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  • Pramipexole

    Pramipexole
    Unlike bromo and Dostinex, Pramipexole is a NON ergot dopamine agonist with high in vitro specificity at the D2 subfamily of dopamine receptors. Pramipexole is a complete agonist and clearly displays a higher affinity to the D3 receptors than to D2 or D4 receptors. While pramipexole displays high affinity for the D2 receptors, it still has low affinity for a2-adrenergic receptors and an untraceable affinity for other dopaminergic, histaminergic, adrenergic, and other receptors. This stuff is POTENT, even though its biggest positive effects on GH are within the first 3 hours after dosing, it still significantly lowers prolactin and for some reason it seems to also have the biggest positive effect on increasing testosterone over all other prolactin blockers. It makes me laugh because the most common feedback you hear about it from someone experiencing it for the first time is the stuffy nose, which is from the increased dopamine which means its working its designated effects.

    By Needtogetaas

  • #2
    Schilling JC, Adamus WS, Palluk R.

    Human Pharmacology Centre, Boehringer Ingelheim KG, Germany.

    The effects and tolerability of pramipexole, a new dopamine D2-receptor agonist, on prolactin, human growth hormone, thyrotropin, cortisol, and corticotropin levels were investigated in a randomized, double-blind, crossover study in 12 healthy volunteers. Single oral doses of 0.1, 0.2, and 0.3 mg pramipexole and placebo were studied over a period of 24 hours. Pramipexole decreased serum prolactin levels in a dose-dependent manner, with a maximum effect after 2 to 4 hours. Serum levels of human growth hormone were dose-dependently increased; however, this effect was only significant 2 hours after drug administration. Furthermore, a slight increase in serum cortisol levels and a slight decrease in serum thyrotropin levels was observed. Our findings show for the first time pharmacodynamic effects of pramipexole after single oral doses in healthy volunteers. The compound was well tolerated and showed an endocrine profile similar to other dopamine D2-agonists.

    PMID: 1350237 [PubMed - indexed for MEDLINE]

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