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  • Arimidex (anastrozole)

    Anastrozole is an anti estrogenic drug developed for the treatment of advanced breast cancer in women. Specifically, this agent is the first in a newer class of third generation selective oral aromatase inhibitors. It acts by blocking the enzyme aromatase, subsequently blocking the production of estrogen in the body. Since many forms of breast cancer cells are stimulated by estrogen, reducing levels of this hormone in the body may retard the progression of the disease. This is also the fundamental use of tamoxifen citrate (Nolvadex), except nolvadex blocks the action of estrogen at the receptor, not its actual endogenous production. The effects of anastrozole can be very substantial, with a daily dosage of 1mg capable of production estrogen suppression greater than 80% in treated patients. With the powerful effect this drug has on hormone levels, it is usually only prescribed to post menopausal women. Anastrozole was developed by Zeneca Pharmaceuticals, and approved for use in the United States at the end of 1995. The drug was developed as a new adjunct treatment for operable breast cancer in postmenopausal female patients, an area of medicine that had a long history of nolvadex use. Substantial date was needed to shit prescribing trends away from such an established medication treatment.

    Most commonly called Arimidex, this substance is a true aromatase inhibitor which works by blocking the aromatase enzyme in the body, thus limiting the amount of estrogen buildup that takes place. This compound has obvious benefits to bodybuilders who use aromatizing steroids such as testosterone. These individuals might face estrogen related side effects such as water bloat and "gyno", but by taking Arimidex while on cycle, the chance of any of these sides are greatly reduced. In studies that have been done, Arimidex has been shown to reduce estrogen in the body by roughly 50%. This is a good balance for bodybuilders , because some estrogen is needed in order for the full anabolic benefits of the steroids being taken to be achieved. These results are typically the same with a dosage of .5 mg a day as they are with a dosage of 1 mg a day, meaning that in most cases, a half tablet a day will be sufficient for estrogen control throughout cycle. Typically, bodybuilders using Arimidex will begin taking it the day they start their cycle, and will run it throughout the duration of steroid administration. It is also important to point out Arimidex?s ability to increase testosterone in the body. Some studies have shown that natural testosterone levels have increases as much as 60% after the use of this substance for 7 days. Because of this, bodybuilders find this drug extremely effective during PCT where as they are trying to elevate natural levels as much as possible in order to avoid a post cycle "crash".

    When used to mitigate the estrogenic side effects of anabolic/androgenic steroid use, male athletes and bodybuilders will commonly take a dose of .5mg to 1mg of anastrozole per day. In some instances a half of a tablet taken every other day is sufficient to mitigate the buildup of estrogen. When used with readily aromatizing androgens such as methandrostenolone or testosterone, gynecomastia and water retention are often effectively blocked. Additionally, the use of anastrozole may decrease fat mass, which can also be tied to estrogen levels. The result can be a harder and much more defined look to the muscles and physique, which makes this agent of interest for dieting and cutting purposes as well.
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  • #2
    Very good post. I've been on Adex and I take .25 every other day. This dose works best for me. The side affects are small and at this dose I am able to keep my estrogen levels down yet not totally wiped out.

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    • #3
      it also helps get rid of water so when you are doing products like dbol or anadrol you can gain a sufficent amount of lean muscle mass and maintain it!!!

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      • #4
        That article is so true. If I were to do something I would include arimdex. During blood test of prescribed people, using arimidex 1mg per day completely stops converting to estrogen. But at a doctor stand point that is not good. We need some estrogen, so a doctor will tell you to take .05mg either every day or every other day. Keep track of blood work. After test obtain your own copies of your blood work. Always check with your doctor.

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        • #5
          Great post! It answered a lot of questions I had. I'm preparing for my 1st cycle so i'm not sure if i'm prone to gyno or not so I ordered some of this to take during cycle. Whenever I ask a question about adex members want to bash me & tell me I shouldn't do a cycle yet. Fact is,i'm the 1 making that decision so why not help me out as much as possible instead of bashing me. I appreciate your help here as well as other boards!!!!

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          • #6
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            • #7
              Anyone ever have Adex cause gyno to flare up / get worse? The first time I took it, it almost totally wiped out my gyno. Then I took it again about a year later and it made my gyno way worse. I did not really notice at first so i figured if i just kept taking it, it would eventually work out. Not the case. I now have it under control but I am going to avoid that stuff from now on. My current workout partner has a similar story.

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              • #8
                Originally posted by getbigger67 View Post
                Anyone ever have Adex cause gyno to flare up / get worse? The first time I took it, it almost totally wiped out my gyno. Then I took it again about a year later and it made my gyno way worse. I did not really notice at first so i figured if i just kept taking it, it would eventually work out. Not the case. I now have it under control but I am going to avoid that stuff from now on. My current workout partner has a similar story.
                Anyone one else have this experience taking Adex?

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                • #9
                  yOU SURE IT WAS REAL? iT WILL SHUT DOWN YOUR ESTROGEN. IF USED TO MUCH.. NO WAY.

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                  • #10
                    I thought the same thing Safelife so I kept using / increasing dose thinking "maybe it will kick in in a few more days." Seemed to only get worse so i stopped using it. I got it from Chem_one_research. Not sure if anyone is familiar but back then word on the internet was they were legit. I thought that maybe i got a bad batch so i bought it again from a different supplier and the same exact thing happened.

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