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The Korean pharmaceutical company LG Life Sciences has been producing the growth hormone Declage since 2007. It's available in Korea and some neighbouring countries, but not yet elsewhere in the world. [Asia Pacific Biotech 2008;12(3):22-8.] Once Declage becomes more widely available then thousands of chemical athletes might be able to add another interesting concoction to their arsenal. Declage contains LB03002, a nanotechnological growth hormone application that users only need to inject once a week.
LB03002 is an MCT oil-based injectable. The oil contains myriads of small globules of hyaluronic acid. The growth hormone molecules are confined within these globules and after injection they gradually ooze out. Think of LB03002 as a growth hormone depot, which you can inject subcutaneously into the abdomen, like insulin.
The trials required before LB03002 can be launched in the US, Canada or the EU are still underway. Publications with data from the trials have been appearing since 2006 and these are positive. [PubMed]
One of these was published in 2006 by researchers at the Ludwig-Maximilians Universitaet in Munich and presented the results of a small human study. [J Clin Endocrinol Metab. 2006 Aug;91(8):2926-30.] The figure below is taken from this. It shows the growth hormone levels of adult test subjects who either produced no or insufficient amounts of growth hormone.
After being injected with a regular growth hormone preparation the level drops quickly, but after being injected with LB03002 the subjects' growth hormone level remained high for a number of days, even when they were given weekly injections of the substance for a period of 5 weeks [W5].
In 2011 doctors at Massachusetts General Hospital published the results of a larger human study. [J Clin Endocrinol Metab. 2011 Jun;96(6):1718-26.] In this study, fifty test subjects with adult growth hormone deficiency were given a weekly injection with a placebo [white blocks] for six months. One hundred subjects were given a weekly subcutaneous injection containing LB03002 [grey blocks]. During the period that the experiment lasted the LB03002 group lost one kilogram of fat and their lean body mass increased by two kilograms.
Many chemical athletes use growth hormone because it boosts the synthesis of the hormone IGF-1. IGF-1 is strongly anabolic. When doctors at the Massachusetts General Hospital gave adult subjects with growth hormone deficiency weekly injections of LB03002 for two consecutive periods of six months, they observed that the concentration of IGF-1 rose sharply during the first weeks after the injections as a result. [Pituitary. 2012 Aug 23. [Epub ahead of print].]
IGF-1 remains active in the blood if it can attach itself to the binding protein IGF-BP-3.
A trial has even been published in which children with retarded growth as a result of growth hormone deficiency were successfully given LB03002 for three years in a row. [J Clin Endocrinol Metab. 2012 Feb;97(2):400-7.]
LG Life Sciences has asked the FDA to approve LB03002. [ASD Reports 7 March 2012] Approval is still pending.
Analysts have great expectations for LB03002. If users only have to inject once a week, they reason, then the number of growth hormone users in pursuit of an anti-aging solution may well rise dramatically.
Source:
J Clin Endocrinol Metab. 2012 Feb;97(2):400-7.
More:
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Taking GHB every day won't boost your growth hormone secretion 14.02.2013
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Secret weapon against sports injuries? It's called growth hormone 19.07.2012
Capromorelin: Pfizer's oral growth hormone booster 25.01.2011
3N-GH lasts 24 times as long as regular growth hormone 07.12.2010
Study looks at effects of 16 weeks of growth hormone and testosterone 21.10.2010
Study shows effect of six months on T-enanthate and Nutropin 11.05.2010
Growth hormone pill works 05.11.2009
LB03002 is an MCT oil-based injectable. The oil contains myriads of small globules of hyaluronic acid. The growth hormone molecules are confined within these globules and after injection they gradually ooze out. Think of LB03002 as a growth hormone depot, which you can inject subcutaneously into the abdomen, like insulin.
The trials required before LB03002 can be launched in the US, Canada or the EU are still underway. Publications with data from the trials have been appearing since 2006 and these are positive. [PubMed]
One of these was published in 2006 by researchers at the Ludwig-Maximilians Universitaet in Munich and presented the results of a small human study. [J Clin Endocrinol Metab. 2006 Aug;91(8):2926-30.] The figure below is taken from this. It shows the growth hormone levels of adult test subjects who either produced no or insufficient amounts of growth hormone.
After being injected with a regular growth hormone preparation the level drops quickly, but after being injected with LB03002 the subjects' growth hormone level remained high for a number of days, even when they were given weekly injections of the substance for a period of 5 weeks [W5].
In 2011 doctors at Massachusetts General Hospital published the results of a larger human study. [J Clin Endocrinol Metab. 2011 Jun;96(6):1718-26.] In this study, fifty test subjects with adult growth hormone deficiency were given a weekly injection with a placebo [white blocks] for six months. One hundred subjects were given a weekly subcutaneous injection containing LB03002 [grey blocks]. During the period that the experiment lasted the LB03002 group lost one kilogram of fat and their lean body mass increased by two kilograms.
Many chemical athletes use growth hormone because it boosts the synthesis of the hormone IGF-1. IGF-1 is strongly anabolic. When doctors at the Massachusetts General Hospital gave adult subjects with growth hormone deficiency weekly injections of LB03002 for two consecutive periods of six months, they observed that the concentration of IGF-1 rose sharply during the first weeks after the injections as a result. [Pituitary. 2012 Aug 23. [Epub ahead of print].]
IGF-1 remains active in the blood if it can attach itself to the binding protein IGF-BP-3.
A trial has even been published in which children with retarded growth as a result of growth hormone deficiency were successfully given LB03002 for three years in a row. [J Clin Endocrinol Metab. 2012 Feb;97(2):400-7.]
LG Life Sciences has asked the FDA to approve LB03002. [ASD Reports 7 March 2012] Approval is still pending.
Analysts have great expectations for LB03002. If users only have to inject once a week, they reason, then the number of growth hormone users in pursuit of an anti-aging solution may well rise dramatically.
Source:
J Clin Endocrinol Metab. 2012 Feb;97(2):400-7.
More:
Quarter of juicing bodybuilders use growth hormone 02.03.2013
Taking GHB every day won't boost your growth hormone secretion 14.02.2013
The short-lived effects of an anti-aging course of testosterone and growth hormone 12.02.2013
Secret weapon against sports injuries? It's called growth hormone 19.07.2012
Capromorelin: Pfizer's oral growth hormone booster 25.01.2011
3N-GH lasts 24 times as long as regular growth hormone 07.12.2010
Study looks at effects of 16 weeks of growth hormone and testosterone 21.10.2010
Study shows effect of six months on T-enanthate and Nutropin 11.05.2010
Growth hormone pill works 05.11.2009
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