Nebido [testosterone undecanoate]

[WAYNEB0354 Junior Member Find all posts View Profile Close WAYNEB0354]

Relatively new,seems like a no-brainer
has anyone had experience with this compound?

[boza Junior Member Find all posts View Profile Close boza]

Nebido is used as HRT in sweden (hormone replacement therapy). I would use this testo anyday over C / E / P but doctors inject 1000mg each 6weeks or something so that you wont go "unnatural" lol. its a long ester so id suggest e5d / e7d injections with it. wish i cud get a hold of it.

[RonnyT Senior Member Find all posts View Profile Close RonnyT]

Nebido is a new compound created to maintain a steady hormone level over a prolonged period (to prevent frequent visits to the PD for injections) The first one was Sustanon. Testosterone undecanoate is a very long estrification that stays even longer in your system because of the carrier. When research showed that castor oil (vs cottonseed oil) prolonged the effectivity of the solved estrificated hormone it released lots of discussion because now it was (scientifically) proven that the carriers and carrier oil influenced the half life of the solvae, something that was (until then) only known by expirienced bodybuilders. The same is true for the perservatives and co-solvents that together form the complete carrier. We have these compounds in the lab right now and will make this visisble in the new site..
Nebido on napsgear.net

[BFG Junior Member Find all posts View Profile Close BFG]

It's not new by any means, undecanoate is on the market for quite some time.. Organon's Restandol anyone? Andriol?
You need loads of that to get you anywhere - it's girls stuff. But the thing with undecanoate is, it bypasses liver processing due to it's ester hocus pocus..

[RonnyT Senior Member Find all posts View Profile Close RonnyT]

You mix the old oral version with the newer Testsoterone undecanoate injectable

It's not new by any means, undecanoate is on the market for quite some time.. Organon's Restandol anyone? Andriol?
You need loads of that to get you anywhere - it's girls stuff. But the thing with undecanoate is, it bypasses liver processing due to it's ester hocus pocus..

J Androl. 1998 Nov-Dec;19(6):761-8.

A pharmacokinetic study of injectable testosterone undecanoate in hypogonadal men.
Zhang GY, Gu YQ, Wang XH, Cui YG, Bremner WJ.

National Research Institute for Family Planning (World Health Organization Collaborating Center for Research in Human Reproduction), Beijing, People's Republic of China.

Abstract
Testosterone undecanoate (TU) provides testosterone (T) replacement for hypogonadal men when administered orally but requires multiple doses per day and produces widely variable serum T levels. We investigated the pharmacokinetics of a newly available TU preparation administered by intramuscular injection to hypogonadal men. Eight patients with Klinefelter's syndrome received either 500 mg or 1,000 mg of TU by intramuscular injection; 3 months later, the other dose was given to each man (except to one, who did not receive the 1,000-mg dose). Serum levels of reproductive hormones were measured at regular intervals before and after the injections. Mean serum T levels increased significantly at the end of the first week, from less than 10 nmol/L to 47.8+/-10.1 and 54.2+/-4.8 nmol/ L for the lower and higher doses, respectively. Thereafter, serum T levels decreased progressively and reached the lower-normal limit for adult men by day 50 to 60. Pharmacokinetic analysis showed a terminal elimination half-life of 18.3+/-2.3 and 23.7+/-2.7 days and showed a mean residence time of 21.7+/-1.1 and 23.0+/-0.8 days for the lower and higher doses, respectively. The area under the serum T concentration-time curve and the T-distribution value related to serum T concentration were significantly higher following the 1,000-mg dose than following the 500-mg dose. The 500-mg dose, when given as the second injection, yielded optimal pharmacokinetics (defined as mean peak T values not exceeding the normal range and persistence of normal levels for at least 7 weeks), suggesting that repeated injections of 500 mg at 6-8-week intervals may provide optimal T replacement. The mean serum levels of estradiol were normalized following the injections, and prolactin levels were normal throughout the study. Significant decrease of serum luteinizing hormone (LH) and follicle-stimulating hormone (FSH) levels was observed, with the decrease in LH levels being more pronounced. There were no significant differences in serum LH and FSH levels between the two doses. Sex hormone-binding globulin (SHBG) levels before any T therapy were near the upper limit of normal for adult men and were reduced by approximately 50% just prior to the second dose of TU. The decreased SHBG levels produced by the first TU injection could have led to lower peak total T levels and to a more rapid clearance of T following the second TU injection. We conclude that single-dose injections of TU to hypogonadal men can maintain serum T concentration within the normal range for at least 7 weeks without immediately apparent side effects. It is likely that this form of T would require injections only at 6-8-week or longer intervals, not at the 2-week intervals necessary with currently used T esters (enanthate and cypionate). This injectable TU preparation may provide improved substitution therapy for male hypogonadism and, in addition, may be developed as an androgen component of male contraceptives.

PMID: 9876028