Half life injections once or twice a week

[RonnyT Senior Member Find all posts View Profile Close RonnyT]

I posted an article here: http://juicedmuscle.com/jmblog/conte...-and-half-life

About the injection frequency:
You are running 800mg of TestC per week. After 12 days according to some information, you would still have 400mg active in your body, this is enough to inject once a week. If you are doing 200 mg of TestC, you need to inject two times per week to prevent your active testosterone levels to become to low.

[big1 Senior Member Find all posts View Profile Close big1]

Good to know.
I always divide injections if I'm using long esters.

[RonnyT Senior Member Find all posts View Profile Close RonnyT]

more specific information

higher mg/ml content results in a longer terminal halflife

In a study by Schulte-Beerbuhl M et al (1) they found that 140mg of cyp (single injection) returned to basal levels by day 10, that would be a terminal halflife of 5 days. In another study done by Nankin HR(2) with a single injection of 200mg of cyp, test levels returned to baseline after 13 to 15 days, that would be a terminal halflife of 6.5 to 7days. So it would seem that higher mg/ml content would result in a longer terminal halflife in the order of a few days.

In a study by Zhang et al (3) they demonstrated that the half life of TU was increased from 18 to 23 days by increasing the single injection size from 2ml to four ml at the same concentration. (500mg tot. to 1000mg tot). The issue of larger bolus sizes is also addressed in the oft quoted minto study (4) "Injection technique, including injection site, volume and concentration, as well as the nature of the vehicle, could theoretically be important for androgen ester release rate." The minto study also brings up the importance of the vehicle (oil) and the impact this has on the release rate of the ester and halflife of the drug a good example of this is a study done by Behre et al (5) which demonstrated ~50% increase in halflife using castor oil vs tea tree oil.
The Minto study also pointed out that injection site makes a huge difference in bioavailablity and other pharmacokinetics of drugs noting that gluteal injections are much more "efficient" than deltoid. This may likely be due to muscle type.

What does all of this mean? In the minto study, the individual results were fairly diverse reinforcing what we already knew, that different individuals respond differentlly. It would also seem that injection volume, concentration, vehicle, and sites are the other important variables. As you can see, anyone who just plugs their doses into any of the commonly available steroid spreadsheets is still operating in the dark.



1. Schulte-Beerbuhl M et al., Comparison of testosterone, dihydrotestosterone, luteinizing hormone, and follicle-stimulating hormone in serum after injection of testosterone enanthate or testosterone cypionate. Fertility and Sterility (1980) 33.2 : 201-203.

2. Nankin HR, Hormone kinetics after intramuscular testosterone cypionate. Fertility and Sterility (1987) Jun; 47.6 : 1004-1009.

3. J Androl. 1998 Nov-Dec;19(6):761-8.
A pharmacokinetic study of injectable testosterone undecanoate in hypogonadal men.

4. Pharmacokinetics and Pharmacodynamics of Nandrolone Esters in Oil Vehicle: Effects of Ester, Injection Site and Injection Volume1
Charles F. Minto, Christopher Howe, Susan Wishart, Ann J. Conway and David J. Handelsman
http://jpet.aspetjournals.org/cgi/content/full/281/1/93

5. Eur J Endocrinol. 1999 May;140(5):414-9.
Intramuscular injection of testosterone undecanoate for the treatment of male hypogonadism: phase I studies.

[player Senior Member Find all posts View Profile Close player]

Example (the same as what you can read on blog):you take testosteron with an attached ester cypionate, at 1000mg weekly, for 10 weeks.After 48(!) days from your last shoot,in your body still circulating~ 67.5mg testo cyp.If this ammount is still suppressive (why not would be,becouse it's still at least eight times higher what your body can produce daily,plus it's taken exogenous) you can't starting the PCT procedure...Every advanced user know,if you not started PCT after a course,(or a new cycle) you lost a lot of "muscle" in relatively short time.
And here is the big question,when can we start a PCT??Another question is,if you used hcg through the whole 10 weeks,(esp. 2x 250IU weekly) you need to stop after the last shoot,or you must it take,and stop before when the PCT started??
It's a very complex subject.

Other...Ronny,whats your opinion about frontloading?Working,or just a waste of time,something?

[iamready Senior Member Find all posts View Profile Close iamready]

Good question. I am planning on running 750mg sust per week and hcg threw the entire cycle. When would I discontinue hcg and when do I start nolva.

My initial plan was stop hcg 3 weeks after last pin and start nolva the next day

[roachboy101 Member Find all posts View Profile Close roachboy101]

example (the same as what you can read on blog):you take testosteron with an attached ester cypionate, at 1000mg weekly, for 10 weeks.after 48(!) days from your last shoot,in your body still circulating~ 67.5mg testo cyp.if this ammount is still suppressive (why not would be,becouse it's still at least eight times higher what your body can produce daily,plus it's taken exogenous) you can't starting the pct procedure...every advanced user know,if you not started pct after a course,(or a new cycle) you lost a lot of "muscle" in relatively short time.
And here is the big question,when can we start a pct??another question is,if you used hcg through the whole 10 weeks,(esp. 2x 250iu weekly) you need to stop after the last shoot,or you must it take,and stop before when the pct started??
It's a very complex subject.

Other...ronny,whats your opinion about frontloading?working,or just a waste of time,something?

bumppppppppp!

[RonnyT Senior Member Find all posts View Profile Close RonnyT]

Frontloading is usefull when you work a cycle for competition, just like for competition you end with short estrifications, or athletes to prevent dopingcontrols. If you use mixed compounds (Sustanon) in fact you are frontloading - loading, then you can change to longer estrifications (like enenthate) after a few weeks, but your "on steam" almost imidiatly when you start injecting. The same goes for ending, if you stop injecting longer estrifications of whatever parentcompound (testosterone - trenbolone etc), the effect slowly declines.

On the net you find al kinds od math when exactly the effective dose is lower then endogenous and then you should start PCT. I.m.o. nonsense, just read whar Roberts etc also claim you can use Nolva clomid etc etc next to your cycle, Like I read here in this thread, if you wait to long you'll loose muscle, be sure to start in time. If you can in PCT use HMG or HMG and HCG etc ..but mimic LH AND FSH and in the mean time clomid and nolva to recover endogenous production.


In the last weeks of the cycle Proviron (increase in ejaculatory volume). For Bodypage I wrote about pornactors the one I know used a combo of proviron and winny for this reason. I'll translate the article when I can find the time. On PCT read the blog..

[player Senior Member Find all posts View Profile Close player]

Personally I' am interested about reading articles from Bodypage.nl
Hope you can upload more..

[RonnyT Senior Member Find all posts View Profile Close RonnyT]

posted one today..

Personally I' am interested about reading articles from Bodypage.nl
Hope you can upload more..

[ODB Senior Member Find all posts View Profile Close ODB]

more specific information

higher mg/ml content results in a longer terminal halflife

"Injection technique, including injection site, volume and concentration, as well as the nature of the vehicle, could theoretically be important for androgen ester release rate."
The Minto study also pointed out that injection site makes a huge difference in bioavailablity and other pharmacokinetics of drugs noting that gluteal injections are much more "efficient" than deltoid. This may likely be due to muscle type.
.

injections Sites

Another thing that superficially seems trivial but makes a huge difference in plasma steroid concentrations is where you inject. That?s right, this seems utterly trivial but this study concluded that gluteal injections yielded far superior plasma levels as opposed to injections in the deltoid.

Of all the locations that nandrolone injections were given in this study (100 mg/ml x 1 ml in the glutes, 25 mg/ml x 4 ml in the glutes and 100 mg/ml x 1 ml in the deltoid), the deltoid injections yielded the lowest plasma levels of nandrolone by a huge factor, with peak concentrations being 50% lower than the 100 mg/ml gluteal injection and around 10% lower than the 100 mg/ml x 4ml gluteal injection. Lesson learned here: Only inject in the glutes for maximal steroidal efficacy.

Reference

The Journal of Pharmacology And Experimental Therapeutics, Vol 281, No. 1; 93-102, 1997.
http://jpet.aspetjournals.org/cgi/reprint/281/1/93.pdf

[RonnyT Senior Member Find all posts View Profile Close RonnyT]

organon

..and this time results on human beings instead of rodents and decent dosages what else would you expect from a Dutch company

[big1 Senior Member Find all posts View Profile Close big1]

NIce to hear.
But how can i inject 5ml of primo, 2ml of enanthate and 4ml of masteron per week all in glutes?

[ment to juice Senior Member Find all posts View Profile Close ment to juice]

Def injects to glutes is the way to go but no way can u do it all time ill use shoulder and glutes to split it up that's all I ever used and when that gets to be to much bi s or inner thighs

[player Senior Member Find all posts View Profile Close player]

posted one today..

Very good,many thanks!

[RonnyT Senior Member Find all posts View Profile Close RonnyT]

NIce to hear.
But how can i inject 5ml of primo, 2ml of enanthate and 4ml of masteron per week all in glutes?

I dunno the size of your buttcheeks, but 5 ml per shot is normal, right?.

Beside that Primo is only 100 mg/ml you can switch to dihydroboldenone or just Boldenone with a double dosis and much cheaper.