compounding cyclodextrines

[RonnyT]

CD are like a donut right? You can just mix together CD and a drug(AAS or Cialis-Viagra) or it's more complex? The drug "go in the hole of the CD" just mixing the 2 compounds?

Yep and then the CD's push the drug through your mucous membranes (underneath the tongue and inside cheek) into the system, without the fist pass through the liver. Thats why it works very quick (its used with medication at a heartattack) and has a high deliverypercentage. Its also usefull to deliver compounds like halotestin that are harsh on the liver.

[dino]

Maybe a "Chemical warriors" subforum could be appreciated...i love to read article about homebrewing and to see photos of these magic kitchen?

[dino]

CD are like a donut right? You can just mix together CD and a drug(AAS or Cialis-Viagra) or it's more complex? The drug "go in the hole of the CD" just mixing the 2 compounds?

[AwesomeSmiley]

Lol you're like some crazy chemist teacher I had back in the school days. This goes way over my head, but I do find it interesting. I just stick to maths

[RonnyT]

interest

If there is any interest in this subject I'll post some more information

[RonnyT]

Do we have home brewers cq kitchenbrewers on our forum? Anyone tried to make complexes in tabletform or sublingual drops? At the moment I'm experimentin with Cialis and Vardenafil. They are the most easy compounds to check if it works okay. Either you get hard on or you don't. You know within the hour. If you complex a dteroid it takes longer


The best tool available to make nasal and sublingual steroids are derivatives of beta cyclodextrins. The one that is most readily available is hydroxypropyl-beta cyclodextrin (HPBCD). (Note: Plain beta-cyclodextrin is of little use) In case you have not heard of these, cyclodextrins are cyclic oligosaccarides (sugars) that have a hydrophilic outer surface and a hydrophobic inner surface.(3) They can be thought of as a doughnut, with the centre capable of having a steroid molecule stuck inside it. The hydrophilic outer surface makes the cyclodextrin soluble in water, and when it is combined with a steroid, it can make the poorly water soluble steroid soluble as well.(3) In addition to making steroids soluble, cyclodextrins have very other important properties that make them ideal for our purpose. Cyclodextrins are known to enhance steroid delivery through biological membranes.(3) The large CDs themselves are very bad at permeating biological membranes, but they deliver the steroid to the membrane, where it partitions into the membrane, leaving the CD on the outside of the membrane.(3) The conventional penetration enhancers like alcohols or polyethylene glycol act by disrupting the lipid layers of membranes.(3) That is a big source of irritation from the old formula, and this irritation can thus be avoided by the use of CD?s. Another advantage is, once administered, the steroid is rapidly absorbed. Nearly 95% of the steroid will be absorbed within 20 minutes. This also causes the need for multiple doses throughout the day.