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QuickBooks Error 6123 typically appears when trying to open a company file or restore a backup, often due to network issues, damaged files, or conflicts with security software. To resolve this error, first ensure that QuickBooks is updated to the latest version. You can then run the QuickBooks File Doctor tool to diagnose and fix the issue. Check your network connection to ensure it is stable, and if restoring a backup, try saving it locally before restoring. In some cases, renaming the .ND and .TLG files related to the company file can help reset the connection and clear the error.