more Testosterone Studies Please

[ODB Senior Member Find all posts View Profile Close ODB]

I like to read + learn from these (so please find more and add them here.) ;

Testosterone dose-response relationships in healthy young men

http://ajpendo.physiology.org/content/281/6/E1172.full

Sixty-one eligible men were randomly assigned to one of five groups. All received monthly injections of a long-acting GnRH agonist to suppress endogenous testosterone production. In addition, group 1 received 25 mg of testosterone enanthate intramuscularly weekly;group 2, 50 mg testosterone enanthate; group 3, 125 mg testosterone enanthate; group 4, 300 mg testosterone enanthate; and group 5, 600 mg testosterone enanthate. Twelve men were assigned to group 1, 12 to group 2, 12 to group 3, 12 to group 4, and 13 togroup 5. Testosterone and GnRH agonist injections were administered by the General Clinical Research Center staff to assure compliance.

FF to results;
Given the results of the study and based on years of personal experience I believe the first time user can safely use between 300-600 mg of testosterone enanthate or cypionate per week for 8-12 weeks. Because it is desirable to have even blood androgen levels I advise at least 2 equal injections per week. Testosterone cypionate peaks within 1-2 days after injection and falls off to almost baseline by day 10. Therefore waiting 7 days between injections of cypionate would cause wide fluctuations in blood androgen levels.


thanks

[ODB Senior Member Find all posts View Profile Close ODB]

1527 Articles on AAS ; http://ajpendo.physiology.org/search...it=yes&x=0&y=0

[ODB Senior Member Find all posts View Profile Close ODB]

HPGA Normalization Protocol

HPGA Normalization Protocol After Androgen Treatment
N Vergel, AL Hodge, MC Scally
Program for Wellness Restoration, PoWeR

Objective
Results Discussion
To develop an approach to cycle androgens that would
result in significant changes in body composition and
accelerate the normalization of the hypothalamic
pituitary gonadal axis (HPGA) after cessation of
androgens.

Methods
An uncontrolled study of 19 HIV-negative eugonadal
men, ages 23 ? 57 years, administered testosterone
cypionate and nandrolone decanoate for 12 weeks,
and then were treated simultaneously with a combined
regimen of human chorionic gonadotropin (hCG) (2500
IU/QODx16d), clomiphene citrate (50 mg PO BID x 30d)
and tamoxifen (20 mg PO QD x 45d), to restore the
HPGA.
Results
Mean FFM by DEXA increased from 64.1 to 69.8 kg
(p<.001); percent body fat decreased from 23.6 to 20.9
(p<.01); strength increased significantly from 357.4 lb
to 406.4 lb (p=.02). No significant changes in serum
chemistries and liver function tests were found. HDL-C
decreased from a mean value of 44.3 to 38.0 (p=.02).

Mean values for luteinizing hormone (LH) and total
testosterone (T) were 4.5 and 460, respectively prior
to androgen treatment. At the conclusion of the 12-
week treatment with androgens the mean LH <0.7
(p<.001) and total testosterone was 1568 (p<.001). The
mean values after treatment with the combined
regimen were LH=6.2 and testosterone=458.
Discussion
The use of androgens has been reported to improve
lean body mass, strength, sexual function, and mood
accompanied by side effects caused by continuous
uninterrupted use of these compounds (polycythemia,
testicular atrophy, hypertension, liver dysfunction
[oral androgens] and alopecia.) Androgen-induced
HPGA suppression causes a severe hypogonadal state in
most patients that often require an extensive period of
considerable duration for normalization. This prevents
most if not all individuals from cycling off these
medications due to the adverse impact of this state on
their previously gained LBM and quality of life. The
protocol of hCG-clomiphene-tamoxifen was successful
in restoring the HPGA within 45 days after androgen
cessation. Further controlled studies are needed to
determine if these results can be duplicated in HIVpositive

[ODB Senior Member Find all posts View Profile Close ODB]

Frequency of Administration -
Testosterone & Nandrolone
http://www.medibolics.com/freq2.htm