Cycle Risk?

[mega0888 Senior Member Find all posts View Profile Close mega0888]

Anyone ever taken some molly while on a cycle ? What kid of risk should one take into account when doing so?

[ODB Senior Member Find all posts View Profile Close ODB]

Disruption of the discriminative stimulus effects of (+)-3,4-methylenedioxymethamphetamine (MDMA) by
AU: Author
Virden, Thomas Barnes, Iii
AF: Author Affiliation
Western Michigan U, US [Virden]
SO: Source
Dissertation Abstracts International: Section B: The Sciences & Engineering. Vol 59(7-B), Jan 1999, pp. 3764
IS: ISSN
0419-4217 (Print)
PB: Publisher
US: Univ Microfilms International
AB: Abstract
It is well established that repeated, high doses of 3, 4-methylenedioxymethamphetamine (MDMA) result in the long-term depletion of serotonin levels and destruction of serotonergic terminals in various locations in the brains of a variety of species. Further, it is also well known that concomitant injections of the serotonin reuptake inhibitor, fluoxetine, prevents this deterioration. It has recently been noted that such MDMA neurotoxicity disrupts stimulus control in rats trained to discriminate MDMA from saline in a drug discrimination procedure (Schechter, 1991a). In order to extend Schechter's findings to the optical isomers of MDMA and to explore the potential of fluoxetine for the prevention of the disruption of the isomers' discriminative stimulus control by neurotoxicity, rats were trained to discriminate either (+)-MDMA or (-DMA in a two-lever water reinforced operant procedure. Most of the rats administered (-DMA died during the neurotoxic administration, obviating any conclusions thereof. However, the stimulus control by (+)-MDMA was maintained in rats administered concomitant injections of fluoxetine and the neurotoxic dose of ()-MDMA, but disrupted in those that received ()-MDMA with concomitant saline injections. Control by (+)-MDMA was reestablished in these latter rats with subsequent training sessions. Postmortem neurochemical analysis verified the neurotoxic effects of the ()-MDMA injection regimen in that serotonin and its major metabolite 5-HIAA were significantly diminished in the prefrontal cortices in rats given ()-MDMA relative to control. Conversely, serotonin levels in rats administered concomtitant ()-MDMA and fluoxetine injections were unaffected relative to control, indicating pharmacological protection against MDMA neurotoxicity. The deaths of the (-DMA rats are discussed in light of the predominant environmental variables, and it is suggested that elevated temperatures during ()-MDMA treatment may have contributed to their mortality. However, the results from the surviving rats indicate that the discriminative stimulus control of (+)-MDMA as disrupted by ()-MDMA neurotoxicity can be established, regained, and protected against. Although there appears to be a relative paucity in research regarding the behavioral consequences MDMA neurotoxicity, the present findings shed new light on the potential use of fluoxetine as a tool for such explorations. (PsycINFO Database Record (c) 2002 APA, all rights reserved)
LA: Language
English
PY: Publication Year
1999
PT: Publication Type
Print (Paper); Dissertation Abstract; Empirical Study
PO: Population
Animal
FE: Features
Peer Reviewed
DE: Descriptors
*Animal Ethology; *Methylenedioxymethamphetamine; *Operant Conditioning; *Rat Learning
ID: Identifiers
-3; 4-methylenedioxymethamphetamine; two-level water reinforced operant responding; rats
CL: Classification
2100 General Psychology; 2500 Physiological Psychology & Neuroscience

[ShaneRoggins Member Find all posts View Profile Close ShaneRoggins]

I take molly, or pressed pills maybe once a month, and do so while on. You have to make your own choice on this, because everyone is different, but for me personally, when I do take it, I do so in moderation, and I haven't had any issues. This probably isn't the best place to be asking this either, so I would suggest asking your question in the steroid forms on bluelight.ru, where you will find like minded people who are on cycles, and take ecstasy.