Tweet
Nutrient Cocktail Maintains Youth
Declining physical movement, known as bradykinesis, is considered a reliable biomarker of aging and risk of death. David Rollo, from McMaster University in Ontario, Canada, and colleagues formulated a dietary supplement consisting of ingredients such as vitamins B1, C, D, E, aspirin, beta-carotene, folic acid, garlic, ginger root, ginkgo biloba, ginseng, green-tea extract, magnesium, melatonin, potassium, cod liver oil and flaxseed oil. Multiple ingredients were combined based on their ability to offset five mechanisms involved in aging.
Feeding the formula to old mice by administering bagel bits soaked in the supplement, the team found that the formula maintained youthful locomotor activity into old age, whereas old mice that were not given the supplement showed a 50 percent loss in daily movement. In the latter group the researchers also observed a similar dramatic loss in activity of the mitochondria, the cellular furnaces that make energy, and declines in brain-signaling chemicals relevant to locomotion.
The researchers had this comment: ?Results provide proof of principle that complex dietary cocktails can powerfully ameliorate biomarkers of aging and modulate mechanisms considered ultimate goals for aging interventions.?
Aksenov, V., et al. (2010). Dietary amelioration of locomotor, neurotransmitter and mitochondrial aging. Exp Biol Med. 235:66-76.
?Dr. Bob Goldman
Declining physical movement, known as bradykinesis, is considered a reliable biomarker of aging and risk of death. David Rollo, from McMaster University in Ontario, Canada, and colleagues formulated a dietary supplement consisting of ingredients such as vitamins B1, C, D, E, aspirin, beta-carotene, folic acid, garlic, ginger root, ginkgo biloba, ginseng, green-tea extract, magnesium, melatonin, potassium, cod liver oil and flaxseed oil. Multiple ingredients were combined based on their ability to offset five mechanisms involved in aging.
Feeding the formula to old mice by administering bagel bits soaked in the supplement, the team found that the formula maintained youthful locomotor activity into old age, whereas old mice that were not given the supplement showed a 50 percent loss in daily movement. In the latter group the researchers also observed a similar dramatic loss in activity of the mitochondria, the cellular furnaces that make energy, and declines in brain-signaling chemicals relevant to locomotion.
The researchers had this comment: ?Results provide proof of principle that complex dietary cocktails can powerfully ameliorate biomarkers of aging and modulate mechanisms considered ultimate goals for aging interventions.?
Aksenov, V., et al. (2010). Dietary amelioration of locomotor, neurotransmitter and mitochondrial aging. Exp Biol Med. 235:66-76.
?Dr. Bob Goldman
Comment