Announcement

Collapse
No announcement yet.

Aromasin (exemestane)

Collapse
X
 
  • Filter
  • Time
  • Show
Clear All
new posts

  • Aromasin (exemestane)

    Exemestane is a steroidal suicide aromatase inhibitor. It isvery similar in structure and action to formestane, although it is significantly more potent in comparison. As a class of drugs, aromatase inhibitors offer an anti estrogenic effect by blocking the enzyme responsible for synthesizing estrogens. Exemestane is approved by the FDA for the treatment of breast cancer in women, specifically in post menopausal patients whose cancer has progressed following therapy with tamoxifen (nolvadex). Male bodybuilders and athletes often use the drug for non approved purposes, namely to counter the estrogenic side effects associated with the use of aromatizable anabolic/androgenic steroids. This may include gynecomastia, fat buildup, and water retention. Exemestane is one of the most potent aromatase inhibitors presently available. The most commonly cited date reports a lowering of estrogen around 85% on average in clinical studies with women. Exemestane was developed by Pharmacia & Upjohn, which gained FDA approval for sale of the drug in late 1999. They introduced it under the Aromasin brand name in early 2000. Although the drug proved to be effective in doses as low as 2.5mg per day in some patients, the company developed it in a standard and near universally effective dosage of 25mg per tablet. The company has since introduced the drug to many other nations under the same trade name of Aromasin.

    Aromasin, as it is most commonly called, is a very potent AI which works by blocking the aromatase enzyme in the body. This drug was originally developed to help fight breast cancer in women by reducing estrogen which some believe to aid in cancer cell growth. While not quite as strong as Letrozole, aromasin is considerably stronger than Anastrozole. Studies done with this substance typically show around an 85% reduction in estrogen levels in the body. This can be very useful to bodybuilders who are using aromatizing compounds such as testosterone. Typically, one will begin the use of aromasin the same day they begin their cycle. It is also important to note that Aromasin has shown to be very effective at increasing testosterone and IGF levels in the body. Because of this, this drug is also very useful during PCT regime when one is trying to restore natural testosterone levels in order to avoid a post cycle "crash". It is important to keep doses of aromasin reasonable, as too much estrogen suppression can result in hindered muscle gains and loss of sex drive. One 25mg tablet a day should be sufficient for effectively keeping estrogen related sides out of the picture, or for effectively raising natural testosterone levels during PCT.

    Exemestane reaches peak plasma concentrations within 2 hours following the oral administration of a 25 mg dose. The active life of the drug is between 24 and 30 hours. This is significant since it is quite shorter than for the non-steroidal inhibitors. A single oral dose of 25 milligrams of exemestane causes a relatively long-lasting reduction in plasma and urinary estrogen levels, with maximal suppression occurring approximately 2 to 3 days after dosing and persists for about 4 to 5 days.It has been shown that 25 milligrams of exemestane is basically just as effective as 50 milligrams at suppressing estrogen, raising testosterone levels, and levels of IGF. It is therefore unnecessary to go higher in doses than 25 milligrams per day. Due to the active life of the compound exemestane should be administered roughly once every twenty-four hours. Users often start the drug on the first or second week of steroid use and continue to take it throughout the cycle and for a few weeks afterwards in order to prevent any type of estrogen rebound.

    ***Info from www.DrugsProfiles.com

  • #2
    nice post, im using this in my next cycle so was nice to read some more.

    Comment


    • #3
      Originally posted by dr.Stack View Post
      nice post, im using this in my next cycle so was nice to read some more.
      Yeah, I use Aromasin over Arimidex...it just seems to work better for me

      Comment


      • #4
        i have yet to use Aromasin... Still have dex on hand.

        Comment


        • #5
          and theres not the rebound effect like there is with letro...

          Comment


          • #6
            true!

            solid AI, comes highly recommended.

            Comment


            • #7
              Nice post thank you. I'm switching out adex for asin. Yet I'm very curious on average how much of a increase would asin give TT and igf? Is it < less than 3% ? Adex increased my cholesterol by 24%. :-(

              Comment


              • #8
                anti-E

                ANTI-ESTROGENS

                Its said that letrozole is the strongest and doesn?t negatively affect cholesterol, this is not true. Letrozole is NOT the strongest and it DOES negative affect cholesterol/lipid profile in a bad way.

                Aromasin? (exemestane) is the best, this is why, both Arimidex?/LiquidDex (anastrozole) and Femara? (letrozole) hurt your cholesterol. the way these two anti-estrogens work is they inhibit the aromatase enzyme. By inhibiting the enzyme which converts testosterone to estrogen, you reduce or even come close to eliminating estrogen production. we need some estrogen to be healthy. The major drawback to this is without estrogen, your lipid profile gets fucked.

                Exemestane works differently. it does not stop the body from producing estrogen, rather, it makes it so the estrogen is unable to bind to receptors by deactivating the binding enzyme. If the estrogen cannot bind, you simply will not get bloated or get gynocomastia. The estrogen is crippled due to Exemestane. However, since the estrogen is still floating around, it will not negatively affect your lipid/cholesterol profile.

                Anastrozole doesn?t cause a rebound effect, and neither does Exemestane, but Letrozole does, this means after you stop the Letrozole, your estrogen rebounds and goes pretty high for a while, eventually it normalizes. you can avoid this by tapering your letro dose down before stopping it, but that is a pain in the ass, higher than normal can mess many things up post cycle when you stop. since the hpta has a feedback loop is primarily controlled by estrogen, high estrogen will tell your hpta to produce less testosterone, because it thinks the high estrogen is caused by too much testosterone. this is fact. now post cycle, dont we want to raise our test levels, not lower them? Of course! So rebounds are bad, if you use letrozole taper the dose off to zero over a couple weeks.

                Nolvadex(tamoxifen) is a SERM(Selective Estrogen Receptor Modulator), this means on certain tissue it can act antagonisticaly or agonistically. In the case of lipid profiles, it acts agonistically, so, running tamoxifen with your anti-estrogens will IMPROVE your cholesterol profile even if not on cycle or using any gear or other anti-estrogens. Its just plain good for cholesterol.

                One thing to keep in mind though when running tamoxifen with letro. letro reduces blood levels of tamoxifen by over 50%. a study showed 2.5mg letro ed made nolva levels drop to 40% of what they were before adding letro. this does not mean you cant use tamoxifen with letro, it just means you need to use more, about double. 20mg of nolva will act like 8mg if running letro. so make sure you are aware of this because you will need to buy more nolva to compensate. this does not happen when mixing tamoxifen with anastrozole or exemestane, it only hppens with letrozole.

                Also, many people and myself experience a reduction of libido on letrozole, this doesn?t happen with anastrozole or exmestane as far as I know, and in my own experience, and I?ve run all three quite a bit.

                The best combo IS exemestane and tamoxifen together. your cholesterol will be as good as can be considering your on a cycle of steroids, the dose of aromasin will vary depending on the users needs and how much aromatizing gear is being taken, usually 10-25mg ed works well, run 10mg ed nolvadex to improve your cholesterol. Second best combo I feel is anastrozole and tamoxifen. Anastrozole dose ranges from usually .15mg ed to 1mg ed. run 10mg nolva ed to improve cholesterol. Third best is letrozole and nolvadex. letrozole doses usually range from 1 ? 2,5mg e.d, run 20mg ed nolvadex to improve cholesterol with letrozole.
                You do not need to run nolvadex with any of these three, I do recommend it though as it will improve cholesterol compared to using the anti e's alone without nolva.

                So in order of strength, on a dose per dose basis(not mg per mg) aromasin is defenitly the strongest, a close next is letrozole, and then anastrozole.

                I?ve been running aromasin now for about 4 months, I wont switch back to ldex or letro, it works much better and its much healthier for cholesterol profiles.

                I think we all need to stop only worrying about side effects that we can see visually. cholesterol KILLS many people around the world everyday(well not directly kills but leads to it). steroids are hurting us badly in this sense. steroids do mess our cholesterol up pretty badly, and we will pay for it later in life. now not many of us are going to stop using gear because of that, but we should at least take the proper other drugs to help minimize.

                Aromasin is only a little bit more expensive than ldex or letro, and its actually about the same price as many places sell ldex or letro for. but its more powerful and healthier. people spend money all the time on steroids which don?t have as many side effects as some of the harsher, cheaper steroids. A few extra bucks for the proper anti-estrogens is def money well spent.

                Proviron has four distinct uses in the world of bodybuilding. The first being the result of its structure. It is 5-alpha reduced and not capable of forming estrogen, yet it nonetheless has a much higher affinity for the aromatase enzyme (which converts testosterone to estrogen) than testosterone does. That means in administering it with testosterone or another aromatizable compound, it prevents estrogen build-up because it binds to the aromatase enzyme very strongly, thereby preventing these steroids from interacting with it and forming estrogen. So Mesterolone use has the extreme benefit of reducing estrogenic side-effects and water retention noted with other steroids, and as such still help to provide mostly lean gains. Its also been suggested that it may actually downgrade the actual estrogen receptor making it doubly effective at reducing circulating estrogen levels.

                The second use is in enhancing the potency of testosterone. Testosterone in the body at normal physiological levels is mostly inactive. As much as 97 or 98 percent of testosterone in that amount is bound to sex hormone binding globulin (SHBG) and albumin, two proteins. In such a form testosterone is mostly inactive. But as with the aromatase enzyme, DHT has a higher affinity for these proteins than testosterone does, so when administered simultaneously the mesterolone will attach to the SHBG and albumin, leaving larger amounts of free testosterone to mediate anabolic activities such as protein synthesis. Another way in which it helps to increase gains. Its also another part of the equation that makes it ineffective on its own, as binding to these proteins too, would render it a non-issue at the androgen receptor.

                Thirdly, mesterolone is added in pre-contest phases to increase a distinct hardness and muscle density. Probably due to its reduction in circulating estrogen, perhaps due to the downregulating of the estrogen receptor in muscle tissue, it decreases the total water build-up of the body giving its user a much leaner look, and a visual effect of possessing "harder" muscles with more cuts and striations. Proviron is often used as a last-minute secret by a lot of bodybuilders and both actors and models have used it time and again to deliver top shape day in day out, when needed. Like the other methylated DHT compound, drostanolone, mesterolone is particularly potent in achieving this feat.

                Lastly Proviron is used during a cycle of certain hormones such as nandrolone, with a distinct lack of androgenic nature, or perhaps 5-alpha reduced hormones that don't have the same affinities as DHT does. Such compounds, thinking of trenbolone, nandrolone and such in particular, have been known to decrease libido. Limiting the athlete to perform sexually being the logical result. DHT plays a key role in this process and is therefore administered in conjunction with such steroids to ease or relieve this annoying side-effect. Proviron is also commonly prescribed by doctors to people with low levels of testosterone, or patients with chronic impotence. Its not perceived as a powerful anabolic, but it gets the job done equally well if not better than other anabolic steroids making it a favourite in medical practices due to its lower chance of abuse.

                Comment


                • #9
                  nice post!

                  Comment


                  • #10
                    picture

                    The picture that belongs to the article. You'll notice a box of Avodart on the pic:

                    Dutasteride is the generic name for a new dual 5 alpha-reductase inhibitor made by GlaxoSmithKline. The drug is set to be marketed under the name Avodart? in the US and Avolve? in Europe in December 2002.

                    The FDA has approved Dutasteride for treating BPH (Benign Prostate Hyperplasia), the same condition that Proscar?, by made Merck, is used for. Dutasteride like Finasteride, the active ingredient in Proscar and Propecia, also has the added benefit of being able to be used to treat genetic hair loss in men also known as MPB or Androgenic Alopecia.

                    The difference between Dutasteride and Finasteride is that Dutasteride inhibits the activities of both the type 1 and type 2 5AR enzymes unlike Finasteride which only inhibits type 2. These enzymes are responsible for the conversion of testosterone into DHT (dihydrotestosterone). DHT is the primary cause of prostate growth and hair loss and Dutasteride decreases levels of DHT by 90 percent after only two weeks making it a much more powerful weapon against hair loss and BPH.

                    Dutasteride.org is a site dedicated to providing you with up-to date information about the use of Dutasteride for BPH and Androgenic Alopecia. It's important to note that the FDA has not approved Dutasteride for the treatment of hair loss but Glaxo has completed Phase 2 trials for its use in treating hair loss.
                    Attached Files

                    Comment


                    • #11
                      Hey Ronny
                      Does adex help you lose fat easier if used two weeks before a contest.
                      Thanks
                      Fng

                      Comment


                      • #12
                        Yep, all anti-e do ofcourse but most people prefer clen and ephedrine or the combo, more hardcore is DNP etc

                        Comment


                        • #13
                          Aromasin ?
                          Your medicine is called Aromasin. Aromasin belongs to a group of drugs known as aromatase inhibitors. These resources inhibit the enzyme aromatase, which is required in the production of female sex hormones, estrogens. especially in women after menopause. Decrease of estrogen in the body's way to a hormone-sensitive breast cancer treatment.

                          Aromasin may be used to complement the treatment of estrogen-sensitive early breast cancer in postmenopausal women. However, they should first 2 to 3 years with tamoxifen to be treated.

                          Aromasin can also be used for the treatment of extensive breast cancer in women after the menopause, when another hormonal drug has been effective enough.

                          Comment


                          • #14
                            Like most AAS - anti-E etc ,its of label use. It was meant for a different medical reason, but bodybuilders use them for a different reason

                            Originally posted by heavilyjuiced View Post
                            Aromasin ?
                            Your medicine is called Aromasin. Aromasin belongs to a group of drugs known as aromatase inhibitors. These resources inhibit the enzyme aromatase, which is required in the production of female sex hormones, estrogens. especially in women after menopause. Decrease of estrogen in the body's way to a hormone-sensitive breast cancer treatment.

                            Aromasin may be used to complement the treatment of estrogen-sensitive early breast cancer in postmenopausal women. However, they should first 2 to 3 years with tamoxifen to be treated.

                            Aromasin can also be used for the treatment of extensive breast cancer in women after the menopause, when another hormonal drug has been effective enough.

                            Comment


                            • #15
                              ok thnx RonnyT

                              Comment

                              Working...
                              X