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Epidermal growth factor receptor (EGFR), also known as ErbB-1, belongs to ErbB family of receptors. EGFR consists of 4 major parts, an extracellular domain, a hydrophobic transmembrane domain, an intracellular catalytic tyrosine kinase domain and several intracellular tyrosine residues. For more information: anti-EGFR CAR-T in vivo assay