First Clenbuterol run

[bigbob007 Junior Member Find all posts View Profile Close bigbob007]

Yo i ordered some Clenbuterol i wont list the research place unles im allowed to, but i was wondering from people that have done it do you get a strength increase from it?and is it good to take first thing in the morning? I have ran Ephedrine before and i took it with 1 scoop of jaked or 1 scoop of craze could i do this with clen also or no? i had very good results with ephedrine i finally got my lower abs to pop which was incredibly hard to finally get.Will i get better results with clen or similar with the ephedrine.Thanks guys and no im not a total noob ill post some pics so you can judge me and give me some critiques and advice.

[ALEX.18 Senior Member Find all posts View Profile Close ALEX.18]

Some people do report strength increases but personally, speaking from only my own experience, no. I think thats more psychological than actual. Best time to take it is first thing in the morning at first. Once you get used to it and feel more comfortable with it, you may split up larger doses throughout the day. I do fasted cardio in the AM so the best time for me to take it is first thing when i open my eyes. That way by the time i actually start my cardio, its kicking in and burning even more fat than cardio alone. It just takes some thought and experience with it to figure out what will work best for you. No telling what kind of results you will get, every drug has a different effect on everyone

[ODB Senior Member Find all posts View Profile Close ODB]

Clenbuterol is anabolic but I have not felt any strength increase.
I take 1st thing am, I also drink 3-5 cups of coffee or green tea thru-out day when on it.

I only use it for 2wk cycles - recent research shows downgrade + increased myostatins wk 3.

here is an old post but a good one;
(Dan Duchaine to MM2000)

Whenever I use clenbuterol, it works great for about two weeks. After that, I can use ten tabs a day and my temperature will hardly rise. What can I do about this?

Clenbuterol is a beta-2 agonist. It attaches to the same receptor as your natural adrenaline and noradrenaline do. It has a very high bonding capacity to the adrenergic receptor. Whenever a drug fits well onto a cell receptor , the receptor becomes resistant to that drug. For example, the thermogenic effect of ephedrine seems to have a longer duration (though it's not as potent ) for two reasons: 1) ephedrine doesn't have a high receptor affinity, and 2) ephedrine is not beta-2 specific.

You might have heard about the newly discovered beta-3 receptors. The receptor is primarily a thermogenic messenger, and over half the thermogenic effect from ephedrine is from beta-3 stimulation. Although the thermogenic message is not as intense as the beta-2 message, beta-3 receptors are very resistant to down-regulation. Clenbuterol, however, has very little beta-3 stimulation.

Until some new synthetic beta-3 agonist is commercially available, the beta agonist of choice is still clenbuterol (although the stronger cimaterol is available as a research chemical in the U.S.). The rapid receptor sensitivity attenuation happens to all users, and the various dosage schemes (i.e., two days on, two days off) just aren't successful.

This attenuation and the lowering of above-normal body temperature are governed by two different mechanisms. I've written about one of them before: the shunting of T4 thyroid away from the active T3 form into the ineffective reverse-T3. Most of the thyroid in the body is the inactive T4 type. The active thyroid that actually fits onto thyroid receptors is a reduced T4, and reduced T4 occurs when one of the iodine atoms is cleaved off the molecule by a specific enzyme (deiodinase). Since we have no way of stopping the T4 from being transformed into ineffective reverse-T3 instead of

he active T3, and there's no such thing as injectable deiodinase (which would prevent the reduction), the best approach is to supplement the missing T3 with Cytomel, a synthetic T3.

The trouble is, it's likely a daily amount of Cytomel higher than 25 mcg would eventually stop the production of natural thyroid stimulating hormone (TSH), and the up-regulation will take about 8 weeks. Then, when you go off Cytomel, your body's still laggin' in production of TSH. So now you know why almost everybody who stops taking thyroid (with the exception of the drug Triacana) gets fat. For eight weeks, the body doesn't need as many calories.

Up to this point, the Cytomel trick was only a partial solution. The second and major decrease of body temperature is caused by the down-regulation of the beta-2 receptor. The receptor actually is still in the cell but not in its usual place. The receptor must be at the outside of the cell surface to be available to the beta agonist. There is research showing that the antihistamine ketotifen (trade name Zaditen by Sandoz) in large dosages will up-regulate the beta-2 receptors. This is similar to the American Periactin (cyproheptadine). This class of antihistamine will cause drowsiness, hunger, and irritability, but you may think the negative symptoms are a small price to play.

Here are the particulars. Zaditen is only available in France in 1-mg capsules , 60 capsules to a box. It sells for 65.10 francs (about $12.25). Because of its appetite-stimulating and muscle-building properties, Zaditen is sold through some of the American AIDS buying clubs. The average price for it in America is $40 a box. The dose needed for the up-regulation of the beta-2 receptors is about 10 capsules (10 mg)--assuming you've been using 3 clenbuterol tablets (60 mcg) each day. Sigma Chemicals, the company that has all the bodybuilding goodies that we like but can't buy (including steroids), does sell ketotifen (the fumarate version is water soluble) in raw bulk form. Keep in mind that even when used with clenbuterol, which both reduces appetite and is more of a stimulant than caffeine, Zaditen will still cause sleepiness and hunger. Those aren't nice effects, especially if you're dieting.

Your final solution to sustain clenbuterol's action is to use both Cytomel (25 mcg) and Zaditen (10 mg) each day after using clenbuterol by itself for 2 weeks . You'll need only 60 mcg of clenbuterol for a very pronounced thermogenic effect, hypothetically speaking, of course.

FYI - ketotifen knocks me the fuck out @ just 1mg, I cannot imagine 10mg per day...ZZZZZZZZZZZZ

[bigpa Senior Member Find all posts View Profile Close bigpa]

I am using clen now at 25mg for 2 weeks just to try it out. This is my first time taking it and it hits me hard. My hands shake and I get good energy from it. Will use seriously in the spring when I cut.