Nandrolone Phenylpropionate

[JayDiesel Senior Member Find all posts View Profile Close JayDiesel]

GP Phenyl 100 by Geneza Pharmaceuticals is an injectable steroid containing 100mgs per ML of the hormone nandrolone phenylpropionate.

Unlike its relative, Nandrolone Decanoate, the ester of this nandrolone makes it very fast acting and therefore makes it possible for the compound to be out of the body much more quickly. This makes this steroid a better choice than Deca for tested Bodybuilders and athletes. Users typically follow a dosage schedule of every other day when using this substance to keep blood levels elevated and stable.

Durabolin, as it is often called, is one of the most popular steroids being used amongst bodybuilders today. Durabolin is a low androgenic steroid with high anabolic effect. It will aromatize in high dosages, but not at the rate of testosterone. Progesterone buildup is one side effect that some have trouble with although users report that the problem isn't as bad with this ester as it is with Deca. Users sensitive to these issues might choose to add Cabaser or Dostinex to their cycle.

This steroid can be used for cutting or for bulking. Bodybuilders often stack it with Testosterone for one of the most common and effective bulking cycles. The durabolin / winstrol stack is also very popular. It is believed that Winstrol helps block the progesterone buildup while the durabolin heIps with the joint issues that some suffer while on Winstrol. The joint relief and healing that durabolin provides is one of the main reasons it has become a very popular steroid with Bodybuilders. Androgen side effects are typically not an issue with GP Phenyl 100 as long as doses are kept within reasonable range.

Bodybuilders using this substance by itself sometimes report a loss of libido, therefore, it is recommended that one run at least a small dose of testosterone or even a high androgen like Proviron to help prevent this issue.

Women bodybuilders are also fond of this substance, where it's mild androgenic nature makes it a safe steroid for them to use without fear of masculizing side effects. Durabolin will shut down one's body's ability to make it's on natural testosterone, therefore a proper PCT program is recommended following a cycle of this substance.

Male bodybuilders often use Durabolin in doses of 400-600mgs a week for 8-12 weeks, while women find a dosage range of 50-100mgs weekly to be sufficient for seeing desired results.

[JayDiesel Senior Member Find all posts View Profile Close JayDiesel]

Nandrolone is a modification of testosterone (carbon atom removed from the 19th position) With an Anabolic/Androgenic ratio: 125:37, meaning it is highly anabolic (muscle building) and moderately androgenic (male characteristics). Due to nandrolones chemical structure it only aromatizes (converts to estrogen) slightly, at about 20% the rate of testosterone when it interacts with the aromatase enzyme. Ergo, estrogenic effects are not a major concern with its use. Of note, however, is that nandrolone is a progestin with a binding affinity of 20% to the progesterone receptor (15) (PgR), so side effects are still possible, though rare. The development of breast tissue in males (gynecomastia) has been reported in some steroid.com users. One of the most popular anabolic steroid used in bodybuilding cycles, nandrolone is also (medically) used to treat severe debility or disease states and refractory anemias.(1) It promotes tissue building processes, reverses catabolism (muscle destruction) and stimulates erythropoiesis (red blood cell production). This makes it a very useful drug to treat wasting disorders such as advanced H.I.V. (2)( 16), and also, makes it highly sought after by bodybuilders and athletes.
Nandrolone Decanoate, Cypionate, Laurate Cycles

Nandrolone is most commonly found with a cypionate, laurate, decanoate or plenylpropionate ester. Briefly explained, the ester determines how much of the given hormone is released over a period of time. Longer esters such as decanoate peak slowly and can keep stable blood plasma levels up to ten days, shorter esters such as the phenylpropionate peak more rapidly but the half-live is shorter. Shorter esters usually release much more active hormone per mg than longer esters, and of course, allow the drug?s effects to leave your system more quickly.. Surprisingly NPP (Durabolin) and ND (Deca) release almost the same amount of active nandrolone per 100mgs: 69% and 65% respectively; this does not correlate exactly though because blood levels of nandrolone are much higher (about doubled) post NPP usage compared to the same 100mg dose of ND. (see chart) NPP also has more distinct advantages over ND. One of the most common complaints about adding ND (Deca) to a cycle is the water retention that accompanies its use. (3) Gains from NPP are reported to be "clean" with minimal water retention and fat gain. While ND is usually used in "bulking" cycles, NPP is used in "cutting" cycles although either drug can be used in either regard. Being an oil based anabolic it is injected intramuscularly (into the muscle), many users inject it ED or EOD, however NPP can administered E4D without problems.

NPP, and nandrolone in general, has a number of benefits for athletes; it increases levels of serotonergic amines in the brain, these chemicals contribute to aggressive behavior, this could help athletes to train harder and improve speed and power.4 Nandrolone also increases levels of IGF-1 in muscle tissues.(5) This may be another way that makes nandrolone highly anabolic. NPP also benefits the athlete by increasing the number of androgen receptors (AR) one study showed that nandrolone given to rats at a dosage of 6mg/kg of bodyweight combined with muscle functional overload (muscle functional overload gives a similar effect to resistance training) had a 1,300% (!) increase in AR protein concentrations. (6) There is a direct link to muscle growth and AR levels. NPP also seems to be a promising fat loss agent, men given the drug had reduced levels of subcutaneous (under skin) adipose(fat) tissue, visceral (gut) fat loss was not as good however.(7) The fat loss effect seems though to be dose dependant, in one study NPP at a daily dose of 1, 4, or 10mg per kg of bodyweight the 10mg dose had the greatest effect on fatloss, thus displaying a dose respondant curve with NPP(8). The more you use, the more results you?ll get, with regards to this drug.

NPP is used to treat anemia by stimulating red blood cell production,(1) and an increase in RBC count can improve endurance during exercise via better lactic acid clearing and oxygen delivery. The blood is also better enabled to carry nutrients to muscle tissue to aid in repair, administration also increases the rate of muscle glycogen repletion after exercise helping the athlete dramatically improve recovery after strenuous physical exercise.(9) Athletes who require a high level of endurance in their chosen sport can benefit from the use of NPP.(15) A favorite with bodybuilders who suffer with sore joints, NPP can also improve collagen synthesis (10), which may improve joint function and alleviate joint pains. Many members of steroid.com swear by nandrolones ability to allow them to train in comfort.

NPP can be highly useful in either "bulking" or "cutting" cycles, and it would seem that diet and dosages are the determining factors of whether a cycle with this drug will be one or the other. Due to its highly anabolic nature coupled with low androgenic properties it can be incorporated into a mass cycle, usually stacked with testosterone and a powerful oral like possibly oxymetholone (Anadrol) or methandrostenolone (Dianabol). NPP can thus be part of a classic bulking cycle. For a cutting cycle NPP is usually be combined with other short-estered injectable anabolic steroids (testosterone propionate and boldenone acetate come to mind as likely choices) and one of the DHT derived orals such as stanozolol (winstrol) or oxandrolone (Anavar). NPP is said to produce good mass and strength gains in both cutting and bulking cycle phases (3). When one is planning a cutting cycle one must take caution if combining the 19-nor-testosterone derivative trenbolone with nandrolone. Trenbolone Acetate, although a powerful drug for lean muscle gains, strength, and fat loss is also a strong progestin with a binding affinity to the PgR of 60% (3x that of nandrolone). The elevated prolactin, can worsen HPTA insult, often causing the user to spend more money on preventative measures, the combo may also result in a difficult PCT protocol to regain natural testosterone production. So far few steroid.com members have any first- hand experience with NPP... limited to the few who know which UGLabs sells this particular form of nandrolone. This increases the popularity of "home brewing" ...since the powder comes out of China at very affordable prices. It is only a matter of time before NPP (or Durabolin) takes a special place in the arsenal of steroid.com members in their quest for more muscle.

Nandrolone Base + Phenylpropionate Ester
Molecular Weight(base):274.4022
Molecular Weight (ester): 150.174
Formula (base): C18 H26 O2
Formula (ester): C9 H10 O2
Melting Point (base): 122-124?C
Melting Point (ester): 20?C
Manufacturer: Organon
Effective Dose (Men): 200-600mgs/week (2mg/lb of Bodyweight)
Effective Dose (Women): 50-100mgs/week
Active life: 5 days
Detection Time: Up to 12 months
Androgenic/Aabolic ratio: 37:125

References:

1. Nursing2003 drug handbook.
2. Am J Physiol Endocrinol Metab. 2002 Dec; 283(6):E1214-22.
3. Steriod.com/steroid forums.
4. Med Sci Sports Exerc. 2003 Jan; 35(1):32-8.
5. Am J Physiol Endocrinol Metab. 2002 Feb; 282(2):E483-90
6. J Appl. Physiol.94 1153-61 2003
7. Int J Obes Relat Metab Disord. 1995 Sep; 19(9):614-24.
8. Ann Nutr Metab. 1991; 35(3):141-7.
9. J Vet Med A Physiol Pathol Clin Med. 2001 Aug; 48(6):343-52
10. Metabolism. 1990 Nov; 39(11):1167-9.)
11. Pharmacol Biochem Behav. 1988 Mar; 29(3):489-93.
12. Cancer Res. 2003 Oct 1; 63(19):6523-31.)
13. Expert Opin Pharmacother. 2004 Dec; 5(12):2549-58.
14. Cancer Res 1978 Nov; 38(11 Pt 2):4186-98
15. Med Sci Sports Exerc. 1995 Oct;27(10):1385-9.
16. Am J Physiol Endocrinol Metab. 2002 Dec;283(6):E1214-22. Epub 2002 Aug 27.

[JayDiesel Senior Member Find all posts View Profile Close JayDiesel]

Nandrolone Phenylpropionate, also known as “NPP” is very similar to the very popular steroid “Deca” which is Nandrolone with a longer ester (Decanoate). Nandrolone Phenylpropionate is, therefore, a shorter acting “Deca” for all practical intents and purposes. Anecdotally, it seems to produce less water retention than its longer acting cousin, and this would be very consistent with injectable testosterones, where we find that shorter esters provide much less water retention.

It’s a progestin, like any Nandrolone derivative, and is made by removing the carbon atom at the 19th position of the Steran Nucleus of testosterone. However, although it’s a progestin, Nandrolone (regardless of ester) doesn’t produce much of what we could properly call estrogenic side effects. Any side effects from Nandrolone Phenylpropionate would therefore more properly be termed progestenic in nature- as it only converts to estrogen at roughly 20% the rate of testosterone.

Regardless of ester, and water retention not withstanding, we find that all of the characteristics of found in one type of Nandrolone are found in any other. Nandrolone, probably owing to its progestenic nature has the ability to improve collagen synthesis (1) as well as bone mineral content (2). Clearly this would be a huge benefit to athletes with connective tissue problems or other joint issues, although drug-tested athletes need to avoid Nandrolones because of their detectability in urine for a year to eighteen months after administration. Also, since it is progestin (with slight estrogenic ability), it probably has some very beneficial effects on the immune mediated anti-inflammatory process, thereby soothing joints as well as helping to heal them.

Nandrolone is one of the few steroids which has been used successfully in AIDS patients to stimulate weight gain (3), and although athletes using NPP in lieu of Deca find it to produce slightly less weight gain, this is probably a result of gaining less water weight. Nandrolone Phenylpropionate, is a more popular drug than Deca for use in cutting cycles recently, due to this fact.

This brings up the fact that although Deca has a very long active life, NPP has a much shorter one, and this means that people are forced to inject at least two times per week, with the more common protocol being every third day. Results are seen much more quickly with NPP as compared with Deca, and it’s quickly becoming a much more popular alternative.

Both supply as well as demand for NPP is high, because many underground labs have recently been producing it in large quantities to keep up with the increased demand. Although an effective weekly dose will be relatively inexpensive, it will still cost more than Deca, owing to the injection frequency that it necessitates. On the Black market, $75-100 is the average price for a ten milliliter bottle, dosed at 100-200 mgs/ml.

References:

1. Metabolism. 1990 Nov;39(11):1167-9

2. Effects of nandrolone decanoate on bone mineral content R, RighiGA, Turchetti V, Vattimo A.

3. AIDS. 1996 Jun;10(7):745-52

[JayDiesel Senior Member Find all posts View Profile Close JayDiesel]

Pharmaceutical Name: Nandrolone (with phenylpropionate ester)
Formula of Base: C18 H26 O2
Molecular Weight of Base: 274.4022
Molecular Weight of Ester: 150.174
Active life: 5 days
Anabolic/Androgenic Ratio: 125/37


Nandrolone is by far one of the most popular anabolic steroids available. This is due to the compound's affinity for being highly anabolic but relatively mild in terms of androgenic side effects. By attaching the phenylpropionate ester to the nandrolone base, the compound offers all of the advantages of nandrolone while also allowing it to reach blood concentration levels much more quickly than with the more popular decanoate ester.

Nandrolone phenylpropionate can be used to treat anemia by increasing red blood cell production, as do most anabolic steroids (1,2). However the rate at which nandrolone does this is somewhat higher than most. This increase in red blood cell count can help to improve an athlete's performance. This is accomplished by eliminating lactic acid much quicker and more efficiently, while also improving the delivery of oxygen to muscles (2,3). This increase in the production of red blood cells also allows muscle to recover much more quickly due to the blood being able to replenish muscle glycogen faster after physical exertion, as well as carrying those other components that aid in repair of muscles.

Medically, nandrolone is now often used to help treat patients with HIV or AIDS who are suffering from muscle wasting. However, due to the short active life of nandrolone phenylpropionate it would not be a very efficient ester to use. A longer acting ester would be more appropriate to administer in most cases.

Another benefit of nandrolone is the fact that it can improve collagen synthesis. This can help in improving joint pain, as well as their ability to function (3). Many users will often simply run nandrolone in their cycle for this specific effect. However users should be cautioned that the ability of nandrolone to heal or repair any serious damage to joints is rather small and should not relied upon for such a purpose. In fact, it may simply allow a user to do further damage to the joint without feeling the effects until much later. If using the compound for it's ability to improve the health of joints, ensure that it is not replacing proper medical treatment.

[JayDiesel Senior Member Find all posts View Profile Close JayDiesel]

Use/Dosing

Due to the active life of the compound most users will administer nandrolone phenylpropionate every day or every other day. However one could inject the compound as little as once every four days with no significant changes to the blood levels of the drug. Nandrolone phenylpropionate can be used either in bulking or cutting cycles. The lack of water retention associated with the drug makes it particular favorable for those who do not want to deal with bloat while running anabolic steroids.

The majority of inexperienced male users anecdotally report using 300-500mgs per week of the compound for their first cycle. Of course, these numbers can climb quite high depending on the level of experience that a user has with anabolics. Women also are able to use nandrolone phenylpropionate, as the potential and potency of the virilizing effects associated with the drug are quite muted if doses are kept moderate. Doses ranging from 50 to 200mgs per week have been anecdotally reported, but again these obviously can go higher.


Risks/Side Effects

Estrogenic effects are not a major concern with use of nandrolone. However it can cause progesterone-like effects in some users. Commonly reported sides effects associated with nandrolone are such things as acne/oily skin, insomnia, diarrhea, and nausea. These of course are coupled with the common side effects most often associated with anabolic steroids including testicular atrophy, gynecomastia (including lactation in some cases), and sexual dysfunction.

To combat sexual dysfunction most users will stack testosterone with nandrolone. The obvious choice to be used with nandrolone phenylpropionate is testosterone propionate as both compounds will not cause the majority of users to retain much water. How much testosterone one would need to take to ward off side effect associated with use of nandrolone and lack of natural testosterone production varies from individual to individual. Some have anecdotally reported that a low dose similar to 200mgs per week is enough. Others state that they need to run several hundreds more milligrams per week of testosterone than nandrolone to combat the effects. There is a small minority of individuals that also report having no sexual dysfunction from the drug even while running it without any type of testosterone. This variance again demonstrates that individuals will react to a compound differently than others.

Nandrolone is relatively safe in terms of a user's lipid profile and cholesterol. In some studies it has even been shown to actually improve HDL cholesterol levels (4). A major increase in a user's blood pressure or their liver toxicity should not be noticed with this compound either. Both are relatively mild in these respects.

Since nandrolone is a progestinic anabolic steroid, some special precautions need to be taken to ensure that side effects do not get out of control. Using compounds such as bromcriptine, cabergoline and/or vitamin b6 have all been shown and reported to help lower prolactin levels. The drug femera (letrozole) is also effective for use with nandrolone as it will regulate the progesterone and estrogen receptors in the body, therefore preventing some of the negative side effects associated with the compound.

A word of caution also for those that may plan on stacking nandrolone with trenbolone. Trenbolone is a strong progestin, much stronger than even nandrolone. By running these two compounds concurrently the user will suffer from extremely high levels of prolactin. This in turn will force the user to pay special attention to progesterone-like side effects and using compounds to prevent them, as well as having to run a particularly aggressive post-cycle therapy due to severe suppression of the hypothalamus pituitary testicular axis. Some users have anecdotally reported that they have suffered no ill effects of running the two compounds together, but it is a definite risk. One must weigh the costs versus the benefits.


References


1. Sundaram K, Kumar N, Monder C, Bardin CW., Different patterns of metabolism determine the relative anabolic activity of 19-norandrogens., J Steroid Biochem Mol Biol. 1995 Jun;53(1-6):253-7.

2. Bergink EW, Janssen PS, Turpijn EW, van der Vies J., Comparison of the receptor binding properties of nandrolone and testosterone under in vitro and in vivo conditions., J Steroid Biochem 1985 Jun;22(6):831-6

3. Triantafillopoulos IK, Banes AJ, Bowman KF Jr, Maloney M, Garrett WE Jr, Karas SG. Nandrolone decanoate and load increase remodeling and strength in human supraspinatus bioartificial tendons. PMID: 15150040 [PubMed - indexed for MEDLINE]

4.Sattler FR, Schroeder ET, Dube MP, Jaque SV, Martinez C, Blanche PJ, Azen S, Krauss RM. Metabolic effects of nandrolone decanoate and resistance training in men with HIV. Am J Physiol Endocrinol Metab. 2002 Dec;283(6): E1214-22

[craigdiaz Junior Member Find all posts View Profile Close craigdiaz]

What are the potential side effects of using GP Phenyl 100? geometry dash breeze asks.

[adamroot Junior Member Find all posts View Profile Close adamroot]

Thank you for sharing valuable information. Nice post. I enjoyed reading this post.My Chemical Romance The Black Parade Jacket