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Eukaryotic chromosomes are formed by a series of folding events in nucleosome structures generated by DNA molecules wrapping histone proteins. There are some regions of chromatin that are loosely reformed, called open chromatin or open chromatin regions, where both DNA replication and gene transcription occur. Therefore, obtaining the information will help us understand the regulation of gene expression by open regions, as well as better understanding of biological regulation. Check more details: single-cell atac-seq san fransisco