Ostarine

[RonnyT Senior Member Find all posts View Profile Close RonnyT]

I will receive ostarine and I've never used it. Anyone here that has any real life expirience with it. I'll receive the tablets not the S4 form. I plan to test it on one of my friends.

[siberiantiger Senior Member Find all posts View Profile Close siberiantiger]

http://en.wikipedia.org/wiki/Ostarine

[siberiantiger Senior Member Find all posts View Profile Close siberiantiger]

RISK FACTORS ostarine

Table of Contents

In addition, in our Phase II clinical trial for OstarineTM for the treatment of cancer cachexia (cancer induced muscle loss), we observed mild elevations of hepatic enzymes in a few patients, and in our preclinical studies for OstarineTM, only at the highest doses, we observed expected selective effects on the reproductive and other target organs in the male population consistent with the stimulating and inhibiting effects on the androgen receptor which is located in these organs.
If the incidence of the events described above increases in number or severity, if a regulatory authority believes that these or other events constitute an adverse effect caused by the drug, or if other effects are identified during clinical trials that we are currently conducting, during clinical trials that we or our collaborators may conduct in the future or after any of our product candidates are approved and marketed:
? we or our collaborators may be required to conduct additional preclinical or clinical trials, make changes in labeling of any such approved products, reformulate any such products, or implement changes to or obtain new approvals of our contractors? manufacturing facilities;

? regulatory authorities may be unwilling to approve our product candidates or may withdraw approval of our products;

? we may experience a significant drop in the sales of the affected products;

? our reputation in the marketplace may suffer; and

? we may become the target of lawsuits, including class action suits.
Any of these events could prevent approval or harm sales of the affected product candidates or products, or could substantially increase the costs and expenses of commercializing and marketing any such products.

[siberiantiger Senior Member Find all posts View Profile Close siberiantiger]

OSTARINE_Selective androgen receptor modulator

Selective androgen receptor modulators or SARMs are a novel class of androgen receptor ligands. (The name follows the terminology currently used for similar molecules targeting the estrogen receptor, "selective estrogen receptor modulators," such as Tamoxifen.) They are intended to have the same kind of effects as androgenic drugs like anabolic steroids but be much more selective in their action,[1] allowing them to be used for many more clinical indications than the relatively limited legitimate uses that anabolic steroids are currently approved for.
Contents
[hide]

1 Comparison to testosterone
1.1 Selectivity in men
1.2 Selectivity in women
2 Examples
2.1 In clinical testing
2.2 Pre-clinical
2.3 Examples no longer being developed
3 See also
4 References

[edit] Comparison to testosterone

Currently used androgens for male hormone replacement therapy are typically injectable or skin delivery formulations of testosterone or testosterone esters. Injectable forms of testosterone esters (such as testosterone enanthate, propionate, or cypionate) produce undesirable fluctuations in testosterone blood levels, with overly high levels shortly after injection and overly low afterwards. Skin patches do provide a better blood level profile of testosterone, but skin irritation and daily application still limit their usefulness. Oral androgens are not currently used due to concerns about liver toxicity.

SARMs provide the opportunity to design molecules that can be delivered orally, but that selectively target the androgen receptors in different tissues differently. The goal of research in this area is to allow a customized response: tissues that are the target of the therapy will respond as they would to testosterone; other tissues where undesirable side effects are produced will not.

None of the SARMs yet developed are truly selective for anabolic effects in muscle or bone tissues without producing any androgenic effects in tissues such as the prostate gland, however several non-steroidal androgens show a ratio of anabolic to androgenic effects of greater than 3:1 and up to as much as 10:1, compared to testosterone which has a ratio of 1:1.[2][3][4]

This suggests that while SARMs are likely to show some virilizing effects when used at high doses (e.g., use by bodybuilders), at lower therapeutic doses they may well be effectively selective for anabolic effects, which will be important if SARMs are to have clinical application in the treatment of osteoporosis in women. One substantial advantage of even the first-generation SARMs developed to date is that they are all orally active without causing liver damage, whereas most anabolic steroids are not active orally and must be injected, and those anabolic steroids which are orally active tend to cause dose-dependent liver damage which can become life-threatening with excessive use. Research is continuing into more potent and selective SARMs, as well as optimising characteristics such as oral bioavailability and increased half-life in vivo, and seeing as the first tissue-selective SARMs were only demonstrated in 2003, the compounds tested so far represent only the first generation of SARMs and future development may produce more selective agents compared to those available at present.[5][6][7]
[edit] Selectivity in men

For example, if the target is bone growth in elderly men with osteopenia or osteoporosis, but with no overt signs of hypogonadism, a SARM targeting bone and muscle tissue, but with lesser activity on the prostate or testes would be more desirable.[8]
[edit] Selectivity in women

A SARM for women would ideally stimulate bone retention, or libido and other sexual function that androgens can influence, without negative side effects such as development of male gender characteristics (virilization), increased LDL/HDL ratios, liver dysfunction, and so forth.[9]
[edit] Examples
[edit] In clinical testing

Ostarine(MK-2866, GTx-024) - affects both muscle and bone, intended mainly for osteoporosis but also general treatment for andropause and reversing muscle sarcopenia in the elderly and for cachexia in cancer patients.[10]
BMS-564,929 - mainly affects muscle growth, intended as general treatment for symptoms of andropause
LGD-4033 - pharmacological profile similar to that of Ostarine

[hackleech Senior Member Find all posts View Profile Close hackleech]

s4 is not a a liquid form of ostarine thats a scam going around s4 is a whole different sarm
on s4 some people experianced lights a bit more yellow and eyes took longer to adjust during the night tho this is mostly at higher doses also some people at higher doses thought they might have lost a bit of sex drive
on ostarine there are no known side effects yet also ostarine is newer and stronger per mg about 2-3 times as strong so some people go around selling s4 claiming it's simply a different version of ostarine yet it is not also the only legit ostarine i know of is in liquid form never seen a legit tablet tho it's not impossible that exists

[iamready Senior Member Find all posts View Profile Close iamready]

My friend is on it right now. He is in pct as well after a 12 week test dbol var cycle. Ill ask him what he thinks

[RonnyT Senior Member Find all posts View Profile Close RonnyT]

the only legit ostarine i know of is in liquid form never seen a legit tablet tho it's not impossible that exists ... the companies release
http://evaluatepharma.com/Universal/...tory&id=249086
About Ostarine(TM)

Ostarine(TM) is an oral selective androgen receptor modulator that GTx is developing for the prevention and treatment of muscle wasting in patients with non-small cell lung cancer. GTx recently reached agreement with the United States Food and Drug Administration on the Ostarine Phase III clinical development plan

I spoke to the chemist of an UG lab that has very good contacts in China, I have a sample to try, when its bunk we'll soon find out..

[RonnyT Senior Member Find all posts View Profile Close RonnyT]

the pics

I'll keep you guys informed..

[siberiantiger Senior Member Find all posts View Profile Close siberiantiger]

Ostarine 100 tabs (5mg/tab)
Manufacturer: Generic Supplements, Europe/99$http://www.rxprohub.com/Ostarine.html In clinical testing:

Ostarine(MK-2866, GTx-024) - affects both muscle and bone, intended mainly for osteoporosis but also general treatment for andropause and reversing muscle sarcopenia in the elderly and for cachexia in cancer patients.[10]
BMS-564,929 - mainly affects muscle growth, intended as general treatment for symptoms of andropause
LGD-4033 - pharmacological profile similar to that of Ostarine

[edit] Pre-clinical

AC-262,356[11]

JNJ-28330835.[12][13]

LGD-2226 - affects both muscle and bone

LGD-3303[14]

S-40503 - selective for bone tissue, particularly low virilization, intended for osteoporosis and may be suitable for use in women

S-23 - under development as a male hormonal contraceptive[15]

[edit] Examples no longer being developed

Andarine ("S-4")[16] - partial agonist, intended mainly for treatment of benign prostatic hypertrophy