too inject the GH?

Dutch i do my GH 1st then GHRP6 15 min later. 3-5x a day - on workout days.
yes, IM inj is the best method but I agree w/BigTex i cannot do that many IM injects -plus pinning 3x a week AAS.

[BigTex Junior Member Find all posts View Profile Close BigTex]

I agree w/BigTex i cannot do that many IM injects -plus pinning 3x a week AAS.

ODB, we actually had this discussion on DAT's a while back. DAT provided a long explanation about the difference between subq, IM and IV use of peptides and GH. It can all be summed up in the following statement, "the GH release curves start at about the same time no matter whether administration is Subcutaneous, intra-muscular or intravenous." So we have to "pick our poison" so to speak. Myself, after 2-3 IM injections of anabolics each week I am about tired of IM injections. The sub-q thing is much easier to deal with, with all things being equal.

[ODB Senior Member Find all posts View Profile Close ODB]

great resource for peps info