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Short Esters Are Better Esters
Perhaps the most important thing is that short-chain esters (steroids of shorter half life) yield a much higher plasma concentration of steroid than steroids of longer side chain esters.
In some study, a single 100 mg/ml x 1 ml intragluteal injection of nandrolone phenylpropionate caused a peak plasma concentration of almost double that of the 100 mg/ml x 1 ml intragluteal injection of nandrolone decanoate.
This level remained increased for almost seven days, too. By fourteen days, even though the nandrolone decanoate ester demonstrated a much higher plasma level than the nandrolone phenylpropionate level, the net amount of both was so low as to be ineffective.
This tells me that the effects I can see from using 500 mg of Testosterone enanthate per week probably won?t be the same as using 500 mg of Testosterone propionate or even Testosterone suspension per week. I?m going to see better results with the propionate and even better results with the suspension. Sure, I may need to inject the propionate and suspension more often, but in the long run it?ll pay off for me.
These assays all show that the half-lifes and clearence-time as we know them, don't actually exist. And that all suggestions made like b.e. in this thread are highly dependant on the carrier that is used to deliver the steroid. The half-life of a steroid is dependant on the estrification, the longer the ester chain the longer the bloodenzymes need to free the molecule (evasion time), but the invasion time (the time the steroid need to free itself from the oily depot into the watery blood ) is strongly dependant on the carrier/solvents. And the total half-life is the combination invasiontime-evasiontime.
The purpose of this thread is to provide some basic information on frontloading, including an explanation of half-lives, differences across esters, and recommended frontloading dosages.
HALF-LIFE BASICS
Each compound includes an ester that, along with other factors, controls the release of the hormone into the system. The rate of release differs by ester and is defined in terms of half-life. The average half-lives of esters are:
ESTER HALF LIFE (days)
Formate 1.5
Acetate 3
Propionate 4.5
Butyrate 6
Valerate 7.5
Hexanoate 9
Caproate 9
Isocaproate 9
Heptanoate 10.5
Enanthate 10.5
Octanoate 12
Cypionate 12
Nonanoate 13.5
Decanoate 15
Undecanoate 16.5
The half-life is the length of time (in days) to release half of the hormone into the system. For example, if 500 mgs of Testosterone Cypionate is administered, in 12 days, on average, 250 mgs of testosterone has been released into the system and 250 mgs of testosterone remains attached to the ester. In another 12 days, an additional 125 mgs (half of the remaining 250 mgs) has been released into the system for a total of 375 mgs released and 125 mgs still attached to the ester. The key detail is that different esters release the hormone into the system at different rates. Therefore, different esters require different frontload dosages.
FRONTLOADING
The purpose of frontloading is to quickly reach the target dosage to more quickly realize the benefits of the AAS. This thread provides instructions to reach 75% of the weekly dosage within the first week
Most people use, as a rule of thumb, twice the weekly dosage (double dosing) in the first week. That works well for esters with a half-life of 10.5 days or less. However, this does not work well for longer esters. Let?s look at EQ as an example. If the intended weekly dosage is 600 mgs, then the frontload dosage, based on double dosing, is 1200 mgs. Although 50% of the intended dosage is reached in the first week, 75% of the intended dosage is not reached until week 4. Without any frontloading, 75% of the intended dosage is reached in week 5. So, while ?double dosing? works, the effects diminish with increasing half-life.
EQ Double Dose Values at 600 mgs (1200 mgs in Week 1)
No Frontload
Released? % of Target
Week 1 153? 25%
Week 2 267? 44%
Week 3 352? 59%
Week 4 415? 69%
Week 5 462? 77%
Week 6 497? 83%
Double Dosing
Released? % of Target
Week 1 306? 51%
Week 2 381? 63%
Week 3 437? 73%
Week 4 478? 80%
Week 5 509? 85%
Week 6 532? 89%
The following table includes frontloading dosage to reach 75% of the intended dosage by the end of the first week. The dosages are indexed at 100 mgs / week. To reach your intended dosage, simply multiply the frontload dosage by your weekly dosage divided by 100. For example, if you wanted to run Testosterone Cypionate at 800 mgs / wk, then multiply the frontload dosage of 225 mgs by 8 (800 / 100) for 1800 mgs in week 1.
ESTER FRONTLOAD DOSAGE(mgs)
Formate 100
Acetate 100
Propionate 115
Butyrate 130
Valerate 160
Hexanoate 180
Caproate 180
Isocaproate 180
Heptanoate 200
Enanthate 200
Octanoate 225
Cypionate 225
Nonanoate 250
Decanoate 270
Undecanoate 295
The calculation used is MgDL = MgD * (1/2)^(D/HL), where:
MgDL = Mgs of depot left
MgD = Mgs in depot (total)
D = Days
H = Half-life
Injections for Formate and Acetate are daily. Injections for Propianate are every other day. Injections for Butyrate are every 3 days. All other esters are administered as one injection at the beginning of the week 1. It should be noted that injection frequency does not significantly influence frontloading dosages.
Perhaps the most important thing is that short-chain esters (steroids of shorter half life) yield a much higher plasma concentration of steroid than steroids of longer side chain esters.
In some study, a single 100 mg/ml x 1 ml intragluteal injection of nandrolone phenylpropionate caused a peak plasma concentration of almost double that of the 100 mg/ml x 1 ml intragluteal injection of nandrolone decanoate.
This level remained increased for almost seven days, too. By fourteen days, even though the nandrolone decanoate ester demonstrated a much higher plasma level than the nandrolone phenylpropionate level, the net amount of both was so low as to be ineffective.
This tells me that the effects I can see from using 500 mg of Testosterone enanthate per week probably won?t be the same as using 500 mg of Testosterone propionate or even Testosterone suspension per week. I?m going to see better results with the propionate and even better results with the suspension. Sure, I may need to inject the propionate and suspension more often, but in the long run it?ll pay off for me.
These assays all show that the half-lifes and clearence-time as we know them, don't actually exist. And that all suggestions made like b.e. in this thread are highly dependant on the carrier that is used to deliver the steroid. The half-life of a steroid is dependant on the estrification, the longer the ester chain the longer the bloodenzymes need to free the molecule (evasion time), but the invasion time (the time the steroid need to free itself from the oily depot into the watery blood ) is strongly dependant on the carrier/solvents. And the total half-life is the combination invasiontime-evasiontime.
The purpose of this thread is to provide some basic information on frontloading, including an explanation of half-lives, differences across esters, and recommended frontloading dosages.
HALF-LIFE BASICS
Each compound includes an ester that, along with other factors, controls the release of the hormone into the system. The rate of release differs by ester and is defined in terms of half-life. The average half-lives of esters are:
ESTER HALF LIFE (days)
Formate 1.5
Acetate 3
Propionate 4.5
Butyrate 6
Valerate 7.5
Hexanoate 9
Caproate 9
Isocaproate 9
Heptanoate 10.5
Enanthate 10.5
Octanoate 12
Cypionate 12
Nonanoate 13.5
Decanoate 15
Undecanoate 16.5
The half-life is the length of time (in days) to release half of the hormone into the system. For example, if 500 mgs of Testosterone Cypionate is administered, in 12 days, on average, 250 mgs of testosterone has been released into the system and 250 mgs of testosterone remains attached to the ester. In another 12 days, an additional 125 mgs (half of the remaining 250 mgs) has been released into the system for a total of 375 mgs released and 125 mgs still attached to the ester. The key detail is that different esters release the hormone into the system at different rates. Therefore, different esters require different frontload dosages.
FRONTLOADING
The purpose of frontloading is to quickly reach the target dosage to more quickly realize the benefits of the AAS. This thread provides instructions to reach 75% of the weekly dosage within the first week
Most people use, as a rule of thumb, twice the weekly dosage (double dosing) in the first week. That works well for esters with a half-life of 10.5 days or less. However, this does not work well for longer esters. Let?s look at EQ as an example. If the intended weekly dosage is 600 mgs, then the frontload dosage, based on double dosing, is 1200 mgs. Although 50% of the intended dosage is reached in the first week, 75% of the intended dosage is not reached until week 4. Without any frontloading, 75% of the intended dosage is reached in week 5. So, while ?double dosing? works, the effects diminish with increasing half-life.
EQ Double Dose Values at 600 mgs (1200 mgs in Week 1)
No Frontload
Released? % of Target
Week 1 153? 25%
Week 2 267? 44%
Week 3 352? 59%
Week 4 415? 69%
Week 5 462? 77%
Week 6 497? 83%
Double Dosing
Released? % of Target
Week 1 306? 51%
Week 2 381? 63%
Week 3 437? 73%
Week 4 478? 80%
Week 5 509? 85%
Week 6 532? 89%
The following table includes frontloading dosage to reach 75% of the intended dosage by the end of the first week. The dosages are indexed at 100 mgs / week. To reach your intended dosage, simply multiply the frontload dosage by your weekly dosage divided by 100. For example, if you wanted to run Testosterone Cypionate at 800 mgs / wk, then multiply the frontload dosage of 225 mgs by 8 (800 / 100) for 1800 mgs in week 1.
ESTER FRONTLOAD DOSAGE(mgs)
Formate 100
Acetate 100
Propionate 115
Butyrate 130
Valerate 160
Hexanoate 180
Caproate 180
Isocaproate 180
Heptanoate 200
Enanthate 200
Octanoate 225
Cypionate 225
Nonanoate 250
Decanoate 270
Undecanoate 295
The calculation used is MgDL = MgD * (1/2)^(D/HL), where:
MgDL = Mgs of depot left
MgD = Mgs in depot (total)
D = Days
H = Half-life
Injections for Formate and Acetate are daily. Injections for Propianate are every other day. Injections for Butyrate are every 3 days. All other esters are administered as one injection at the beginning of the week 1. It should be noted that injection frequency does not significantly influence frontloading dosages.
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